Results 171 to 180 of about 169,468 (266)

Artificial Host‐Guest Recognition Directs Glycometabolically Engineered Macrophages to Tumors

Advanced Science, EarlyView.
Glycoengineered supramolecular macrophages (GSAR‐M) are developed using glycometabolic labeling for bioorthogonal host‐guest tumor targeting. This engineering approach unexpectedly enhances macrophage migration, phagocytosis, and pseudopodia formation. Consequently, GSAR‐M demonstrate robust tumor‐targeting specificity, effectively arrest tumor growth,
Zhiqing Yang, Qian Cheng, Ziyi Wang, Jianwen Wei, Qun Guan, Huazhong Yu, Qingwen Zhang, Caixia Yin, Ruibing Wang   +8 more
wiley   +1 more source

Heat-not-burn tobacco induces protein post-translational modifications and apoptosis in bronchial cells: possible role in rheumatoid arthritis. [PDF]

RMD Open
Ciancarella C, Ucci FM, Manganelli V, Garofalo T, Fasciolo E, Priori R, Ceccarelli F, Sergi M, Montesano C, Bartolini F, Sili Scavalli A, Conti F, Sorice M, Alessandri C.   +13 more
europepmc   +1 more source

TET1 Inhibition Promotes Therapeutic Sensitivity in TP53‐Mutant GBM by Influencing Genome Fragility and Altering TAMs Biology

Advanced Science, EarlyView.
In TP53mut GBM cells, reduced P53 function is associated with increased TET1 expression. Genetic or pharmacological inhibition of TET1 correlates with genome fragility, including DNA damage, cellular senescence, telomere shortening, and reactive oxygen species accumulation, which may contribute to increased efficacy of antitumor therapy.
Zhuonan Pu, Jinqiu Liu, Yuxuan Deng, Shuyu Hao, Xiaoli Zhang, Mingxu Yang, Chao Guo, Chao Du, Yingdan Chen, Tai Sun, Nan Ji, Zhengping Zhuang, Jie Feng   +12 more
wiley   +1 more source

Optimized ultrasound extraction and cytotoxic activity against HeLa cervical cancer cells of total flavonoids of <i>Physochlaina physaloides</i> (L.) G. Don. [PDF]

Front Pharmacol
Sun ZY, Xu J, Wei W.
europepmc   +1 more source

Microenvironment‐Responsive Nanomedicine Enables Vertical Modulation of Mitochondrial Pathological Networks in Myocardial Ischemia–Reperfusion Injury

Advanced Science, EarlyView.
A mitochondria‐targeted, microenvironment‐responsive nanoplatform enables pH/ROS‐triggered co‐delivery of berberine and isoliensinine to orchestrate ROS scavenging, inflammation suppression, and apoptosis inhibition. This vertical modulation of mitochondrial pathological networks preserves mitochondrial function and effectively mitigates myocardial ...
Jue Wang, Jia Zhou, Wenqin Yuan, Tianjiao Zhao, Yunying Huang, Yingci Xia, Yuting Lin, Fei Li, Qiong Huang, Chong Liu, Kelong Ai, Qun Qin   +11 more
wiley   +1 more source

Cypripedin Induces Apoptosis and Synergizes with Bortezomib via ER Stress Mediated Ubiquitination of GRP78 in T-Cell Acute Lymphoblastic Leukemia. [PDF]

Molecules
Ei ZZ, Nutho B, Sritularak B, Chanvorachote P, Chunhacha P.   +4 more
europepmc   +1 more source

CALB2 is a Mechanoresistance Gene in Metastatic Prostate Cancer

Advanced Science, EarlyView.
Prostate cancer cell lines of differing origins were cultured over many passages while being subjected to semi‐lethal levels of fluid shear stress, representing the harsh mechanical environment these cells are subjected to in the circulation during the process of distant metastasis.
Abigail R. Fabiano, Allen C. Luo, Paul Taufalele, Jenna A. Dombroski, Ehsan Aalaei, Schyler J. Rowland, Melissa S. Cantú, Alexandria T. Carter, Samantha V. Knoblauch, Cynthia A. Reinhart‐King, Michael R. King   +10 more
wiley   +1 more source

Cytoprotective and Genoprotective Effects of Gelatin-Encapsulated Quercetin Against Oxidative Cell Damage. [PDF]

Molecules
Potapovich A, Kostyuk T, Shutava T, Kostyuk V.   +3 more
europepmc   +1 more source

High‐Throughput Mechanical Rupture of Nuclear Envelope and the Intracellular Dynamics of Massive Wound Repair

Advanced Science, EarlyView.
A microfluidic device with monolithically integrated nanostructures enables high‐throughput wounding of the cell membrane and nuclear envelope. The spatial distribution of charged multivesicular body protein 4B (CHMP4B) within the cell is mapped before and after wounding, showing involvement in repair of both the cell membrane and nuclear envelope ...
Apresio K. Fajrial, Leyla Akh, Stephanie E. Schneider, Wei Tan, Corey P. Neu, Xiaoyun Ding   +5 more
wiley   +1 more source

A Novel Dysferlin-Binding Kinase CK2α Promotes Plasma Membrane Repair in Dysferlinopathy. [PDF]

FASEB J
Nakamura N, Suzuki N, Kanno SI, Yamanaka R, Ono H, Izumi R, Muliang R, Borgo C, Ohno A, Harada R, Saito S, Funayama Y, Ikeda K, Mitsuzawa S, Watanabe Y, Shijo T, Akiyama T, Takahashi T, Kanzaki M, Osana S, Warita H, Aoki Y, Ebihara S, Salvi M, Nagatomi R, Yasui A, Miyake K, Aoki M.   +27 more
europepmc   +1 more source