Results 1 to 10 of about 483,797 (293)
ER-dependent membrane repair of mycobacteria-induced vacuole damage [PDF]
mBio, 2023 Several intracellular pathogens, such as Mycobacterium tuberculosis, damage endomembranes to access the cytosol and subvert innate immune responses. The host counteracts endomembrane damage by recruiting repair machineries that retain the pathogen inside
Aby Anand +13 more
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Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain
Cells, 2020 Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably
Coralie Croissant +4 more
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Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models [PDF]
BiomoleculesAlzheimer’s Disease (AD) is the most common neurodegenerative disease that involves neuronal cell death initiated by the breakdown of the plasma membrane.
Hannah R. Bulgart +2 more
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Cell Reports, 2020 Summary: Plasma membrane damage and cell death during processes such as necroptosis and apoptosis result from cues originating intracellularly. However, death caused by pore-forming agents, like bacterial toxins or complement, is due to direct external ...
Ning Wu +16 more
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Normal Cortical Myelination in Galectin-4-Deficient Mice
Cells, 2022 Myelin, critical for the correct function of the nervous system, is organized in different patterns that can include long non-myelinated axonal segments. How myelin patterning is regulated remains unexplained. The carbohydrate-binding protein galectin-4 (
María Elvira Brocca +8 more
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Is MG53 a potential therapeutic target for cancer?
Frontiers in Endocrinology, 2023 Cancer treatment still encounters challenges, such as side effects and drug resistance. The tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence, development, and drug resistance of tumors.
Yunyu Du +3 more
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Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin
Toxins, 2023 Clostridium perfringens iota-toxin is composed of two separate proteins: a binding protein (Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic protein and (Ia) possessing ADP-ribosyltransferase activity that induces ...
Masahiro Nagahama +3 more
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Impairment of Ceramide-Mediated Endothelial Instant Membrane Resealing During Diabetes Mellitus
Frontiers in Physiology, 2022 Recent studies have indicated that instant cell membrane resealing (ICMR) controls the activation of NOD-like receptor pyrin domain containing 3 (Nlrp3) inflammasomes in endothelial cells, thereby initiating and promoting vascular inflammation.
Yang Chen +6 more
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Open Biology, 2021 The membranes of endosomes, phagosomes and macropinosomes can become damaged by the physical properties of internalized cargo, by active pathogenic invasion or by cellular processes, including endocytic maturation.
Eleanor Childs +3 more
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Clinical and Translational Discovery, 2023 Background Annexin A2 contributes to several key cellular functions and processes, including membrane repair. Effective repair prevents cell death and degeneration, especially in skeletal or cardiac muscle, epithelia, and endothelial cells.
Victor G. Kayejo +3 more
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