Results 11 to 20 of about 747,654 (296)
Membrane Repair: Mechanisms and Pathophysiology
Physiological Reviews, 2015 Eukaryotic cells have been confronted throughout their evolution with potentially lethal plasma membrane injuries, including those caused by osmotic stress, by infection from bacterial toxins and parasites, and by mechanical and ischemic stress. The wounded cell can survive if a rapid repair response is mounted that restores boundary integrity. Calcium
Sandra T, Cooper, Paul L, McNeil
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Is MG53 a potential therapeutic target for cancer?
Frontiers in Endocrinology, 2023 Cancer treatment still encounters challenges, such as side effects and drug resistance. The tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence, development, and drug resistance of tumors.
Yunyu Du +3 more
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Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin
Toxins, 2023 Clostridium perfringens iota-toxin is composed of two separate proteins: a binding protein (Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic protein and (Ia) possessing ADP-ribosyltransferase activity that induces ...
Masahiro Nagahama +3 more
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Dysferlin and muscle membrane repair [PDF]
Current Opinion in Cell Biology, 2007 The ability to repair membrane damage is conserved across eukaryotic cells and is necessary for the cells to survive a variety of physiological and pathological membrane disruptions. Membrane repair is mediated by rapid Ca(2+)-triggered exocytosis of various intracellular vesicles, such as lysosomes and enlargeosomes, which lead to the formation of a ...
Renzhi, Han, Kevin P, Campbell
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Pharmaceutics, 2020 Electroporation—a transient electric-field-induced increase in cell membrane permeability—can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy.
Diana Navickaite +6 more
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How to alleviate cardiac injury from electric shocks at the cellular level
Frontiers in Cardiovascular Medicine, 2022 Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome.
Pamela W. Sowa +9 more
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Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
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Calcium signaling in membrane repair [PDF]
Seminars in Cell & Developmental Biology, 2015 Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM) disruptions occur. Models of PM repair mechanisms include the "lipid-patch", "endocytic removal", and "macro-vesicle shedding" models, all of which postulate a dependence on local increases in intracellular Ca(2+) at injury sites.
Xiping, Cheng +3 more
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Mycobacterium tuberculosis type VII secretion system effectors differentially impact the ESCRT endomembrane damage response [PDF]
, 2018 Mycobacterium tuberculosis causes tuberculosis, which kills more people than any other infection. M. tuberculosis grows in macrophages, cells that specialize in engulfing and degrading microorganisms.
Hanson, Phyllis I +7 more
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Eardrum regeneration: membrane repair [PDF]
Nature, 2017 Can tissue engineering provide a cheap and convenient alternative to surgery for eardrum repair?
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