Results 11 to 20 of about 470,592 (258)
Is MG53 a potential therapeutic target for cancer?
Frontiers in Endocrinology, 2023 Cancer treatment still encounters challenges, such as side effects and drug resistance. The tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence, development, and drug resistance of tumors.
Yunyu Du +3 more
doaj +1 more source
Cellular Uptake and Cytotoxicity of Clostridium perfringens Iota-Toxin
Toxins, 2023 Clostridium perfringens iota-toxin is composed of two separate proteins: a binding protein (Ib) that recognizes a host cell receptor and promotes the cellular uptake of a catalytic protein and (Ia) possessing ADP-ribosyltransferase activity that induces ...
Masahiro Nagahama +3 more
doaj +1 more source
Pharmaceutics, 2020 Electroporation—a transient electric-field-induced increase in cell membrane permeability—can be used to facilitate the delivery of anticancer drugs for antitumour electrochemotherapy.
Diana Navickaite +6 more
doaj +1 more source
Dysferlin and muscle membrane repair [PDF]
Current Opinion in Cell Biology, 2007 The ability to repair membrane damage is conserved across eukaryotic cells and is necessary for the cells to survive a variety of physiological and pathological membrane disruptions. Membrane repair is mediated by rapid Ca(2+)-triggered exocytosis of various intracellular vesicles, such as lysosomes and enlargeosomes, which lead to the formation of a ...
Renzhi, Han, Kevin P, Campbell
openaire +2 more sources
How to alleviate cardiac injury from electric shocks at the cellular level
Frontiers in Cardiovascular Medicine, 2022 Electric shocks, the only effective therapy for ventricular fibrillation, also electroporate cardiac cells and contribute to the high-mortality post-cardiac arrest syndrome.
Pamela W. Sowa +9 more
doaj +1 more source
Leveraging Plasma Membrane Repair Therapeutics for Treating Neurodegenerative Diseases
Cells, 2023 Plasma membrane repair is an essential cellular mechanism that reseals membrane disruptions after a variety of insults, and compromised repair capacity can contribute to the progression of many diseases.
Hannah R. Bulgart +2 more
doaj +1 more source
The septin cytoskeleton is required for plasma membrane repair [PDF]
EMBO ReportsM Isabella Prislusky +2 more
exaly +2 more sources
Calcium signaling in membrane repair [PDF]
Seminars in Cell & Developmental Biology, 2015 Resealing allows cells to mend damaged membranes rapidly when plasma membrane (PM) disruptions occur. Models of PM repair mechanisms include the "lipid-patch", "endocytic removal", and "macro-vesicle shedding" models, all of which postulate a dependence on local increases in intracellular Ca(2+) at injury sites.
Xiping, Cheng +3 more
openaire +2 more sources
Plasma membrane integrity in health and disease: significance and therapeutic potential
Cell Discovery, 2021 Maintenance of plasma membrane integrity is essential for normal cell viability and function. Thus, robust membrane repair mechanisms have evolved to counteract the eminent threat of a torn plasma membrane.
Catarina Dias, Jesper Nylandsted
doaj +1 more source
Frontiers in Physiology, 2023 Neuroscientists and Cell Biologists have known for many decades that eukaryotic cells, including neurons, are surrounded by a plasmalemma/axolemma consisting of a phospholipid bilayer that regulates trans-membrane diffusion of ions (including calcium ...
Marshal L. Mencel, George D. Bittner
doaj +1 more source