Results 1 to 10 of about 1,176 (169)

YTHDF2 mediates the protective effects of MG53 on myocardial infarction injury via recognizing the m6A modification of MG53 [PDF]

Journal of Cardiothoracic Surgery
Introduction High levels of MG53 may attenuate the damage from myocardial infarction (MI). Furthermore, N6-methyl-adenosine (m6A) methylation is a mode of RNA modification that influences mRNA functions.
Zhaojie Li, Kai Li, Jianqiang Zhao
doaj   +4 more sources

Is MG53 a potential therapeutic target for cancer? [PDF]

Frontiers in Endocrinology, 2023
Cancer treatment still encounters challenges, such as side effects and drug resistance. The tripartite-motif (TRIM) protein family is widely involved in regulation of the occurrence, development, and drug resistance of tumors.
Yunyu Du, Yunyu Du, Tieying Li, Muqing Yi   +3 more
doaj   +4 more sources

MG53, a Regenerative Myokine Linking Skeletal Muscle to Cardiac Repair [PDF]

Biomolecules
Mitsugumin 53 (MG53, also TRIM72) is a muscle-enriched tripartite motif protein with a well-established role in acute membrane repair and cytoprotection in striated muscle and other stressed tissues. MG53 is a core component of cellular repair machinery,
Yuchen Chen, Kyung Eun Lee, Jongsoo Kim, Jae-Kyun Ko, Ki Ho Park   +4 more
doaj   +3 more sources

MG53 protects against intestinal inflammation by inhibiting NLRP3 inflammasome activation [PDF]

Frontiers in Pharmacology
Background and ObjectivesInflammatory bowel disease (IBD) involves dysregulated immune responses and chronic intestinal inflammation. The nod-like receptor pyrin domain–containing 3 (NLRP3) inflammasome plays a critical role in IBD pathogenesis, but ...
Zhongguang Li, Zhongguang Li, Zachary D. Dawson, XiangGuang Li, Serenali Zhao, Mattew Bu, Fei Jiang, Fei Jiang, Yuchen Chen, Min Zhang, Xindi Zeng, Ki Ho Park, Ki Ho Park, Jing Lu, Jinshan He, KyungEun Lee, KyungEun Lee, Prosper N. Boyaka, Haichang Li, Haichang Li, Haichang Li, Jianjie Ma, Jianjie Ma   +22 more
doaj   +5 more sources

MG53 alleviates hypoxia/reoxygenation-induced cardiomyocyte injury by succinylation and ubiquitination modification

Clinical and Experimental Hypertension, 2023
Background Mitsugumin 53 (MG53) is a membrane repair factor that is associated with acute myocardial infarction. This study aimed to investigate the effects of MG53 on cardiomyocyte injury and the posttranslational modification of MG53.
Yan Wang, Hongying Zhou, Jin Wu, Shanshan Ye   +3 more
exaly   +2 more sources

Gait analysis for functional evaluation in a surgical hindlimb suspension model of muscle atrophy. [PDF]

J Physiol
Abstract figure legend Gait analysis reveals neuromuscular dysfunction following hindlimb suspension and partial recovery after reloading. Schematic overview of the experimental design and principal findings. Mice underwent 14 days of hindlimb suspension (HLS), resulting in muscle atrophy marked by reduced fiber size, satellite cell loss, and decreased
Xu Y, Zhang Z, Chen P, Kellon N, He A, Alizai U, Lee S, Sathish K, Yan Z, Zhou X, Kutz L, Tsilimigras DI, Pawlik TM, Zhu H.   +13 more
europepmc   +2 more sources

Decreased serum MG53 levels are associated with SHBG and androgen excess in women with polycystic ovary syndrome [PDF]

Scientific Reports
Polycystic ovary syndrome (PCOS) is a common endocrine disorder characterized by hormonal and metabolic abnormalities. Mitsugumin-53 (MG53), a multifunctional E3 ubiquitin ligase, is implicated in insulin signaling and oxidative stress regulation, yet ...
Enes Serhat Coşkun, Fatma Ketenci Gencer, Süleyman Salman, Nilhan Nurlu, Havva Betül Bacak, Serkan Kumbasar, Gözde Yıldırım Timur, Ecenur Çelikoğlu, Şevval Ünlü, Fatma Tunççağ, Rana Güven   +10 more
doaj   +2 more sources

XBP1s-Orchestrated Soluble Mediators: Participants of Oxidative Stress in Renal Ischemia-Reperfusion Injury Following Donation After Circulatory Death. [PDF]

Mediators Inflamm
Ischemia‐reperfusion injury (IRI) presents an intractable challenge for kidney donors, especially in the era of donation after circulatory death (DCD). Based on in‐depth studies of the renal IRI phenomenon, and the mechanisms involved, an increasing number of soluble mediators are being frequently associated with cellular dysfunction, cell death, and ...
Zhang J, Zhao Y, Zhong J, Ding H, Chen W, Li D, Chen X, Zhu D, Liao G, Gong N.   +9 more
europepmc   +2 more sources

Serum MG53/TRIM72 Is Associated With the Presence and Severity of Coronary Artery Disease and Acute Myocardial Infarction

Frontiers in Physiology, 2020
Background: Mitsugumin 53 or Tripartite motif 72 (MG53/TRIM72), a myokine/cardiokine belonging to the tripartite motif family, can protect the heart from ischemic injury and regulate lipid metabolism in rodents. However, its biological function in humans
Hui Han, Zhu Jinzhou, Zhengbin Zhu
exaly   +3 more sources

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science
Corneal sensory nerve plays a critical role in pain sensation and corneal wound healing. However, the molecular mechanisms that regulate corneal nerve repair, especially couple immune regulation to corneal nerve repair remain poorly understood.
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
doaj   +2 more sources