Redox Biology, 2022 Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) transplantation is a promising therapy for Alzheimer's disease (AD). However, hUC-MSCs cultured in vitro easily exhibit replicative senescence, which restricts their application.
Shanshan Ma, Fangxia Guan
exaly +3 more sources
Applications of Multifunctional Hydrogel in Tissue Engineering and Regenerative Medicine. [PDF]
MedComm (2020)Schematic illustration showing multifunctional hydrogels in the application of tissue engineering and regenerative medicine. ABSTRACT Hydrogels, with excellent hydrophilicity and high‐water content, have emerged as highly versatile biomaterials for tissue engineering and regenerative medicine.
Lyu J, Liu X, Yang Q, Zhang Y, Wang X.
europepmc +2 more sources
MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease [PDF]
Nature CommunicationsAlcoholic liver disease (ALD) remains a significant clinical challenge with limited therapeutics. It is strongly associated with sarcopenia, which further worsens the prognosis in liver cirrhosis. Zinc-deficiency is a hallmark of ALD, impairing the liver’
Tingting Shu +23 more
doaj +2 more sources
E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy. [PDF]
MedComm (2020)E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Wang H +6 more
europepmc +2 more sources
Zinc Binding to MG53 Protein Facilitates Repair of Injury to Cell Membranes [PDF]
Journal of Biological Chemistry, 2015 Zinc is an essential trace element that participates in a wide range of biological functions, including wound healing. Although Zn(2+) deficiency has been linked to compromised wound healing and tissue repair in human diseases, the molecular mechanisms underlying Zn(2+)-mediated tissue repair remain unknown.
Chuanxi, Cai +8 more
openaire +4 more sources
Recombinant human mitsugumin 53: a potential therapeutic agent for multiple diseases [PDF]
Frontiers in PharmacologyMitsugumin 53 (MG53), a member of the tripartite motif family proteins, is predominantly expressed in skeletal and cardiac muscles. Endogenous MG53 was first identified as a crucial component of the sarcolemmal membrane repair machinery.
Junfeng Li +9 more
doaj +2 more sources
Distinct amino acid motifs carrying multiple positive charges regulate membrane targeting of dysferlin and MG53. [PDF]
PLoS ONE, 2018 Dysferlin (Dysf) and mitsugumin53 (MG53) are two key proteins involved in membrane repair of muscle cells which are efficiently recruited to the sarcolemma upon lesioning.
Lu Zhou +4 more
doaj +4 more sources
E3 ligase MG53 suppresses tumor growth by degrading cyclin D1
Signal Transduction and Targeted Therapy, 2023 Due to the essential role of cyclin D1 in regulating transition from G1 to S phase in cell cycle, aberrant cyclin D1 expression is a major oncogenic event in many types of cancers.
Meng Fang +15 more
doaj +3 more sources
MG53’s non-physiologic interaction with insulin receptor: lack of effect on insulin-stimulated Akt phosphorylation in muscle, heart and liver tissues [PDF]
Frontiers in EndocrinologyRationaleMG53’s known function in facilitating tissue repair and anti-inflammation has broad applications to regenerative medicine. There is controversy regarding MG53’s role in the development of type 2 diabetes mellitus.ObjectiveThis study aims to ...
Kyung Eun Lee +10 more
doaj +2 more sources
Multi-Cellular Functions of MG53 in Muscle Calcium Signaling and Regeneration [PDF]
Frontiers in Physiology, 2020 Since its identification in 2009, multiple studies have indicated the importance of MG53 in muscle physiology. The protein is produced in striated muscles but has physiologic implications reaching beyond the confines of striated muscles.
Dathe Z. Benissan-Messan +7 more
doaj +3 more sources