Results 51 to 60 of about 1,176 (169)

MG53 Inhibits Necroptosis Through Ubiquitination-Dependent RIPK1 Degradation for Cardiac Protection Following Ischemia/Reperfusion Injury

Frontiers in Cardiovascular Medicine, 2022
RationaleWhile reactive oxygen species (ROS) has been recognized as one of the main causes of cardiac injury following myocardial infarction, the clinical application of antioxidants has shown limited effects on protecting hearts against ischemia ...
Qiang Wang, Ki Ho Park, Bingchuan Geng, Peng Chen, Chunlin Yang, Qiwei Jiang, Frank Yi, Tao Tan, Xinyu Zhou, Zehua Bian, Jianjie Ma, Hua Zhu   +11 more
doaj   +1 more source

Rosuvastatin exerts cardioprotective effect in lipopolysaccharide-mediated injury of cardiomyocytes in an MG53-dependent manner

BMC Cardiovascular Disorders, 2022
Background Myocarditis is a cardiomyopathy associated with the inflammatory response. Rosuvastatin (RS) demonstrates cardioprotective effect in the clinical setting, although its cellular and molecular mechanisms in ameliorating myocarditis are largely ...
Jiawei Zhuang, Gangyi Cheng, Jian Huang, Hongwei Guo, Yiquan Lai, Jiamao Wang, Zhonggui Shan, Shaoyi Zheng   +7 more
doaj   +1 more source

MG53 Nucleates Assembly Of Cell Membrane Repair Machinery [PDF]

Biophysical Journal, 2008
Dynamic membrane repair and remodelling is an elemental process that maintains cell integrity and mediates efficient cellular function. Here we report that MG53, a muscle-specific tripartite motif family protein (TRIM72), is a component of the sarcolemmal membrane-repair machinery.
Cai, Chuanxi, Masumiya, Haruko, Weisleder, Noah, Matsuda, Noriyuki, Nishi, Miyuki, Hwang, Moonsun, Ko, Jae-Kyun, Lin, Peihui, Thornton, Angela, Zhao, Xiaoli, Pan, Zui, Komazaki, Shinji, Brotto, Marco, Takeshima, Hiroshi, Ma, Jianjie   +14 more
openaire   +3 more sources

MG53 is not expressed in the nervous system. [PDF]

, 2020
(A) Lysates from an adult wild type mouse were used for western blotting to detect levels of MG53. One fourth the amount of muscle lysate was used compared to nervous tissue lysate, and no band was detected in the nervous system lysate.
Brian J. Paleo (8694246), Kathryn M. Madalena (8694249), Jessica K. Lerch (8694264), Kevin E. McElhanon (8694255), Aubrey L. Rose (8694261), Thomas A. Kwiatkowski (8694258), Rohan Mital (8694252), Noah Weisleder (118722)   +7 more
core   +1 more source

MG53 preserves mitochondrial integrity of cardiomyocytes during ischemia reperfusion-induced oxidative stress

Redox Biology, 2022
Ischemic injury to the heart induces mitochondrial dysfunction due to increasing oxidative stress. MG53, also known as TRIM72, is highly expressed in striated muscle, is secreted as a myokine after exercise, and is essential for repairing damaged plasma ...
Kristyn Gumpper-Fedus, Ki Ho Park, Hanley Ma, Xinyu Zhou, Zehua Bian, Karthikeyan Krishnamurthy, Matthew Sermersheim, Jingsong Zhou, Tao Tan, Lei Li, Jianxun Liu, Pei-Hui Lin, Hua Zhu, Jianjie Ma   +13 more
doaj   +1 more source

MG53 Regulates Membrane Budding and Exocytosis in Muscle Cells [PDF]

Journal of Biological Chemistry, 2009
Membrane recycling and remodeling contribute to multiple cellular functions, including cell fusion events during myogenesis. We have identified a tripartite motif (TRIM72) family member protein named MG53 and defined its role in mediating the dynamic process of membrane fusion and exocytosis in striated muscle.
Chuanxi, Cai, Haruko, Masumiya, Noah, Weisleder, Zui, Pan, Miyuki, Nishi, Shinji, Komazaki, Hiroshi, Takeshima, Jianjie, Ma   +7 more
openaire   +2 more sources

MG53 attenuates nitrogen mustard‐induced acute lung injury [PDF]

Journal of Cellular and Molecular Medicine, 2022
AbstractNitrogen mustard (NM) is an alkylating vesicant that causes severe pulmonary injury. Currently, there are no effective means to counteract vesicant‐induced lung injury. MG53 is a vital component of cell membrane repair and lung protection. Here, we show that mice with ablation of MG53 are more susceptible to NM‐induced lung injury than the wild‐
Haichang Li, Lucia Rosas, Zhongguang Li, Zehua Bian, Xiuchun Li, Kyounghan Choi, Chuanxi Cai, Xinyu Zhou, Tao Tan, Valerie Bergdall, Bryan Whitson, Ian Davis, Jianjie Ma   +12 more
openaire   +2 more sources

MG53 increases membrane repair capacity in N2a cells. [PDF]

, 2020
(A) A multiphoton microscope was used to injure transfected Neuro2a cells transfected with GFP or GFP tagged MG53. After injury, the GFP signal can be seen moving to the injury site in the GFP-MG53 cells, whereas no signal was detected in the GFP control
Brian J. Paleo (8694246), Kathryn M. Madalena (8694249), Jessica K. Lerch (8694264), Kevin E. McElhanon (8694255), Aubrey L. Rose (8694261), Thomas A. Kwiatkowski (8694258), Rohan Mital (8694252), Noah Weisleder (118722)   +7 more
core   +1 more source

MG53 marks poor beta cell performance and predicts onset of type 2 diabetes in subjects with different degrees of glucose tolerance [PDF]

, 2022
Aim: MG53 is a myokine modulating insulin signaling in several tissues; its relationship to glucose tolerance or risk of developing type 2 diabetes mellitus (T2DM) is unknown.
Bianchi C., Del Prato S., Raggi F., Solini A., Rossi C., Bonadonna R. C., Frontoni S.   +6 more
core   +3 more sources

MG53-Mediated Protection in Heart Valve Biology [PDF]

Biophysical Journal, 2017
Utilizing both overexpression and extracellular application, we aim to target MG53, an essential cell membrane repair protein, to valvular cells for treatment of tissue injuries associated with valvular heart disease (VHD). Membrane repair is important to maintain normal cellular physiology, and disruption of this process can result in disease in a ...
T.M. Ayodele Adesanya, Melanie Russell, Xinyu Zhou, Hua Zhu, Tao Tan, Ki Ho Park, Joy Lincoln, Jianjie Ma   +7 more
openaire   +1 more source