Correlation analyzes of the parameters with MG53 levels (<8.57 pg/ml excluded). [PDF]
, 2023 Correlation analyzes of the parameters with MG53 levels (
Mine Okur (15355282) +8 more
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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019 Background The aortic valve of the heart experiences constant mechanical stress under physiological conditions. Maladaptive valve injury responses contribute to the development of valvular heart disease. Here, we test the hypothesis that MG53 (mitsugumin
T. M. Ayodele Adesanya +12 more
doaj +1 more source
Muscle multiorgan crosstalk with MG53 as a myokine for tissue repair and regeneration
Current Opinion in Pharmacology, 2021 Through stress and injury to tissues, the cell membrane is damaged and can lead to cell death and a cascade of inflammatory events. Soluble factors that mitigate and repair membrane injury are important to normal homeostasis and are a potential therapeutic intervention for regenerative medicine.
Bryan A. Whitson +4 more
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MG53 Does Not Manifest the Development of Diabetes in db/db Mice [PDF]
Diabetes, 2020 MG53 is a member of the TRIM protein family that is predominantly expressed in striated muscles and participates in cell membrane repair. Controversy exists regarding MG53’s role in insulin signaling and manifestation of diabetes. We generated db/db mice with either whole-body ablation or sustained elevation of MG53 in the bloodstream in order to ...
Qiang Wang +14 more
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MG53 AAV Constructs as a Gene Therapy for Dysferlinopathies [PDF]
, 2023 Plasma membrane repair is a conserved cellular process that uses various mechanisms to restore the barrier function of the plasma membrane when it is disrupted. This allows the cell to survive injuries that would usually compromise membrane integrity and
Kern, Benjamen
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Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review
Frontiers in Physiology, 2022 Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death.
Bowen Xu +9 more
doaj +1 more source
The C2A domain in dysferlin is important for association with MG53 (TRIM72)
PLoS Currents, 2012 In skeletal muscle, Mitsugumin 53 (MG53), also known as muscle-specific tripartite motif 72, reportedly interacts with dysferlin to regulate membrane repair. To better understand the interactions between dysferlin and MG53, we conducted immunoprecipitation (IP) and pull-down assays.
Matsuda, Chie +8 more
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HFD treatment reduces the level of MG53 in blood circulation. [PDF]
, 2015 (A) Western blotting MG53 levels in serum of ND (n = 5) and HFD (n = 7)-treated mice. (B) Quantification of western blot densities reveals reduced MG53 serum levels in mice on HFD.
Yuqi Cui (736228) +12 more
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The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
Oncogenesis, 2022 Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma +9 more
doaj +1 more source
MG53 E3 Ligase-dead Mutant Protects Diabetic Hearts from Acute Ischemic/Reperfusion Injury and Ameliorates Diet-induced Cardiometabolic Damage [PDF]
, 2021 Cardiometabolic diseases, including diabetes and its cardiovascular complications, are the global leading cause of death, highlighting a major unmet medical need.
Shuo Zhang (30844) +14 more
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