Mechanisms of Endothelial Cell Membrane Repair: Progress and Perspectives [PDF]
Cells, 2023 Endothelial cells are the crucial inner lining of blood vessels, which are pivotal in vascular homeostasis and integrity. However, these cells are perpetually subjected to a myriad of mechanical, chemical, and biological stresses that can compromise ...
Duoduo Zha +5 more
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Annexin A4 and A6 induce membrane curvature and constriction during cell membrane repair [PDF]
Nature Communications, 2017 The role of annexins in cell membrane repair is largely undefined. Here the authors use a model lipid bilayer to show that annexin A4 induces curvature at the membrane free edge and annexin A6 induces constriction force, and find that both annexins are ...
Theresa Louise Boye +7 more
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Annexin A2 Mediates Dysferlin Accumulation and Muscle Cell Membrane Repair [PDF]
Cells, 2020 Muscle cell plasma membrane is frequently damaged by mechanical activity, and its repair requires the membrane protein dysferlin. We previously identified that, similar to dysferlin deficit, lack of annexin A2 (AnxA2) also impairs repair of skeletal ...
Daniel C. Bittel +7 more
doaj +4 more sources
Role of calcium-sensor proteins in cell membrane repair. [PDF]
Biosci Rep, 2023 AbstractCell membrane repair is a critical process used to maintain cell integrity and survival from potentially lethal chemical, and mechanical membrane injury. Rapid increases in local calcium levels due to a membrane rupture have been widely accepted as a trigger for multiple membrane-resealing models that utilize exocytosis, endocytosis, patching ...
Li Z, Shaw GS.
europepmc +3 more sources
A pore-forming protein-induced surface-enhanced Raman spectroscopic strategy for dynamic tracing of cell membrane repair [PDF]
iScience, 2021 Summary: The plasma membrane repair holds significance for maintaining cell survival and homeostasis. To achieve the sensitive visualization of membrane repair process for revealing its mechanism, this work designs a perforation-induced surface-enhanced ...
Yuanjiao Yang +4 more
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Cell-derived extracellular vesicles and membranes for tissue repair [PDF]
Journal of Nanobiotechnology, 2021 Humans have a limited postinjury regenerative ability. Therefore, cell-derived biomaterials have long been utilized for tissue repair. Cells with multipotent differentiation potential, such as stem cells, have been administered to patients for the ...
Yuan Ding +7 more
doaj +3 more sources
Plasma Membrane Wounding and Repair Assays for Eukaryotic Cells
Bio-Protocol, 2022 Damage to the plasma membrane and loss of membrane integrity are detrimental to eukaryotic cells. It is, therefore, essential that cells possess an efficient membrane repair system to survive.
Stine Sønder +4 more
doaj +4 more sources
MG53 nucleates assembly of cell membrane repair machinery [PDF]
Nature Cell Biology, 2008 Dynamic membrane repair and remodelling is an elemental process that maintains cell integrity and mediates efficient cellular function. Here we report that MG53, a muscle-specific tripartite motif family protein (TRIM72), is a component of the sarcolemmal membrane-repair machinery.
Noriyuki Matsuda +2 more
exaly +4 more sources
Wound Repair of the Cell Membrane: Lessons from Dictyostelium Cells
CellsThe cell membrane is frequently subjected to damage, either through physical or chemical means. The swift restoration of the cell membrane’s integrity is crucial to prevent the leakage of intracellular materials and the uncontrolled influx of ...
Shigehiko Yumura
doaj +3 more sources
Cell membrane disruption stimulates NO/PKG signaling and potentiates cell membrane repair in neighboring cells. [PDF]
PLoS ONE, 2012 Resealing of a disrupted plasma membrane at the micron-diameter range requires Ca(2+)-regulated exocytosis. Repeated membrane disruptions reseal more quickly than the initial wound, and this potentiation of membrane resealing persists for at least 24 ...
Tatsuru Togo
doaj +5 more sources