The plasma membrane surrounds every single cell and essentially shapes cell life by separating the interior from the external environment. Thus, maintenance of cell membrane integrity is essential to prevent death caused by disruption of the plasma ...
Poul Martin Bendix +16 more
doaj +3 more sources
TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis [PDF]
Background Chronic tissue injury was shown to induce progressive scarring in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), while an array of repair/regeneration and stress responses come to equilibrium to determine the outcome of injury ...
Xiaofei Cong +9 more
doaj +2 more sources
Helicobacter pylori Disrupts Host Cell Membranes, Initiating a Repair Response and Cell Proliferation [PDF]
Helicobacter pylori (H. pylori), the human stomach pathogen, lives on the inner surface of the stomach and causes chronic gastritis, peptic ulcer, and gastric cancer. Plasma membrane repair response is a matter of life and death for human cells against physical and biological damage. We here test the hypothesis that H.
Li-Ling Lin +7 more
openaire +4 more sources
Ca2+–Calmodulin Dependent Wound Repair in Dictyostelium Cell Membrane [PDF]
Wound repair of cell membrane is a vital physiological phenomenon. We examined wound repair in Dictyostelium cells by using a laserporation, which we recently invented. We examined the influx of fluorescent dyes from the external medium and monitored the cytosolic Ca2+ after wounding.
Shigehiko Yumura, Yumura Shigehiko
exaly +4 more sources
4-Phenylbutyrate restores localization and membrane repair to human dysferlin mutations [PDF]
Summary: Dysferlinopathies are muscular dystrophies caused by recessive loss-of-function mutations in dysferlin (DYSF), a membrane protein involved in skeletal muscle membrane repair.
Kana Tominaga +7 more
doaj +3 more sources
Agonal cell resuscitation strategy to promote tissue repair [PDF]
Overactive lytic regulated cell death (RCD) causes excessive inflammation and impairs tissue repair. Current strategies rely on small-molecule inhibitors targeting the initiation of lytic RCD but these show off-target effects and reduced pro-repair ...
Zhenxiang Huang +15 more
doaj +2 more sources
Tollip antagonizes ESCRT-III-mediated plasma membrane repair and cell recovery [PDF]
Cells can recover from sub-lethal necrosis by repairing plasma-membrane (PM) rupture through the ESCRT-III machinery, but how this process is regulated remains unknown. Here, we identify Toll-interacting protein (Tollip) as a conserved negative regulator
Julia M. Ferrick +8 more
doaj +2 more sources
Difference in Membrane Repair Capacity Between Cancer Cell Lines and a Normal Cell Line [PDF]
Electroporation-based treatments and other therapies that permeabilize the plasma membrane have been shown to be more devastating to malignant cells than to normal cells. In this study, we asked if a difference in repair capacity could explain this observed difference in sensitivity.
Ivana Novak, Julie Gehl, Mcneil Paul L
exaly +5 more sources
Annexin-A6 in Membrane Repair of Human Skeletal Muscle Cell: A Role in the Cap Subdomain
Defects in membrane repair contribute to the development of some muscular dystrophies, highlighting the importance to decipher the membrane repair mechanisms in human skeletal muscle. In murine myofibers, the formation of a cap subdomain composed notably
Coralie Croissant +4 more
doaj +3 more sources
Lectin-based food poisoning: a new mechanism of protein toxicity. [PDF]
BACKGROUND: Ingestion of the lectins present in certain improperly cooked vegetables can result in acute GI tract distress, but the mechanism of toxicity is unknown.
Katsuya Miyake +2 more
doaj +1 more source

