Trim72 is a major host factor protecting against lethal Candida albicans infection [PDF]
PLoS PathogensCandida albicans is the most common aetiologic pathogen of fungal infections associated with high mortality in immunocompromised patients. There is an urgent need to develop new antifungal therapies owing to the poor efficacy and resistance of current ...
Ju Cao
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TRIM72 inhibits cell migration and epithelial-mesenchymal transition by attenuating FAK/akt signaling in colorectal cancer [PDF]
HeliyonTRIM72 (MG53), a membrane repair protein with E3-ligase activity, plays a crucial role in colorectal cancer (CRC). This study examined TRIM72 expression in primary CRC tumors and paired liver metastases using RT-PCR. Findings revealed significantly lower
Xiaoming Lyu
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Structural basis for TRIM72 oligomerization during membrane damage repair [PDF]
Nature Communications, 2023 TRIM72 oligomerization via intermolecular disulfide bonds is important for cells to repair damaged membranes. Here, authors report the crystal structure of TRIM72 dimer and show that TRIM72 B-box dimerization facilitates TRIM72 oligomerization.
Zhenhai Li, Chun Zhou, Yuemin Ma
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MuRF1 Partners With TRIM72 to Impair Insulin Signaling in Skeletal Muscle Cells. [PDF]
FASEB JABSTRACT Muscle RING‐finger protein 1 (MuRF1, gene name: TRIM63 ) is well known as a critical molecular regulator in skeletal muscle atrophy. Despite the identification of several substrates and interaction partners for MuRF1, the precise molecular mechanisms by which MuRF1 ...
Musa I +3 more
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TRIM72 restricts lyssavirus infection by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein [PDF]
PLoS PathogensThe tripartite motif (TRIM) protein family is the largest subfamily of E3 ubiquitin ligases, playing a crucial role in the antiviral process. In this study, we found that TRIM72, a member of the TRIM protein family, was increased in neuronal cells and ...
Zhen Fu, Ling Zhao
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Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane [PDF]
Nature Structural and Molecular Biology, 2023 Abstract Defects in plasma membrane repair can lead to muscle and heart diseases in humans. Tripartite motif-containing protein (TRIM)72 (mitsugumin 53; MG53) has been determined to rapidly nucleate vesicles at the site of membrane damage, but the underlying molecular mechanisms remain poorly understood.
Hyun Kyu Song +2 more
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Insights into the membrane repair mechanism by the coiled-coil-mediated oligomerization of TRIM72 [PDF]
Biochemistry and Biophysics ReportsTRIpartite Motif-containing 72 (TRIM72, also known as MG53), a RING-type E3 ubiquitin ligase, is critical for plasma membrane repair. Like other TRIM family proteins, TRIM72 has a conserved architecture comprising RING, B-box, coiled-coil, and C-terminal PRY-SPRY domains.
Hyun Kyu Song +2 more
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Biochemistry and Biophysics Reports, 2020 TRIM family of E3 ubiquitin ligases have an amino-terminal conserved tripartite motif consisting of RING, B-Box, coiled-coil domain and different C-terminal domain leading it to classification into 11 subclasses.
Titia K Sixma +2 more
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TRIM72 promotes alveolar epithelial cell membrane repair and ameliorates lung fibrosis [PDF]
Respiratory Research, 2020 Background Chronic tissue injury was shown to induce progressive scarring in fibrotic diseases such as idiopathic pulmonary fibrosis (IPF), while an array of repair/regeneration and stress responses come to equilibrium to determine the outcome of injury ...
Xiaofei Cong +9 more
doaj +3 more sources
Whole-exome sequencing identifies TRIM72 as a candidate gene for autosomal recessive limb-girdle muscular dystrophy [PDF]
Human GenomicsBackground Limb-girdle muscular dystrophies (LGMDs) constitute a genetically diverse group of disorders characterized by progressive proximal muscle weakness and atrophy.
Abdelaziz Tlili, Abdullah Al Mutery
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