TRIM72 negatively regulates myogenesis via targeting insulin receptor substrate-1 [PDF]
Cell Death and Differentiation, 2010 Lipid rafts have been known to be platforms to initiate cellular signal transduction of insulin-like growth factor (IGF) inducing skeletal muscle differentiation and hypertrophy. Here, tripartite motif 72 (TRIM72), with a really interesting new gene (RING)-finger domain, a B-box, two coiled-coil domains, and a SPRY (SPla and RYanodine receptor) domain,
Lee C S, Lee J-H
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MLL1 promotes placental trophoblast ferroptosis and aggravates preeclampsia symptoms through epigenetic regulation of RBM15/TRIM72/ADAM9 axis [PDF]
Biology DirectThis study explores the epigenetic mechanism of MLL1 regulating trophoblast ferroptosis in preeclampsia (PE). A murine model of PE was established, and HTR-8/SVneo cells were induced by Erastin to establish an in vitro cell model. GSH, MDA, Fe2+, and ROS
Lingling Li +3 more
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Enhancing Membrane Repair Using Recombinant MG53/TRIM72 (rhMG53) Reduces Neurotoxicity in Alzheimer’s Disease Models [PDF]
BiomoleculesAlzheimer’s Disease (AD) is the most common neurodegenerative disease that involves neuronal cell death initiated by the breakdown of the plasma membrane.
Hannah R. Bulgart +2 more
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Integrated transcriptomic and proteomic analysis reveals potential targets for heart regeneration [PDF]
Biomolecules & Biomedicine, 2023 Research on the regenerative capacity of the neonatal heart could open new avenues for the treatment of myocardial infarction (MI). However, the mechanism of cardiac regeneration remains unclear.
Liu Liu +12 more
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MG53/TRIM72: multi-organ repair protein and beyond [PDF]
Frontiers in PhysiologyMG53, a member of the tripartite motif protein family, possesses multiple functionalities due to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase properties.
Yong-Fei Wang +9 more
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Nanodysferlins support membrane repair and binding to TRIM72/MG53 but do not localize to t-tubules or stabilize Ca2+ signaling [PDF]
Molecular Therapy: Methods & Clinical DevelopmentMutations in the DYSF gene, encoding the protein dysferlin, lead to several forms of muscular dystrophy. In healthy skeletal muscle, dysferlin concentrates in the transverse tubules and is involved in repairing the sarcolemma and stabilizing Ca2 ...
Joaquin Muriel +10 more
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Role of a TRIM72 ADP-ribosylation cycle in myocardial injury and membrane repair [PDF]
JCI Insight, 2018 Mono-ADP-ribosylation of an (arginine) protein catalyzed by ADP-ribosyltransferase 1 (ART1) — i.e., transfer of ADP-ribose from NAD to arginine — is reversed by ADP-ribosylarginine hydrolase 1 (ARH1) cleavage of the ADP-ribose–arginine bond.
Elizabeth Murphy +2 more
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Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy [PDF]
Journal of Cachexia, Sarcopenia and Muscle, 2022 Background Histone deacetylase 4 (HDAC4) is a stress‐responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never been ...
Alessandra Renzini +15 more
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Reduced Sarcolemmal Membrane Repair Exacerbates Striated Muscle Pathology in a Mouse Model of Duchenne Muscular Dystrophy [PDF]
Cells, 2022 Duchenne muscular dystrophy (DMD) is a common X-linked degenerative muscle disorder that involves mutations in the DMD gene that frequently reduce the expression of the dystrophin protein, compromising the structural integrity of the sarcolemmal membrane
Brian J. Paleo +9 more
doaj +2 more sources
Lipid-binding properties of TRIM72
BMB Reports, 2012 TRIM72 is known to play a critical role in skeletal muscle membrane repair. To better understand the molecular mechanisms of this protein, we carried out an in vitro binding study with TRIM72. Our study proved that TRIM72 binds various lipids with dissociation constants (K(d)) ranging from 88.2 ± 9.9 nM to 550.5 ± 134.5 nM.
Young-Gyu Ko, Heonyong Park
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