The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury [PDF]
Journal of Immunology Research, 2021 Acute lung injury (ALI) is an inflammatory disorder of the lung that causes high mortality and lacks any pharmacological intervention. Ubiquitination plays a critical role in the pathogenesis of ALI as it regulates the alveolocapillary barrier and the ...
Yingjie Huang +4 more
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It’s a TRIM-endous view from the top: the varied roles of TRIpartite Motif proteins in brain development and disease [PDF]
Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Jane Dudley-Fraser, Katrin Rittinger
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Genome-Wide Identification and Expression Analysis of Potential Antiviral Tripartite Motif Proteins (TRIMs) in Grass Carp (Ctenopharyngodon idella) [PDF]
Biology, 2021 Tripartite motif proteins (TRIMs), especially B30.2 domain-containing TRIMs (TRIMs-B30.2), are increasingly well known for their antiviral immune functions in mammals, while antiviral TRIMs are far from being identified in teleosts. In the present study,
Beibei Qin +5 more
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Frontiers in Cell and Developmental Biology, 2020 Protein quality control (PQC) is pivotal for eukaryotic cells to eliminate misfolded proteins and maintain cellular homeostasis. A decreased or increased capacity of PQC is associated with various diseases, e.g., neurodegenerative diseases and cancers ...
Litian Zhang +7 more
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Regulation of Tripartite Motif-Containing Proteins on Immune Response and Viral Evasion
Frontiers in Microbiology, 2021 Tripartite motif-containing proteins (TRIMs), exhibiting ubiquitin E3 ligase activity, are involved in regulation of not only autophagy and apoptosis but also pyrotosis and antiviral immune responses of host cells.
Xiu-Zhong Zhang +2 more
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TRIM family proteins: dual roles in tumor immunity [PDF]
Frontiers in Cell and Developmental BiologyTripartite motif (TRIM) proteins represent one of the largest subfamilies of E3 ubiquitin ligases and exert complex yet critical dual roles in tumor immunology by orchestrating protein ubiquitination.
Runjie Cai +4 more
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Tripartite Motif-Containing Protein 65 (TRIM65) Inhibits Hepatitis B Virus Transcription
VirusesTripartite motif (TRIM) proteins, comprising a family of over 100 members with conserved motifs, exhibit diverse biological functions. Several TRIM proteins influence viral infections through direct antiviral mechanisms or by regulating host antiviral ...
Sheng Shen +11 more
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TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders [PDF]
Frontiers in ImmunologyTripartite motif (TRIM) proteins constitute a versatile family of E3 ubiquitin ligases that regulate key signaling pathways governing innate and adaptive immune responses.
Bilal Jawed +13 more
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BiomoleculesThe worldwide impact of liver diseases is increasing steadily, with a consistent upswing evidenced in incidence and mortality rates. Chronic liver diseases (CLDs) refer to the liver function’s progressive deterioration exceeding six months, which ...
Xiwen Cao +3 more
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The Roles of Tripartite Motif Proteins in Urological Cancers: A Systematic Review [PDF]
CancersShoji Kimura +2 more
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