Results 1 to 10 of about 269 (67)
Journal of Advanced Research, 2023 Background: Tripartite motif (TRIM) family proteins have more than 80 members and are widely found in various eukaryotic cells. Most TRIM family proteins participate in the ubiquitin-proteasome degradation system as E3-ubiquitin ligases; therefore, they ...
Junjie Gu +4 more
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Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
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Tumor suppressor p53 cross-talks with TRIM family proteins
Genes and Diseases, 2021 p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu +4 more
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The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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TRIM proteins in hepatocellular carcinoma
Journal of Biomedical Science, 2022 The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu +5 more
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Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
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Origin and diversification of TRIM ubiquitin ligases. [PDF]
PLoS ONE, 2012 Most proteins of the TRIM family (also known as RBCC family) are ubiquitin ligases that share a peculiar protein structure, characterized by including an N-terminal RING finger domain closely followed by one or two B-boxes.
Ignacio Marín
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Genome Biology, 2019 Trim-Away is a recent technique to rapidly deplete a protein from any cell type. Guided by antibodies, TRIM21 selects proteins for destruction. However, the applicability of this method in model organisms has not been investigated.
Xiao Chen +7 more
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To TRIM the Immunity: From Innate to Adaptive Immunity
Frontiers in Immunology, 2020 The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang +3 more
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TRIM family proteins: roles in proteostasis and neurodegenerative diseases
Open Biology, 2022 Neurodegenerative diseases (NDs) are a diverse group of disorders characterized by the progressive degeneration of the structure and function of the central or peripheral nervous systems. One of the major features of NDs, such as Alzheimer's disease (AD),
Yan Zhu +4 more
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