Results 11 to 20 of about 368 (166)
The role of TRIM family in metabolic associated fatty liver disease
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
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Comparative structural analyses of the NHL domains from the human E3 ligase TRIM–NHL family
IUCrJ, 2022 Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of the RING-type E3 ubiquitin ligases that play a role in diverse processes from homeostasis and immune response to viral restriction.
Apirat Chaikuad +3 more
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Human Genomics, 2022 Background The tripartite motif (TRIM) proteins function as important regulators in innate immunity, tumorigenesis, cell differentiation and ontogenetic development.
Yueying Gao +10 more
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Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers
Cells, 2022 Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
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PLoS ONE, 2011 Tripartite motif proteins (TRIM) constitute a large family of proteins containing a RING-Bbox-Coiled Coil motif followed by different C-terminal domains. Involved in ubiquitination, TRIM proteins participate in many cellular processes including antiviral
Pierre Boudinot +7 more
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TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
PLoS Pathogens, 2008 Members of the TRIpartite interaction Motif (TRIM) family of E3 ligases have been shown to exhibit antiviral activities. Here we report a near comprehensive screen for antiretroviral activities of 55 TRIM proteins (36 human, 19 mouse).
Pradeep D Uchil +4 more
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Frontiers in OncologyGastric cancer (GC) is a globally prevalent malignant tumor, causing approximately 770,000 deaths in 2020, ranking fourth among all cancers. The tripartite motif (TRIM) protein family is involved in various cellular regulations and has become a key ...
Caiqing Zhao +5 more
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Evolution and expression of the duck TRIM gene repertoire
Frontiers in Immunology, 2023 Tripartite motif (TRIM) proteins are involved in development, innate immunity, and viral restriction. TRIM gene repertoires vary between species, likely due to diversification caused by selective pressures from pathogens; however, this has not been ...
Lee K. Campbell +5 more
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Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation
FEBS Letters, EarlyView.Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz +11 more
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The TRIMendous Role of TRIMs in Virus–Host Interactions
Vaccines, 2017 The innate antiviral response is integral in protecting the host against virus infection. Many proteins regulate these signaling pathways including ubiquitin enzymes.
Sarah van Tol +4 more
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