Frontiers in Molecular Neuroscience, 2023 The tripartite motif (TRIM) protein family members have been implicated in a multitude of physiologies and pathologies in different tissues. With diverse functions in cellular processes including regulation of signaling pathways, protein degradation, and
Katrin Rittinger +2 more
exaly +5 more sources
Interleukin 27, Similar to Interferons, Modulates Gene Expression of Tripartite Motif (TRIM) Family Members and Interferes with Mayaro Virus Replication in Human Macrophages [PDF]
VirusesBackground: The Tripartite motif (TRIM) family includes more than 80 distinct human genes. Their function has been implicated in regulating important cellular processes, including intracellular signaling, transcription, autophagy, and innate immunity.
Johana Hernandez-Sarmiento +2 more
exaly +5 more sources
TRIM proteins as emerging regulators of immune pathways: potential therapeutic targets in immune-related disorders [PDF]
Frontiers in ImmunologyTripartite motif (TRIM) proteins constitute a versatile family of E3 ubiquitin ligases that regulate key signaling pathways governing innate and adaptive immune responses.
Bilal Jawed +13 more
doaj +2 more sources
TRIM family proteins: dual roles in tumor immunity [PDF]
Frontiers in Cell and Developmental BiologyTripartite motif (TRIM) proteins represent one of the largest subfamilies of E3 ubiquitin ligases and exert complex yet critical dual roles in tumor immunology by orchestrating protein ubiquitination.
Runjie Cai +4 more
doaj +2 more sources
TRIM28 orchestrates SUMO-ubiquitin crosstalk to stabilize PPARG and drive bladder cancer progression [PDF]
Cell Death and DiseaseBladder cancer (BLCA) is a growing health burden with rising incidence and limited therapeutic options. To define the role of the Tripartite Motif (TRIM) family in BLCA, we integrated multi-cohort transcriptomic analyses with functional and mechanistic ...
Xuefeng Fan +10 more
doaj +2 more sources
Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases [PDF]
BiomoleculesCardiovascular diseases have high mortality rates and present a high burden on society and the global healthcare system. A large quantity of drugs have been developed, such as aspirin, ACE inhibitors, beta-blockers, and statins.
Yiyang Cui +4 more
doaj +2 more sources
Structural analysis of TRIM family PRYSPRY domains and its implications for E3-ligand design [PDF]
Journal of Structural Biology: XTripartite motif (TRIM) proteins constitute one of the largest subfamilies of RING-type E3 ubiquitin ligases and are attractive targets for the development of novel degraders that exploit the ubiquitin–proteasome pathway.
Rezart Zhubi +4 more
doaj +2 more sources
Cellular Function of TRIM E3 Ubiquitin Ligases in Health and Disease
Cells, 2022 The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest during the last two decades [...]
Germana Meroni, Solange Desagher
doaj +1 more source
The role of tripartite motif-containing 28 in cancer progression and its therapeutic potentials
Frontiers in Oncology, 2023 Tripartite motif-containing 28 (TRIM28) belongs to tripartite motif (TRIM) family. TRIM28 not only binds and degrades its downstream target, but also acts as a transcription co-factor to inhibit gene expression.
Yiqing Yang +24 more
doaj +1 more source
Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
doaj +1 more source