The Emerging Roles of Tripartite Motif Proteins (TRIMs) in Acute Lung Injury [PDF]
Journal of Immunology Research, 2021 Acute lung injury (ALI) is an inflammatory disorder of the lung that causes high mortality and lacks any pharmacological intervention. Ubiquitination plays a critical role in the pathogenesis of ALI as it regulates the alveolocapillary barrier and the ...
Yingjie Huang +4 more
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Bioinformatics analysis of immune infiltrates and tripartite motif (TRIM) family genes in hepatocellular carcinoma. [PDF]
J Gastrointest Oncol, 2022 The tripartite motif (TRIM) family are important members of the Gene-finger-containing E3 ubiquitin-conjugating enzyme and are involved in the progression of hepatocellular carcinoma (HCC). Previous studies have largely focused on gene expression and molecular pathways, while the underlying role of the TRIM family in the tumor immune microenvironment ...
Cao J +14 more
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Prognostic value of tripartite motif (TRIM) family gene signature from bronchoalveolar lavage cells in idiopathic pulmonary fibrosis. [PDF]
BMC Pulm Med, 2022 Abstract Background Tripartite motif (TRIM) family genes get involved in the pathogenesis and development of various biological processes; however, the prognostic value of TRIM genes for idiopathic pulmonary fibrosis (IPF) needs to be explored.
Zhou M, Ouyang J, Zhang G, Zhu X.
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An investigation of the molecular characterization of the tripartite motif (TRIM) family and primary validation of TRIM31 in gastric cancer. [PDF]
Hum GenomicsAbstractMost TRIM family members characterized by the E3-ubiquitin ligases, participate in ubiquitination and tumorigenesis. While there is a dearth of a comprehensive investigation for the entire family in gastric cancer (GC). By combining the TCGA and GEO databases, common TRIM family members (TRIMs) were obtained to investigate gene expression, gene
Ding Y +11 more
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Regulation of innate immune signalling pathways by the tripartite motif (TRIM) family proteins. [PDF]
EMBO Mol Med, 2011 The innate immune system recognizes microbial components through pattern-recognition receptors (PRRs), including membrane-bound Toll-like receptors and cytosolic receptors such as RIG-I-like receptors and deoxyribonucleic acid (DNA) sensors. These PRRs trigger distinct signal transduction pathways that culminate in induction of an array of cytokines ...
Kawai T, Akira S.
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Determinants of the higher order association of the restriction factor TRIM5alpha and other tripartite motif (TRIM) proteins. [PDF]
J Biol Chem, 2011 Many tripartite motif (TRIM) proteins self-associate, forming dimers and higher order complexes. For example, dimers of TRIM5α, a host factor that restricts retrovirus infection, assemble into higher order arrays on the surface of the viral capsid, resulting in an increase in avidity.
Li X, Yeung DF, Fiegen AM, Sodroski J.
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TRIM proteins in hepatocellular carcinoma
Journal of Biomedical Science, 2022 The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu +5 more
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TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases
Cells, 2021 Tripartite motif (TRIM) proteins are RING E3 ubiquitin ligases defined by a shared domain structure. Several of them are implicated in rare genetic diseases, and mutations in TRIM32 and TRIM-like malin are associated with Limb-Girdle Muscular Dystrophy ...
Lorena Kumarasinghe +5 more
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Frontiers in Oncology, 2021 Emerging evidence suggests that the tripartite motif (TRIM) family play important roles in tumor development and progression. Tripartite motif-containing 50 (TRIM50) is a member of the TRIM family, but little is known regarding its expression and ...
Rongkun Li +5 more
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trim-21 promotes proteasomal degradation of CED-1 for apoptotic cell clearance in C. elegans
eLife, 2022 The phagocytic receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Whether appropriate levels of CED-1 are maintained for executing the engulfment function remains unknown ...
Lei Yuan +4 more
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