Results 31 to 40 of about 4,964 (161)

Silencing of tripartite motif (TRIM) 29 inhibits proliferation and invasion and increases chemosensitivity to cisplatin in human lung squamous cancer NCI-H520 cells. [PDF]

Thorac Cancer, 2015
AbstractBackgroundTRIM29 belongs to the tripartite motif (TRIM) protein family. It has been reported to be a tumor suppressor or have oncogenic function in many cancer types. The aim of this study was to investigate whether downregulation of TRIM29 by small interfering ribonucleic acid (siRNA) could inhibit cell proliferation and invasion and increase ...
Liu C, Huang X, Hou S, Hu B, Li H.
europepmc   +4 more sources

Genomic analysis of the TRIM family reveals two groups of genes with distinct evolutionary properties

BMC Evolutionary Biology, 2008
Background The TRIM family is composed of multi-domain proteins that display the Tripartite Motif (RING, B-box and Coiled-coil) that can be associated with a C-terminal domain.
Fontanella Bianca, Cairo Stefano, Sardiello Marco, Ballabio Andrea, Meroni Germana   +4 more
doaj   +1 more source

TRIM Proteins and Their Roles in the Influenza Virus Life Cycle

Microorganisms, 2020
The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects ...
Hye-Ra Lee, Myoung Kyu Lee, Chan Woo Kim, Meehyein Kim   +3 more
doaj   +1 more source

To TRIM the Immunity: From Innate to Adaptive Immunity

Frontiers in Immunology, 2020
The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang, Zhiwen Gu, Huiyuan Zhang, Hongbo Hu   +3 more
doaj   +1 more source

Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]

PLoS ONE, 2013
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang, Ju-Tao Guo, Jim Z Wu, Guang Yang   +3 more
doaj   +1 more source

Efp/TRIM25 and Its Related Protein, TRIM47, in Hormone-Dependent Cancers

Cells, 2022
Increasing attention has been paid to the biological roles of tripartite motif-containing (TRIM) family proteins, which typically function as E3 ubiquitin ligases. Estrogen-responsive finger protein (Efp), a member of the TRIM family proteins, also known
Kotaro Azuma, Satoshi Inoue
doaj   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Comparative structural analyses of the NHL domains from the human E3 ligase TRIM–NHL family

IUCrJ, 2022
Tripartite motif (TRIM) proteins constitute one of the largest subfamilies of the RING-type E3 ubiquitin ligases that play a role in diverse processes from homeostasis and immune response to viral restriction.
Apirat Chaikuad, Rezart Zhubi, Claudia Tredup, Stefan Knapp   +3 more
doaj   +1 more source

DHODH Drives Sunitinib Resistance Via a Non‐Enzymatic Mechanism by Inhibiting TRIM28 Ubiquitination and Consequent VEGFA Activation in RCC

Advanced Science, EarlyView.
This non‑enzymatic function of DHODH drives sunitinib resistance by competing with TRIM37 to block TRIM28 ubiquitination, thereby stabilizing TRIM28 and activating VEGFA transcription. Disrupting the DHODH–TRIM28 interaction with lisaftoclax restores drug sensitivity.
Shijie Qian, Shihang Pu, Zhipeng Xu, Yiheng Ding, Ling Jin, Baochao Li, Qi Li, Xiaohai Xi, Zengjun Wang, Jiajun Xing, Aiming Xu   +10 more
wiley   +1 more source

OVERVIEW OF CLASS-I TRIPARTITE MOTIF (TRIM) PROTEINS SPECIFICALLY TRIM67

Pakistan Journal of Agriculture, Agricultural Engineering and Veterinary Sciences
The TRIM family is a group of genes expressed during embryogenesis. This review emphasized data on Class-I TRIM genes, including TRIM1, TRIM9, TRIM36, TRIM46, TRIM67, TRIM18, and TRIM76. This article will discuss the structure and function of these genes and their roles in various physiological processes such as embryonic development, and immune ...
S. N. Panhwar, C. Huang, Q. Luo, X. Yu, L. Jia, W. Liu, Z. Chen   +6 more
openaire   +2 more sources