Results 51 to 60 of about 4,964 (161)

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

A No-Brainer! The Therapeutic Potential of TRIM Proteins in Viral and Central Nervous System Diseases

Viruses
Tripartite motif (TRIM) proteins comprise an important class of E3 ubiquitin ligases that regulate numerous biological processes including protein expression, cellular signaling pathways, and innate immunity.
Adam Hage, Mikhaila Janes, Sonja M. Best
doaj   +1 more source

TRIM16 acts as an E3 ubiquitin ligase and can heterodimerize with other TRIM family members.

PLoS ONE, 2012
The TRIM family of proteins is distinguished by its tripartite motif (TRIM). Typically, TRIM proteins contain a RING finger domain, one or two B-box domains, a coiled-coil domain and the more variable C-terminal domains.
Jessica L Bell, Alena Malyukova, Jessica K Holien, Jessica Koach, Michael W Parker, Maria Kavallaris, Glenn M Marshall, Belamy B Cheung   +7 more
doaj   +1 more source

Pan-cancer illumination of TRIM gene family reveals immunology regulation and potential therapeutic implications

Human Genomics, 2022
Background The tripartite motif (TRIM) proteins function as important regulators in innate immunity, tumorigenesis, cell differentiation and ontogenetic development.
Yueying Gao, Tao Pan, Gang Xu, Si Li, Jing Guo, Ya Zhang, Qi Xu, Jiwei Pan, Yanlin Ma, Juan Xu, Yongsheng Li   +10 more
doaj   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

Tumor suppressor p53 cross-talks with TRIM family proteins

Genes and Diseases, 2021
p53 is a key tumor suppressor. As a transcription factor, p53 accumulates in cells in response to various stress signals and selectively transcribes its target genes to regulate a wide variety of cellular stress responses to exert its function in tumor ...
Juan Liu, Cen Zhang, Xue Wang, Wenwei Hu, Zhaohui Feng   +4 more
doaj   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

TRIM32 controls timely cell cycle exit in muscular differentiation through downregulation of c‐Myc mRNA

The FEBS Journal, EarlyView.
Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong, Elisa Lazzari, Sabrina Pacor, Simeone Dal Monego, Erica Piovesan, Danilo Licastro, Germana Meroni   +6 more
wiley   +1 more source

Exploring TRIM proteins’ role in antiviral defense against influenza A virus and respiratory coronaviruses

Frontiers in Cellular and Infection Microbiology
Numerous tripartite motif (TRIM) proteins, identified as E3 ubiquitin ligases, participate in various viral infections through ubiquitylation, ISGylation, and SUMOylation processes.
Ying Wei, Ying Wei, Ying Wei, Junzhu Song, Junzhu Song, Junzhu Song, Jingyu Zhang, Jingyu Zhang, Jingyu Zhang, Songbiao Chen, Songbiao Chen, Songbiao Chen, Zuhua Yu, Zuhua Yu, Zuhua Yu, Lei He, Lei He, Lei He, Jian Chen, Jian Chen, Jian Chen   +20 more
doaj   +1 more source

Chopin's Craft of Musical Form: Making Romantic Music with Classical Theme Types and Galant Schemata

Music Analysis, EarlyView.
ABSTRACT Frédéric Chopin adhered to traditional practices in musical form to a far greater extent than hitherto acknowledged. He took certain standard formal paths with remarkable consistency throughout his compositional career and across almost all his favoured genres.
Matthew Riley
wiley   +1 more source