Results 21 to 30 of about 4,964 (161)
Emerging Roles of Tripartite Motif-Containing Family Proteins (TRIMs) in Eliminating Misfolded Proteins [PDF]
Frontiers in Cell and Developmental Biology, 2020 Protein quality control (PQC) is pivotal for eukaryotic cells to eliminate misfolded proteins and maintain cellular homeostasis. A decreased or increased capacity of PQC is associated with various diseases, e.g., neurodegenerative diseases and cancers. Recently, increasing evidences have suggested that tripartite motif-containing family proteins (TRIMs)
Litian Zhang +7 more
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Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
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Evolution of a cytoplasmic tripartite motif (TRIM) protein in cows that restricts retroviral infection [PDF]
Proceedings of the National Academy of Sciences, 2006 Primate tripartite motif 5α (TRIM5α) proteins mediate innate intracellular resistance to retroviruses. In humans, TRIM5 is located in a paralogous cluster that includes TRIM6 , TRIM34 , and ...
Si, Zhihai +11 more
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Analysis of tripartite motif (TRIM) family gene expression in prostate cancer bone metastases
Carcinogenesis, 2021 Abstract Tripartite motif (TRIM) family proteins are post-translational protein modifiers with E3-ubiquitin ligase activity, thereby involved in various biological processes. The molecular mechanisms driving prostate cancer (PCa) bone metastasis (BM) are incompletely understood, and targetable genetic alterations are lacking in the ...
Anne Offermann +20 more
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The role of TRIM family in metabolic associated fatty liver disease
Frontiers in Endocrinology, 2023 Metabolic associated fatty liver disease (MAFLD) ranks among the most prevalent chronic liver conditions globally. At present, the mechanism of MAFLD has not been fully elucidated.
Jingyue Zhang +4 more
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TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Nature Communications, 2020 Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid ...
Alvin Yu +5 more
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TRIM family contribute to tumorigenesis, cancer development, and drug resistance
Experimental Hematology & Oncology, 2022 The tripartite-motif (TRIM) family represents one of the largest classes of putative single protein RING-finger E3 ubiquitin ligases. TRIM family is involved in a variety of cellular signaling transductions and biological processes.
Ning Huang +6 more
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The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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Genome-Wide Identification and Expression Analysis of Potential Antiviral Tripartite Motif Proteins (TRIMs) in Grass Carp (Ctenopharyngodon idella) [PDF]
Biology, 2021 Tripartite motif proteins (TRIMs), especially B30.2 domain-containing TRIMs (TRIMs-B30.2), are increasingly well known for their antiviral immune functions in mammals, while antiviral TRIMs are far from being identified in teleosts. In the present study, we identified a total of 42 CiTRIMs from the genome of grass carp, Ctenopharyngodon idella, an ...
Beibei Qin +5 more
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TRIM 24 (tripartite motif-containing 24) [PDF]
Atlas of Genetics and Cytogenetics in Oncology and Haematology, 2011 Review on TRIM 24 (tripartite motif-containing 24), with data on DNA, on the protein encoded, and where the gene is implicated.
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