Results 21 to 30 of about 19,697 (197)
TRIM proteins in hepatocellular carcinoma
Journal of Biomedical Science, 2022 The tripartite motif (TRIM) protein family is a highly conserved group of E3 ligases with 77 members known in the human, most of which consist of a RING-finger domain, one or two B-box domains, and a coiled-coil domain.
Kan Lu +5 more
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TRIM Proteins and Their Roles in the Influenza Virus Life Cycle
Microorganisms, 2020 The ubiquitin-proteasome system (UPS) has been recognized for regulating fundamental cellular processes, followed by induction of proteasomal degradation of target proteins, and triggers multiple signaling pathways that are crucial for numerous aspects ...
Hye-Ra Lee +3 more
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Cells, 2021 The tripartite motif (TRIM) protein family is attracting increasing interest in oncology. As a protein family based on structure rather than function, a plethora of biological activities are described for TRIM proteins, which are implicated in multiple ...
Eleonora Pauletto +4 more
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Peering into the ‘black box’ of pathogen recognition by cellular autophagy systems
Microbial Cell, 2015 Autophagy is an intracellular process that plays an important role in protecting eukaryotic cells and maintaining intracellular homeostasis. Pathogens, including bacteria and viruses, that enter cells can signal induction of selective autophagy ...
Shu-chin Lai, Rodney J Devenish
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Structural basis for PRYSPRY-mediated tripartite motif (TRIM) protein function [PDF]
Proceedings of the National Academy of Sciences, 2007 The human tripartite motif (TRIM) family comprises 70 members, including HIV restriction factor TRIM5α and disease-associated proteins TRIM20 (pyrin) and TRIM21. TRIM proteins have conserved domain architecture but diverse cellular roles. Here, we describe how the C-terminal PRYSPRY domain mediates diverse TRIM functions.
Leo C, James +4 more
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To TRIM the Immunity: From Innate to Adaptive Immunity
Frontiers in Immunology, 2020 The tripartite motif (TRIM) proteins have been intensively studied as essential modulators in various biological processes, especially in regulating a wide range of signaling pathways involved in immune responses.
Wenyong Yang +3 more
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Cell Proliferation, 2022 AbstractInflammatory bowel disease (IBD) is a chronic recurrent gastrointestinal inflammatory disease that poses a heavy burden to the global healthcare system. However, the current paucity of mechanistic understanding of IBD pathogenesis hampers the development of aetiology‐directed therapies.
Rirong Chen +6 more
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C-terminal processing of GlyGly-CTERM containing proteins by rhombosortase in Vibrio cholerae.
PLoS Pathogens, 2018 Vibrio cholerae and a subset of other Gram-negative bacteria, including Acinetobacter baumannii, express proteins with a C-terminal tripartite domain called GlyGly-CTERM, which consists of a motif rich in glycines and serines, followed by a hydrophobic ...
Shilpa Gadwal +3 more
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The Roles of TRIMs in Antiviral Innate Immune Signaling
Frontiers in Cellular and Infection Microbiology, 2021 The Tripartite motif (TRIM) protein family, which contains over 80 members in human sapiens, is the largest subfamily of the RING-type E3 ubiquitin ligase family.
Zhou Shen +8 more
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Molecular & Cellular Oncology, 2018 Protein misfolding and protein aggregation are linked to several diseases commonly called as proteinopathies, which include cancer. Understanding the mechanisms of proteostasis could provide newer strategies to combat proteinopathies.
Kautilya Kumar Jena +4 more
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