Results 31 to 40 of about 19,697 (197)

Trim24 prompts tumor progression via inducing EMT in renal cell carcinoma

Open Medicine, 2020
Renal cell carcinoma (RCC) is a malignant tumor originating from renal tubular epithelial cells with poor prognosis and high metastatic rate. Tripartite motif-containing 24 (Trim24) is a member of the tripartite motif (Trim) family and also a valuable ...
Jiang Tao, Mao Houping, Chen Qin, Cao Linsheng, He Yanfeng, Gao Xingjian, Chen Wenwei, Zhang Hua   +7 more
doaj   +1 more source

Antiretroviral potential of human tripartite motif-5 and related proteins

Virology, 2006
TRIM5alpha is a potent inhibitor of infection by diverse retroviruses and is encoded by one of a large family of TRIM genes. We found that several TRIM motifs among a panel of selected human TRIM proteins (TRIM1, 5, 6, 18, 19, 21 22, 34) could inhibit infection when artificially targeted to an incoming HIV-1 capsid.
Zhang, Fengwen, Hatziioannou, Theodora, Perez-Caballero, David, Derse, David, Bieniasz, Paul D.   +4 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The ubiquitin ligase tripartite-motif-protein 32 is induced in Duchenne muscular dystrophy [PDF]

Laboratory Investigation, 2016
Activation of the proteasome pathway is one of the secondary processes of cell damage, which ultimately lead to muscle degeneration and necrosis in Duchenne muscular dystrophy (DMD). In mdx mice, the proteasome inhibitor bortezomib up-regulates the membrane expression of members of the dystrophin complex and reduces the inflammatory reaction.
ASSERETO, STEFANIA, Piccirillo, Rosanna, Baratto, Serena, SCUDIERI, PAOLO, FIORILLO, CHIARA, MASSACESI, MANUELA, TRAVERSO, MONICA, GALIETTA, LUIS JUAN VICENTE, BRUNO, CLAUDIO, MINETTI, CARLO, ZARA, FEDERICO, Gazzerro, Elisabetta   +11 more
openaire   +5 more sources

Untersuchungen zur Funktion des tripartite-motif-22 (TRIM22)-Proteins [PDF]

, 2022
TRIM22 is an intracellular protein that has previously been shown to exhibit manifold functions in human cells. TRIM22 is described to have antiviral potential, may function as an ubiquitin E3 ligase and is described to be involved in cellular processes like cell differentiation and cell proliferation.
Deuschl, Cornelius, Gruber, Jens, Georg-August-Universität Göttingen, Walter, Lutz, Bohnsack, Markus   +4 more
openaire   +2 more sources

Analysis of the Zn-Binding Domains of TRIM32, the E3 Ubiquitin Ligase Mutated in Limb Girdle Muscular Dystrophy 2H

Cells, 2019
Members of the tripartite motif family of E3 ubiquitin ligases are characterized by the presence of a conserved N-terminal module composed of a RING domain followed by one or two B-box domains, a coiled-coil and a variable C-terminal region. The RING and
Elisa Lazzari, Medhat S. El-Halawany, Matteo De March, Floriana Valentino, Francesco Cantatore, Chiara Migliore, Silvia Onesti, Germana Meroni   +7 more
doaj   +1 more source

Cancer cell‐intrinsic type 1 interferon: production, signaling, and outcomes within sex‐biased, female malignancies

Molecular Oncology, EarlyView.
The cell‐autonomous roles of interferon type 1 vary based on duration and intensity. While acute, robust signaling results in cancer cell cytotoxic effects, sustained, low‐level signaling is associated with tumor‐promoting effects. This review summarizes current research of IFN‐1 in cancer and within the clinical setting, with an emphasis on female ...
Ashlyn Conant, Nora Badiner, Sharon Asariah, Kiera McGivney, Vishwa Shah, Tise Suzuki, Yevgeniya J. Ioffe, Juli J. Unternaehrer   +7 more
wiley   +1 more source

Identification and characterization of multiple TRIM proteins that inhibit hepatitis B virus transcription. [PDF]

PLoS ONE, 2013
Tripartite motif (TRIM) proteins constitute a family of over 100 members that share conserved tripartite motifs and exhibit diverse biological functions. Several TRIM proteins have been shown to restrict viral infections and regulate host cellular innate
Shijian Zhang, Ju-Tao Guo, Jim Z Wu, Guang Yang   +3 more
doaj   +1 more source

TRIM18-Regulated STAT3 Signaling Pathway via PTP1B Promotes Renal Epithelial–Mesenchymal Transition, Inflammation, and Fibrosis in Diabetic Kidney Disease

Frontiers in Physiology, 2021
Diabetic kidney disease (DKD) has become a key cause of end-stage renal disease worldwide. Inflammation and fibrosis have been shown to play important roles in the pathogenesis of DKD.
Qi Chen, Chan Gao, Ming Wang, Xiao Fei, Ning Zhao   +4 more
doaj   +1 more source

A Conserved DT2‐bZIP66‐NF‐YC4 Regulatory Module Confers Drought Tolerance in Rice and Arabidopsis

Advanced Science, EarlyView.
This study identifies a conserved tripartiteDT2–bZIP66–NF‐YC4 transcriptional module that enhances rice drought tolerance by activating stress‐responsive genes. This regulatory complex is functionally conserved across cereals and Arabidopsis, providing promising targets for engineering drought‐resilient crops. ABSTRACT Drought stress severely restricts
Jun Shen, Yuchen Li, Liang Zhang, Xiaosong Ma, Chenyin Peng, Chunting Yuan, Yu Wu, Kaiyu Zhao, Sheng Zhao, Jiazhuo Guo, Run Li, Ziqian Yan, Shule Ren, Yige Han, Xin Lin, Xinyue Li, Ming Li, Pingfang Yang, Shiyong Song   +18 more
wiley   +1 more source