Results 11 to 20 of about 19,697 (197)
Control of Viral Infectivity by Tripartite Motif Proteins [PDF]
Human Gene Therapy, 2005 It is of great interest to understand the molecular details of the pathways that constitute species barriers to viral infection. The tripartite motif protein TRIM5alpha has emerged as an important mediator of species-specific retroviral replication and innate immunity. This review considers the role of TRIM5alpha as an antiviral protein in mammals. The
Gregory Towers
exaly +5 more sources
The control of viral infection by tripartite motif proteins and cyclophilin A [PDF]
Retrovirology, 2007 The control of retroviral infection by antiviral factors referred to as restriction factors has become an exciting area in infectious disease research.
Towers Greg J
doaj +4 more sources
Emerging roles of tripartite motif family proteins (TRIMs) in breast cancer
Cancer MedicineBreast cancer (BC) is the most common malignant tumor worldwide. Despite enormous progress made in the past decades, the underlying mechanisms of BC remain further illustrated. Recently, TRIM family proteins proved to be engaged in BC progression through
Jianing Cao +4 more
doaj +3 more sources
Tripartite motif proteins: an emerging antiviral protein family. [PDF]
Future Virol, 2019 Patil G, Li S.
europepmc +4 more sources
InTRIMsic immunity: Positive and negative regulation of immune signaling by tripartite motif proteins. [PDF]
Cytokine Growth Factor Rev, 2014 During the immune response, striking the right balance between positive and negative regulation is critical to effectively mount an anti-microbial defense while preventing detrimental effects from exacerbated immune activation. Intra-cellular immune signaling is tightly regulated by various post-translational modifications, which allow for this dynamic
Versteeg GA +3 more
europepmc +4 more sources
TRIM32 and Malin in Neurological and Neuromuscular Rare Diseases
Cells, 2021 Tripartite motif (TRIM) proteins are RING E3 ubiquitin ligases defined by a shared domain structure. Several of them are implicated in rare genetic diseases, and mutations in TRIM32 and TRIM-like malin are associated with Limb-Girdle Muscular Dystrophy ...
Lorena Kumarasinghe +5 more
doaj +1 more source
TRIM5α self-assembly and compartmentalization of the HIV-1 viral capsid
Nature Communications, 2020 Tripartite-motif containing (TRIM) proteins modulate cellular responses to viral infection. Here the authors use molecular dynamics simulations to demonstrate that TRIM5α uses a two-dimensional lattice hopping mechanism to aggregate on the HIV capsid ...
Alvin Yu +5 more
doaj +1 more source
Autophagy Reports, 2023 Mycobacterium tuberculosis (Mtb) promotes its intracellular persistence by subverting defense mechanisms, such as autophagy. Remarkably, enhancing autophagy is sufficient to trigger intracellular Mtb killing and effective immune response, making this ...
Alessandra Romagnoli +3 more
doaj +1 more source
Human TRIM gene expression in response to interferons. [PDF]
PLoS ONE, 2009 BackgroundTripartite motif (TRIM) proteins constitute a family of proteins that share a conserved tripartite architecture. The recent discovery of the anti-HIV activity of TRIM5alpha in primate cells has stimulated much interest in the potential role of ...
Laetitia Carthagena +10 more
doaj +1 more source
Role of the Tripartite Motif Protein 27 in Cancer Development [PDF]
JNCI: Journal of the National Cancer Institute, 2012 The tripartite motif family protein 27 (TRIM27) is a transcriptional repressor that interacts with, and attenuates senescence induction by, the retinoblastoma-associated protein (RB1). High expression of TRIM27 was noted in several human cancer types including breast and endometrial cancer, where elevated TRIM27 expression predicts poor prognosis. Here,
Zoumpoulidou, G +5 more
openaire +3 more sources