Publisher Correction: Structure and activation of the RING E3 ubiquitin ligase TRIM72 on the membrane. [PDF]
Nat Struct Mol BiolPark SH +11 more
europepmc +2 more sources
Protective role of MG53 against ischemia/reperfusion injury on multiple organs: A narrative review
Frontiers in Physiology, 2022 Ischemia/reperfusion (I/R) injury is a common clinical problem after coronary angioplasty, cardiopulmonary resuscitation, and organ transplantation, which can lead to cell damage and death.
Bowen Xu +9 more
doaj +1 more source
Post-Injury Administration of Recombinant TRIM72 Protein Ameliorates Bleomycin-Induced Pulmonary Fibrosis [PDF]
B64. MECHANISTIC ADVANCES IN LUNG FIBROSIS, 2020 X. Cong, N. Nagre, X. Zhao
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Cardiac effects and clinical applications of MG53
Cell & Bioscience, 2021 Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention.
Weina Zhong +4 more
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Redox Biology, 2022 Ischemic injury to the heart induces mitochondrial dysfunction due to increasing oxidative stress. MG53, also known as TRIM72, is highly expressed in striated muscle, is secreted as a myokine after exercise, and is essential for repairing damaged plasma ...
Kristyn Gumpper-Fedus +13 more
doaj +1 more source
The C2A domain in dysferlin is important for association with MG53 (TRIM72)
PLoS Currents, 2012 In skeletal muscle, Mitsugumin 53 (MG53), also known as muscle-specific tripartite motif 72, reportedly interacts with dysferlin to regulate membrane repair. To better understand the interactions between dysferlin and MG53, we conducted immunoprecipitation (IP) and pull-down assays.
Matsuda, Chie +8 more
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TRIM72 modulates caveolar endocytosis in repair of lung cells
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2016 Alveolar epithelial and endothelial cell injury is a major feature of the acute respiratory distress syndrome, in particular when in conjunction with ventilation therapies. Previously we showed [Kim SC, Kellett T, Wang S, Nishi M, Nagre N, Zhou B, Flodby P, Shilo K, Ghadiali SN, Takeshima H, Hubmayr RD, Zhao X.
Nagaraja, Nagre +12 more
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The E3 ubiquitin ligase MG53 inhibits hepatocellular carcinoma by targeting RAC1 signaling
Oncogenesis, 2022 Ras-related C3 botulinum toxin substrate 1 (RAC1) overexpressiosn and hyperactivation are correlated with aggressive growth and other malignant characteristics in a wide variety of cancers including hepatocellular carcinoma (HCC). However, the regulatory
Xiaomin Ma +9 more
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Loading-associated expression of TRIM72 and caveolin-3 in antigravitational soleus muscle in mice [PDF]
Physiological Reports, 2014 Effects of mechanical loading on the expression level of tripartite motif-containing 72 (TRIM72) and caveolin-3 (Cav-3) in mouse soleus muscle were investigated. Mice were subjected to (1) continuous hindlimb suspension (HS) for 2 weeks followed by 1-week ambulation recovery or (2) functional overloading (FO) on the soleus by cutting the distal tendons
Ohno, Yoshitaka +4 more
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Anti-TRIM72 Autoantibodies in Idiopathic Inflammatory Myopathies
The Journal of RheumatologyAbstract Background and Purpose Tripartite motif-containing protein 72 (TRIM72) mediates tissue-repair following injury in several organs, including muscle and lung. Autoantibodies directed against TRIM72 (anti-TRIM72) have been identified in patients with idiopathic inflammatory myopathies (IIM) and
Krustev, Eugene +12 more
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