Results 61 to 70 of about 868 (158)

Modulation of TRIM72 Alters the Repair Capacity of Lung Epithelial Cells

Annals of the American Thoracic Society, 2015
The molecular mechanisms for alveolar epithelial cell plasma membrane wounding and repair are largely unknown. Previous studies identified TRIM72 (also known as mitsugumin 53) from striated muscle tissues and linked its physiological functions in these tissues to membrane repair, cell proliferation, and glucose metabolism.
Seong Chul Kim, Thomas Kellett, Shaohua Wang, Miyuki Nishi, Nagaraja Nagre, Beiyun Zhou, Per Flodby, Konstantin Shilo, Samir N. Ghadiali, Hiroshi Takeshima, Rolf D. Hubmayr, Xiaoli Zhao   +11 more
openaire   +2 more sources

Oncogenic KRAS Rewires Stress Granule Dynamics: Mechanisms and Therapeutic Opportunities

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Stress granules (SGs) are dynamic, membrane‐less structures that form in response to various cellular stresses, including metabolic, oxidative, and therapeutic challenges. They function as adaptive hubs and reorganize protein synthesis and signaling networks to help cells survive under stress. In cancer, these condensates are often hijacked to
Msimisi Ndzinisa, Birhanetensay Masresha Altaye, Yuh‐Pyng Sher   +2 more
wiley   +1 more source

Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53 [PDF]

, 2021
As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon energy and glucose shortage but suppressed upon overnutrition.
Yang, D, Lejiao Ren, Lv, F, Quan, L, Xiuqin Zhang, Ren, L, Xiaoyu Bai, Fengli Xu, Xu, F, Fengxiang Lv, Zhong Yu, Rui-Ping Xiao, Peng, W, Bai, X, Dan Yang, Li Zhi, Wang, X, Wei Peng, Zhi, L, Jiang, P, Kunlun Cheng, Zhang, Y, Zhang, X, Xianhua Wang, Cheng, K, Yu, Z, Yan Zhang, Li Quan, Hu, X, Peng Jiang, Xiao, RP, Xinli Hu   +31 more
core   +1 more source

TRIM Expression and Its Association With Disease Activity in Systemic Lupus Erythematosus

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with diverse manifestations, including rash, arthritis, and nephritis. Although autoantibodies are a key feature of SLE, their levels often poorly reflect disease severity, suggesting the involvement of additional contributing factors.
Ling‐Ying Lu, Ling‐Jung Yen, Hui‐Ling Hsia, Zi‐Xeng Weng, Chi‐Hsiang Chung, Paul Wei‐Che Hsu, Chih‐Wei Chiu, Wu‐Chien Chien, Tsung‐Hsien Chang   +8 more
wiley   +1 more source

TRIM72 negatively regulates the IFN system. [PDF]

(A-E) Empty vector or TRIM72-flag over-expression vectors were transfected into N2a cells respectively for 12 h, then infected with RABV (MOI = 1) for 48 h, and the mRNA levels of IFN-β (A), Isg15 (B), Ifit1 (C) Ifit2 (D) and Ifit3 (E) were analyzed by ...
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

ARH1 in Health and Disease [PDF]

, 2020
Arginine-specific mono-adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD)+-dependent, reversible post-translational modification involving the transfer of an ADP-ribose from NAD+ by bacterial toxins and eukaryotic ADP ...
Hiroko Ishiwata-Endo, Joel Moss, Linda A. Stevens, Jiro Kato   +3 more
core   +1 more source

ARH Family of ADP-Ribose-Acceptor Hydrolases

Cells, 2022
The ARH family of ADP-ribose-acceptor hydrolases consists of three 39-kDa members (ARH1-3), with similarities in amino acid sequence. ARH1 was identified based on its ability to cleave ADP-ribosyl-arginine synthesized by cholera toxin.
Hiroko Ishiwata-Endo, Jiro Kato, Sachiko Yamashita, Chanbora Chea, Kazushige Koike, Duck-Yeon Lee, Joel Moss   +6 more
doaj   +1 more source

Proteomic Profiling of Myofiber Repair Annexins and Their Role in Duchenne Muscular Dystrophy

PROTEOMICS, EarlyView.
ABSTRACT Myofiber regeneration and membrane repair play crucial roles in maintaining the continuous physiological functioning of the neuromuscular system. A swift and efficient repair mechanism enables the rapid restoration of sarcolemmal integrity following cellular impairment in damaged skeletal muscles.
Paul Dowling, Dounia Bouragba, Elisa Negroni, Capucine Trollet, Margit Zweyer, Dieter Swandulla, Kay Ohlendieck   +6 more
wiley   +1 more source

TRIM72 attenuates RABV pathogenicity in vivo. [PDF]

(A-C) Female C57 BL/6 mice (8-week-old, n = 10) were intranasally infected with 100 FFU rRABV, rRABV-Trim72, rRABV-Trim72(-), or were mock-infected. Body weight change (A), clinical score (B), and survival ratio (C) were monitored daily for continuous 3 ...
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

The Effects of Antioxidants and Pulsed Magnetic Fields on Slow and Fast Skeletal Muscle Atrophy Induced by Streptozotocin: A Preclinical Study

Journal of Diabetes Research, 2023
Background and Objectives. Skeletal muscle atrophy, a condition characterized by decreased muscle mass and contractility, is commonly observed in various pathological states, including prolonged inactivity, malnutrition, sarcopenia, and type 1 diabetes ...
Bora Tastekin, Aykut Pelit, Tugce Sapmaz, Alper Celenk, Muhammed Majeed, Lakshmi Mundkur, Kalyanam Nagabhushanam   +6 more
doaj   +1 more source