Results 81 to 90 of about 868 (158)

CRISPR Enabled Precision Oncology: From Gene Editing to Tumor Microenvironment Remodeling

Med Research, Volume 2, Issue 1, Page 106-129, March 2026.
CRISPR technology has progressed from a prokaryotic immune system to a diverse suite of editing platforms, including Cas nucleases, base and prime editors, and RNA‐targeting enzymes. These advances enable precise genomic and epigenomic interventions, high‐throughput functional screening, and immune engineering.
Kailai Li, Peixin Huang, Yue Qian, Anqi Lin, Jingjun He, Junyi Shen, Li Chen, Kai Miao, Jian Zhang   +8 more
wiley   +1 more source

Protein Array-Based Approach to Evaluate Biomarkers of Beef Tenderness and Marbling in Cows: Understanding of the Underlying Mechanisms and Prediction

Foods, 2020
This study evaluated the potential of a panel of 20 protein biomarkers, quantified by Reverse Phase Protein Array (RPPA), to explain and predict two important meat quality traits, these being beef tenderness assessed by Warner–Bratzler shear force (WBSF)
Mohammed Gagaoua, Muriel Bonnet, Brigitte Picard   +2 more
doaj   +1 more source

Inhaled TRIM72 Protein Protects Ventilation Injury to the Lung through Injury-guided Cell Repair [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2018
Abstract Studies showed that TRIM72 is essential for repair of alveolar cell membrane disruptions, and exogenous recombinant human TRIM72 protein (rhT72) demonstrated tissue-mending properties in animal models of tissue injury. Here we examine the mechanisms of rhT72-mediated lung cell protection in vitro and test the efficacy of ...
Nagaraja, Nagre, Xiaofei, Cong, Hong-Long, Ji, John M, Schreiber, Hongyun, Fu, Ian, Pepper, Seth, Warren, Joshua M, Sill, Rolf D, Hubmayr, Xiaoli, Zhao   +9 more
openaire   +2 more sources

A Brain‐Targeting Curcumin Analog Inhibits Glioblastoma Progression Through THBS1/TGF‐β1/PI3K–AKT Axis Modulation: Evidence From Experimental and Bioinformatic Analyses

Journal of Cellular and Molecular Medicine, Volume 30, Issue 5, March 2026.
ABSTRACT Glioblastoma (GBM) is the most aggressive primary brain tumour, associated with a dismal prognosis and an urgent need for innovative therapeutic strategies. To address this challenge, our group developed DMC‐GF, a novel brain‐targeted curcumin analog engineered to enhance blood–brain barrier permeability by blocking metabolic sites and ...
Zijian Han, Xuetao Li, Yang Zhu, Zhimin Wang, Yingbo Hou, Huiling Tao, Meng Ma, Xiangtong Xie, HaiYang Zhang   +8 more
wiley   +1 more source

TRIM72 induces ubiquitination of RABV-M at K195. [PDF]

(A) Illustration of the lysine (K) sites in RABV-M. (B) The lysine residues in RABV-M were mutated to alanine and over-expression vectors were constructed and together with pCAGGS or pCA-Trim72-flag were co-transfected into N2a cells respectively for 48 ...
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

The Roles of Tripartite Motif-containing Protein 72 in Oral Cancer Progression [PDF]

, 2017
目的:我們的目標在於探討三分膜體包含蛋白72號在口腔鱗狀上皮細胞癌進程中所扮演的角色，並將其與臨床上的資料以及病人的存活率藉由統計方式比較其相關性。除此之外，也針對其詳細的調控機轉作進一步的探究及闡述。 實驗設計:利用SAS、CA922、HSC3、Cal27以及TW2.6五株口腔鱗狀上皮細胞癌細胞株來探討三分膜體包含蛋白72號表現量被小髮夾型核糖核酸抑制或轉殖表現質體過度表現後的移行能力、浸襲能力以及生長能力是否有受到影響。在細胞移動能力的測定上，我們利用博登細胞移行器實驗來做分析 ...
周傳鈞, Chou, Chuan-Chun
core   +1 more source

Ventilator‐Induced Lung Injury: Mechanotransduction and Potential Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Mechanical ventilation (MV) is expected to undergo significant transformative advancements by 2050, with the emergence of personalized ventilation systems that promise to revolutionize respiratory care. However, the risk of ventilator‐induced lung injury (VILI) remains a significant concern at this stage and VILI still exists at that time.
He Ren, Ziqi Shang, Alastair G. Stewart, Ying‐xin Qi, Kai Huang   +4 more
wiley   +1 more source

Enhancing membrane repair increases regeneration in a sciatic injury model.

PLoS ONE, 2020
Various injuries to the neural tissues can cause irreversible damage to multiple functions of the nervous system ranging from motor control to cognitive function.
Brian J Paleo, Kathryn M Madalena, Rohan Mital, Kevin E McElhanon, Thomas A Kwiatkowski, Aubrey L Rose, Jessica K Lerch, Noah Weisleder   +7 more
doaj   +1 more source

Newly Identified Transcriptomic Biomarkers and Gene Signature of Pathological Complete Response to Induction Chemoimmunotherapy in Locally Advanced Head and Neck Squamous Cell Carcinoma

MedComm, Volume 7, Issue 1, January 2026.
Scheme and pathological characteristics of the CheckRad‐CD8 trial cohort used for the transcriptome analyses. (A) Flow diagram depicting the patient cohort and study scheme as the basis for whole transcriptome profiling of samples from locally advanced HNSCC patients treated with induction chemoimmunotherapy (iCIT).
Jian‐Guo Zhou, Markus Eckstein, Haitao Wang, Tianjun Lan, Benjamin Frey, Xin Li, Xiaofan Lu, Gunther Klautke, Thomas Illmer, Maximilian Fleischmann, Simon Laban, Matthias G. Hautmann, Bálint Tamaskovics, Thomas B. Brunner, Arndt Hartmann, Rainer Fietkau, Hu Ma, Antoniu‐Oreste Gostian, Heinrich Iro, Markus Hecht, Udo S. Gaipl   +20 more
wiley   +1 more source

TRIM72 interacts with LBV-M and MOKV-M. [PDF]

(A-B) HA-tagged lyssavirus M proteins (LBV-M-HA and MOKV-MHA) together with empty vector or TRIM72-flag were co-overexpressed in N2a cells respectively. Co-IP assays were performed with anti-flag antibody post-transfection for 48 h and protein levels of ...
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source