Results 71 to 80 of about 868 (158)

Ubiquitin and ubiquitin‐like modifications in the endoplasmic reticulum stress response

The FEBS Journal, EarlyView.
Endoplasmic reticulum (ER) stress activates various proteostasis control processes, including the unfolded protein response, ribosome‐associated quality control, and ER‐associated degradation. Ubiquitin and ubiquitin‐like modifications dynamically regulate these processes to determine cell fate, promoting adaptation or inducing cell death.
Tony Avril, Matthieu Le Gallo, Elodie Lafont   +2 more
wiley   +1 more source

TRIM72 restricts RABV infection at the viral release stage. [PDF]

(A) TRIM72-flag over-expression vector or empty vector were transfected into N2a cells respectively for 36 h, then infected with RABV (MOI = 0.1) for 1 h at 4°C, the cells were collected and the viral genomic RNA (vRNA) levels were analyzed by qPCR.
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, Volume 13, Issue 37, 3 July 2026.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

Stem Cell and Drug Delivery Systems for Promoting Angiogenesis and Myogenesis in Ischemic Limbs [PDF]

, 2023
Peripheral artery disease (PAD) is a widespread atherosclerotic disorder affecting more than 200 million people globally, with critical limb ischemia (CLI) being its most severe manifestation. Stem cell therapy has been a promising CLI treatment, but the
Gao, Ning
core   +2 more sources

Serum MG53/TRIM72 Is Associated With the Presence and Severity of Coronary Artery Disease and Acute Myocardial Infarction

Frontiers in Physiology, 2020
Background: Mitsugumin 53 or Tripartite motif 72 (MG53/TRIM72), a myokine/cardiokine belonging to the tripartite motif family, can protect the heart from ischemic injury and regulate lipid metabolism in rodents. However, its biological function in humans
Hongyang Xie, Hongyang Xie, Yaqiong Wang, Tianqi Zhu, Shuo Feng, Zijun Yan, Zhengbin Zhu, Jingwei Ni, Jun Ni, Run Du, Jinzhou Zhu, Fenghua Ding, Shengjun Liu, Hui Han, Hang Zhang, Jiaxin Zhao, Ruiyan Zhang, Weiwei Quan, Xiaoxiang Yan, Xiaoxiang Yan   +19 more
doaj   +1 more source

Age‐Dependent Remodeling of the Sciatic Nerve Proteome in 5xFAD Mice Can Be Attenuated by Exercise or Donepezil Treatment to Maintain Neuromuscular Function

Aging Cell, Volume 25, Issue 6, June 2026.
Sciatic nerve proteome remodeling, particularly of mitochondrial‐centric pathways, occurs at 4 months of age in 5xFAD mice, coinciding with onset of neuromuscular dysfunction. Exercise or the acetylcholinesterase inhibitor donepezil, begun prior to onset, delays these phenotypes, suggesting early peripheral phenotypes of Alzheimer's Disease may have ...
Matthew H. Brisendine, Dijanira Q. Nieves‐Esparcia, Orion S. Willoughby, Brieann Brown, John R. Brown, Daniel S. Braxton, Shelby N. Henry, Colin S. McCoin, John P. Thyfault, Jill K. Morris, Steven Poelzing, Robert W. Grange, Timothy J. Jarome, Charles P. Najt, Joshua C. Drake   +14 more
wiley   +1 more source

Selected proteins from 2-DE were confirmed by immunoblot analysis. [PDF]

, 2013
Expression of Trim72, Myh4, Skeletal Muscle Actin (SM Actin), Hsp25 and Fabp4 were assessed by western blot analysis of skeletal muscle proteins from NC, HC, and HE mice; β-tubulin was used as an internal control for loading.
Yanmei Niu (104136), Wenyan Niu (104150), Xiaolei Liu (104141), Li Fu (85791), Hairui Yuan (104130), Fengying Yang (104146)   +5 more
core   +1 more source

MG53 suppresses tumor progression and stress granule formation by modulating G3BP2 activity in non-small cell lung cancer

Molecular Cancer, 2021
Background Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2.
Haichang Li, Pei-Hui Lin, Pranav Gupta, Xiangguang Li, Serena Li Zhao, Xinyu Zhou, Zhongguang Li, Shengcai Wei, Li Xu, Renzhi Han, Jing Lu, Tao Tan, Dong-Hua Yang, Zhe-Sheng Chen, Timothy M. Pawlik, Robert E. Merritt, Jianjie Ma   +16 more
doaj   +1 more source

TRIM72 induces proteasomal degradation of RABV-M by promoting K48-linked ubiquitination. [PDF]

(A) pCAGGS or pCA-Trim72-myc together with pCA-N, pCA-P, pCA-M-HA, and pCA-G-flag were co-transfected into N2a cells respectively for 48 h, and the protein levels of N, P, M-HA and G-flag were analyzed by western blotting.
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

A Novel Dysferlin‐Binding Kinase CK2α Promotes Plasma Membrane Repair in Dysferlinopathy

The FASEB Journal, Volume 40, Issue 6, 31 March 2026.
When the cell membrane is injured, extracellular calcium enters the cell, triggering the accumulation of dysferlin at the lesion site. In the presence of dysferlin, CK2 is efficiently recruited to the damaged membrane and maintains its kinase activity through interaction with dysferlin.
Naoko Nakamura, Naoki Suzuki, Shin‐ichiro Kanno, Rei Yamanaka, Hiroya Ono, Rumiko Izumi, Rui Muliang, Christian Borgo, Akiyuki Ohno, Ryuhei Harada, Saki Saito, Yukino Funayama, Kensuke Ikeda, Shio Mitsuzawa, Yasuaki Watanabe, Tomomi Shijo, Tetsuya Akiyama, Toshiaki Takahashi, Makoto Kanzaki, Shion Osana, Hitoshi Warita, Yoshitsugu Aoki, Satoru Ebihara, Mauro Salvi, Ryoichi Nagatomi, Akira Yasui, Katsuya Miyake, Masashi Aoki   +27 more
wiley   +1 more source