Development of an Individualized Ubiquitin Prognostic Signature for Clear Cell Renal Cell Carcinoma
Frontiers in Cell and Developmental Biology, 2021 Clear cell renal cell carcinoma (ccRCC) is a common tumor type in genitourinary system and has a poor prognosis. Ubiquitin dependent modification systems have been reported in a variety of malignancies and have influenced tumor genesis and progression ...
Yue Wu +23 more
doaj +1 more source
Impacts of TRIM72 on bleomycin-induced injury and pulmonary fibrosis; an in-vitro approach. [PDF]
, 2022 Idiopathic Pulmonary Fibrosis is a chronic, progressive disease of the lungs where thick scar tissue develops irreversibly, leading to dyspnea and respiratory failure.
Rathi, Rohan
core
RABV infection induces TRIM72 and TRIM72 reduces RABV replication. [PDF]
(A-B) SK-N-SH cells were infected with RABV at different MOI for 36 h. The mRNA level of TRIM72 was analyzed by qPCR (A), and the protein levels of TRIM72 and RABV-N were analyzed by western blotting (B).
Ling Zhao (111365) +4 more
core +1 more source
Molecular Biology and Evolution, 2021 Abstract Cis-regulatory elements play important roles in tissue-specific gene expression and in the evolution of various phenotypes, and mutations in promoters and enhancers may be responsible for adaptations of species to environments. TRIM72 is a highly conserved protein that is involved in energy metabolism.
Yuanqing Feng +14 more
openaire +2 more sources
Comprehensive Analysis of the Prognostic Values of the TRIM Family in Hepatocellular Carcinoma
Frontiers in Oncology, 2021 BackgroundAccumulating studies have demonstrated the abnormal expressions and prognostic values of certain members of the tripartite motif (TRIM) family in diverse cancers.
Weiyu Dai +19 more
doaj +1 more source
S-nitrosylation of TRIM72 mends the broken heart: A molecular modifier-mediated cardioprotection [PDF]
Journal of Molecular and Cellular Cardiology, 2014 Cardiovascular diseases (CVDs) are a leading cause of death globally, casting substantial economic and societal burdens. This devastating situation imposes a pressing need to identify novel cardioprotective mechanisms that will reinforce and innovate the current medical interventions for CVDs [1–3].
C Y, X'avia Chan +4 more
openaire +2 more sources
TRIM72 induces the degradation of M. [PDF]
(A) pCAGGS or pCA-hTrim72-flag together with pCA-M-HA were co-transfected into SK-N-SH cells respectively for 48 h, and the protein levels of M-HA and hTRIM72-flag were analyzed by western blotting.
Ling Zhao (111365) +4 more
core +1 more source
TRIM72 Immunohistochemical Expression Can Predict Relapse in Colorectal Carcinoma
Pathology & Oncology Research, 2019 Large bowel adenocarcinoma is one of the most frequent human neoplasms and despite recent insights into the pathophysiology and molecular basis of this disease, mortality remains high in advanced and metastatic cases. Most guidelines recommend adjuvant chemotherapy for tumours involving lymph nodes, but not for patients with localized stage I or II ...
M. J. Fernández-Aceñero +7 more
openaire +2 more sources
TRIM72 directly interacts with RABV-M via the SPRY domain. [PDF]
(A) pCAGGS or pCA-Trim72-flag together with pCA-M-HA were co-transfected into N2a cells respectively. Then Mg132 (10 μM) was treated, and Co-IP assays were performed with anti-flag antibody post-transfection for 48 h.
Ling Zhao (111365) +4 more
core +1 more source
RABV infection induces up-regulation of TRIM72 in mouse brains and neuronal cells, and TRIM72 reduced RABV replication in neuronal cells. [PDF]
(A-B) 8-week-old female C57 BL/6 mice were intranasally infected with 100 fluorescence focus units (FFU) RABV (CVS-B2c) or mock-infected. The mouse brains were collected at 12th d post-infection, the mRNA level of TRIM72 was analyzed by qPCR (A), and the
Ling Zhao (111365) +4 more
core +1 more source