Results 31 to 40 of about 868 (158)

TRIM72 is required for effective repair of alveolar epithelial cell wounding

American Journal of Physiology - Lung Cellular and Molecular Physiology, 2014
The molecular mechanisms for lung cell repair are largely unknown. Previous studies identified tripartite motif protein 72 (TRIM72) from striated muscle and linked its function to tissue repair. In this study, we characterized TRIM72 expression in lung tissues and investigated the role of TRIM72 in repair of alveolar epithelial cells. In vivo injury of
Per Flodby, K Shilo, Samir Ghadiali
exaly   +4 more sources

MG53 in Early Skeletal Muscle Stem Cell Activation: Implications for Aged Muscle Regeneration [PDF]

Cells
Skeletal muscle regeneration declines with age despite the persistence of satellite cells (muscle stem cells, MuSCs), suggesting that regenerative impairment reflects functional dysregulation rather than MuSC depletion.
Yanping Xu, Jethro Wang Zih-Shuo, Zhentao Zhang, Peng Chen, Usman Alizai, Keerthika Sathish, Sakai Lilian, Zhiyu Yan, Bryan A. Whitson, Timothy M. Pawlik, Hua Zhu   +10 more
doaj   +2 more sources

LINC01852 inhibits the tumorigenesis and chemoresistance in colorectal cancer by suppressing SRSF5-mediated alternative splicing of PKM [PDF]

Molecular Cancer
Background Colorectal cancer (CRC) is a major cause of cancer-related deaths worldwide, and chemoresistance is a major obstacle in its treatment.
Zehua Bian, Fan Yang, Peiwen Xu, Ge Gao, Chunyu Yang, Yulin Cao, Surui Yao, Xue Wang, Yuan Yin, Bojian Fei, Zhaohui Huang   +10 more
doaj   +2 more sources

MG53, a Regenerative Myokine Linking Skeletal Muscle to Cardiac Repair [PDF]

Biomolecules
Mitsugumin 53 (MG53, also TRIM72) is a muscle-enriched tripartite motif protein with a well-established role in acute membrane repair and cytoprotection in striated muscle and other stressed tissues. MG53 is a core component of cellular repair machinery,
Yuchen Chen, Kyung Eun Lee, Jongsoo Kim, Jae-Kyun Ko, Ki Ho Park   +4 more
doaj   +2 more sources

Inhibition of Macrophage Complement Receptor CRIg by TRIM72 Polarizes Innate Immunity of the Lung [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2018
Abstract The complement system plays a critical role in immune responses against pathogens. However, its identity and regulation in the lung are not fully understood. This study aimed to explore the role of tripartite motif protein (TRIM) 72 in regulating complement receptor (CR) of the Ig superfamily (CRIg) in alveolar macrophage (AM)
Nagaraja, Nagre, Xiaofei, Cong, César, Terrazas, Ian, Pepper, John M, Schreiber, Hongyun, Fu, Joshua M, Sill, John W, Christman, Abhay R, Satoskar, Xiaoli, Zhao   +9 more
openaire   +4 more sources

Pathogenic mechanisms of disease in idiopathic inflammatory myopathies: autoantibodies as clues [PDF]

Frontiers in Immunology
Idiopathic inflammatory myopathies (IIMs) encompass a spectrum of autoimmune diseases characterized by muscle inflammation and systemic involvement. This review aimed to synthesize current evidence on the clinical significance and pathogenic mechanisms ...
Yuanhui Wu, Yuanhui Wu, Yuanhui Wu, Jiao Luo, Jiao Luo, Jiao Luo, Lihua Duan, Lihua Duan, Lihua Duan   +8 more
doaj   +2 more sources

Curculigoside Attenuates Endoplasmic Reticulum Stress-Induced Epithelial Cell and Fibroblast Senescence by Regulating the SIRT1-P300 Signaling Pathway [PDF]

Antioxidants
The senescence of alveolar epithelial cells (AECs) and fibroblasts plays a pivotal role in the pathogenesis of idiopathic pulmonary fibrosis (IPF), a condition lacking specific therapeutic interventions.
Weixi Xie, Lang Deng, Rui Qian, Xiaoting Huang, Wei Liu, Siyuan Tang   +5 more
doaj   +2 more sources

MG53 mediates skeletal muscle-liver cross-talk and enhances alcohol metabolism in alcoholic liver disease [PDF]

Nature Communications
Alcoholic liver disease (ALD) remains a significant clinical challenge with limited therapeutics. It is strongly associated with sarcopenia, which further worsens the prognosis in liver cirrhosis. Zinc-deficiency is a hallmark of ALD, impairing the liver’
Tingting Shu, Xindi Zeng, Jing Wang, Haijing Jiang, Yuting Wang, Mingming Zhang, Lintao Jiang, Bo He, Lingzhi Yang, Ning Liu, Ming Tang, Yuanyang Jiang, Linfei Zhang, Ping Chen, Jun Xie, Dandong Fang, Kyung Eun Lee, Yuchen Chen, Jongsoo Kim, Rongning Liu, Yujia Ye, Yu Han, Jianjie Ma, Chunyu Zeng   +23 more
doaj   +2 more sources

Serum Levels of TRIM72 Are Lower among Patients with Colon Cancer: Identification of a Potential Diagnostic Marker

Tohoku Journal of Experimental Medicine, 2018
Colon cancer is one of the most common malignancies causing the majority of cancer-related deaths worldwide. The tripartite motif family protein 72 (TRIM72), also known as mitsugumin 53, acts as an E3 ubiquitin ligase. TRIM72 is involved in insulin resistance and metabolic syndrome, which are risk factors of colon cancer.
Yurong Qiu, Shuyu Chen, Xiaofeng Yin
exaly   +4 more sources

Tripartite motif 72 inhibits apoptosis and mitochondrial dysfunction in neural stem cells induced by anesthetic sevoflurane by activating PI3K/AKT pathway

Chinese Journal of Physiology, 2023
Anesthetics exposure induces neurocognitive deficits during brain development and impairs self-renewal and differentiation of neural stem cells (NSCs).
Minmin Cai, Xiang Gao, Shenghui Yu
doaj   +1 more source