Results 91 to 100 of about 868 (158)

XBP1s‐Orchestrated Soluble Mediators: Participants of Oxidative Stress in Renal Ischemia‐Reperfusion Injury Following Donation After Circulatory Death

Mediators of Inflammation, Volume 2026, Issue 1, 2026.
Ischemia‐reperfusion injury (IRI) presents an intractable challenge for kidney donors, especially in the era of donation after circulatory death (DCD). Based on in‐depth studies of the renal IRI phenomenon, and the mechanisms involved, an increasing number of soluble mediators are being frequently associated with cellular dysfunction, cell death, and ...
Ji Zhang, Yuanyuan Zhao, Jinbiao Zhong, Handong Ding, Wei Chen, Dongsheng Li, Xianguo Chen, Daofang Zhu, Guiyi Liao, Nianqiao Gong, Jasbir Arora (Rss)   +10 more
wiley   +1 more source

K195 is the conserved ubiquitination site among lyssavirus targeted by TRIM72. [PDF]

(A-D) HA-tagged lyssavirus M proteins (DRV-M-HA, ABLV-M-HA, DUVV-M-HA and EBLV-M-HA) together with empty vector or TRIM72-flag were co-overexpressed in N2a cells for 48 h, then protein levels of DRV-M-HA (A), ABLV-M-HA (B), DUVV-M-HA (C) and EBLV-M-HA (D)
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer

Translational Oncology
Pancreatic ductal adenocarcinoma (PDAC) poses a formidable challenge in oncology due to its limited treatment options and poor long-term survival rates. Our previous work identified MG53, a member of the tripartite motif family protein (TRIM72), as a key
Xiao-Liang Wang, Xiangfei He, Tong Gao, Xinyu Zhou, Zobeida Cruz-Monserrate, Allan Tsung, Jianjie Ma, Chuanxi Cai   +7 more
doaj   +1 more source

E3 Ubiquitin Ligases: Structures, Biological Functions, Diseases, and Therapy

MedComm, Volume 6, Issue 12, December 2025.
E3 ligases function as critical regulators of cellular protein degradation, and their dysregulation is a core pathogenic mechanism in a wide array of human diseases, including cancer, cardiovascular conditions, neurodegenerative disorders, and autoimmune diseases.
Haochen Wang, Junbo Peng, Hongchan Li, Yuzhe Lan, Jing Guo, Qiang Qiu, Xuan Huang   +6 more
wiley   +1 more source

Model for TRIM72 restricts lyssavirus assembly and/or release by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein. [PDF]

Model for TRIM72 restricts lyssavirus assembly and/or release by inducing K48-linked ubiquitination and proteasome degradation of the matrix protein.
Ling Zhao (111365), Baokun Sui (813274), Ming Zhou (73279), Jiaxin Zheng (1440334), Zhenfang Fu (18056629)   +4 more
core   +1 more source

The Role of Ferroptosis in Women's Health and Diseases

MedComm, Volume 6, Issue 8, August 2025.
At present, there are many common women's diseases, such as preeclampsia (PE), ovarian cancer, and cervical cancer, endangering women's health. These diseases all over the world are characterized by high morbidity and mortality. In the past decade, ferroptosis, a unique pattern of programmed cell death primarily driven by iron‐dependent phospholipid ...
Qiang Xu, Chongying Zhu, Lin Li, Jiayong Li, Zihao An, Chao Tang   +5 more
wiley   +1 more source

Reverse phase protein arrays for the identification/validation of biomarkers of beef texture and their use for early classification of carcasses [PDF]

, 2018
article in PressThe validation of biomarkers and tools for the prediction of beef texture remains a challenging task. In this study, reverse phase protein arrays (RPPA) quantified 29 protein biomarkers in the m.
Muriel Bonnet, Marie-Pierre Ellies-Oury, Brigitte Picard, Ellies, Marie-Pierre, de Koning, Leanne, Mohammed Gagaoua, Bonnet, Muriel, Leanne De Koning, Gagaoua, Mohammed, Picard, Brigitte   +9 more
core   +1 more source

COTE1 Regulates AMPKα2 Deubiquitination by Targeting WWP1 Activation to Promote Proliferation and Autophagy in Small Cell Lung Cancer

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 7, July 2025.
COTE1 regulates the protein stability of AMPKα, maintaining the balance of cellular autophagy and promoting tumor proliferation and survival. ABSTRACT COTE1 expression is significantly upregulated in small cell lung cancer (SCLC) tissues compared to normal lung tissues and promotes SCLC cell proliferation and migration.
Yuhui Ma, Bin Song, Hongxia Guo, Ying Chen, Caihong Cao, Yuchen Hao, Yanmin Zheng, Xu Li   +7 more
wiley   +1 more source

Caveolin-3, MURC and Trim72 predict myogenic differentiation in the human embryonal rhabdomyosarcoma RD cell line [PDF]

, 2017
Caveolin-3 (Cav-3), muscle-restricted coiled coil MURC (also referred to as Cavin-4) and the recently identified large tripartite motif Trim72 are proteins controlling a number of important processes in skeletal muscle, ranging from myogenesis and ...
CODENOTTI, SILVIA, FANZANI, Alessandro, Bonazza, F, GAVAZZI, SARA   +3 more
core   +1 more source

Chronic aerobic exercise improves insulin sensitivity and modulates Nrf2 and NF‑κB/IκBα pathways in the skeletal muscle of rats fed with a high fat diet [PDF]

, 2019
The present study aimed to investigate the molecular mechanisms of the ameliorative effects of chronic aerobic exercise on non‑alcoholic steatohepatitis (NASH) in rat skeletal muscle.
Xia, Z, Liong, EC, Yu, Q, Tipoe, GL
core   +1 more source