Results 111 to 120 of about 868 (158)

Cell-autonomous and non-cell-autonomous effect of TRIM72 on ALS disease progression

Abstract Dysfunction of RNA-binding proteins, including TDP-43 and FUS, has been associated with amyotrophic lateral sclerosis (ALS); however, the underlying mechanisms are largely unknown. Here, we reported that a neuronal upregulation of TRIM72 (Tripartite Motif Containing 72) in FUS mutation knockin ALS models slows disease ...
Xue Zhang, Ji He, Ning Song, Xipeng Li, Weizhe Wang, Yueting Hu, Qing Li, Yiqing Hu, Chunmu Yin, Peng Zhao, Xinyi Jiang, Xuejiao Piao, Dawei Meng, Hongmei Cheng, Zhaohui Chen, Xusheng Huang, Pan Yu, Xinming Qi, Jin Ren, Li Luo, Lin Peng, Wei Guo, Tong Wang, Haipeng Gong, Dongsheng Fan, Yichang Jia   +25 more
openaire   +1 more source

NINJ1 ubiquitination by TRIM72 protects against plasma membrane rupture and AKI-CKD progression

Cell Death & Differentiation
Abstract The progression of acute kidney injury (AKI) to chronic kidney disease (CKD) remains a major clinical challenge. It is primarily triggered by renal tubular epithelial cell (RTEC) death that leads to persistent sterile inflammation, maladaptive repair and irreversible renal fibrosis.
Keng Ye, Siyi Lin, Caiming Chen, Zhimin Chen, Kongwen Lin, Guoping Li, Huabin Ma, Jianfeng Wu, Tak W. Mak, Li Chen, Yanfang Xu   +10 more
openaire   +1 more source

Estudis funcionals de la disferlina i aproximacions terapèutiques en un model murí de miopatia per dèficit de disferlina [PDF]

, 2013
Les disferlinopaties són un grup de distròfies musculars causades per mutacions al gen DYSF. El gen DYSF codifica per la proteïna disferlina, la qual s’expressa en diversos teixits però és especialment important en el múscul esquelètic i en els ...
Flix Ordóñez, Bàrbara
core  

Deciphering the role of the hendecad-repeat coiled-coil domain of TRIM72 in membrane curvature recognition

Abstract RING-type E3 ubiquitin ligases are functional multidomain proteins involved in diverse eukaryotic cellular processes. A major subfamily of RING-type ligases is the tripartite motif (TRIM)-containing protein family, whose members contain RING, B-box, coiled-coil, and variable C-terminal domains.
Hyun Kyu Song, Si Hoon Park
openaire   +1 more source

Emerging Role and Potential Therapeutic Application of TRIM Proteins in Cardiovascular Diseases. [PDF]

Biomolecules
Cui Y, Wen Y, Wang X, Xu Y, Jiang M.
europepmc   +1 more source

Decreased serum MG53 levels are associated with SHBG and androgen excess in women with polycystic ovary syndrome. [PDF]

Sci Rep
Coşkun ES, Gencer FK, Salman S, Nurlu N, Bacak HB, Kumbasar S, Timur GY, Çelikoğlu E, Ünlü Ş, Tunççağ F, Güven R.   +10 more
europepmc   +1 more source

Current and Emerging Therapeutic Strategies for the Treatment of Duchenne Muscular Dystrophy. [PDF]

Genes (Basel)
Lopez Perez MA, Weisleder NL.
europepmc   +1 more source

Ubiquitin E3 Ligases and p53 in Doxorubicin-Induced Cardiotoxicity. [PDF]

Int J Mol Sci
Tachibana S, Otaki Y, Goto J, Watanabe T, Watanabe M.   +4 more
europepmc   +1 more source

Roles and Mechanisms of TRIM Family Proteins in Inflammation in the Brain and Beyond. [PDF]

Int J Mol Sci
Gerasimova T, Kotok A, Saltykova S, Stepanenko E, Eremeev A, Novosadova E, Tarantul V, Nenasheva V.   +7 more
europepmc   +1 more source

TRIM72 Alleviates Muscle Inflammation in mdx Mice via Promoting Mitophagy-Mediated NLRP3 Inflammasome Inactivation. [PDF]

Oxid Med Cell Longev, 2023
Wu M, Li H, He J, Liang J, Liu Y, Zhang W.   +5 more
europepmc   +1 more source