Results 41 to 50 of about 1,176 (169)
Association Between Lower Serum Mitsugumin 53 Levels and the Risk of Vascular Calcification in Hemodialysis Patients [PDF]
International Journal of Nephrology and Renovascular DiseaseWenwen Ren,1 Conghui Liu,1 Ying Yan,1 Ming Han,2– 5 Pan Xiang,6 Qi Pang,1 Aihua Zhang1,7 1Department of Nephrology, Xuanwu Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Beijing Key Laboratory of Emerging Infectious Diseases,
Ren W +6 more
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An MG53-IRS1-interaction disruptor ameliorates insulin resistance [PDF]
Experimental and Molecular Medicine, 2018 Diabetes: lowering glucose levels by targeting protein interactions A promising drug candidate for type II diabetes targets a protein interaction involved in insulin resistance.
Jun Sub Park +9 more
doaj +3 more sources
MG53蛋白对小鼠阿霉素急性心肌毒性的影响及机制 [PDF]
Zhongshan Daxue xuebao. Yixue kexue ban, 2023 目的本研究拟探究MG53蛋白对小鼠阿霉素心肌毒性的心脏功能的影响及机制。方法体内实验选择C57BL/6小鼠腹腔注射阿霉素20 mg/kg 1周诱导急性阿霉素心肌毒性模型；体外实验使用1 μmol/L阿霉素处理大鼠原代心肌细胞构建DIC模型。采用小动物心脏超声分析小鼠心脏功能，观察左室射血分数、缩短分数的变化；通过qPCR技术分析心脏重构相关基因ANP、BNP、α-MHC，自噬相关基因Beclin1、LC3及凋亡基因CASPASE3的表达改变；采用免疫印迹技术检测自噬相关蛋白Beclin1 ...
卢维哲 +4 more
doaj +3 more sources
MG53 suppresses interferon-β and inflammation via regulation of ryanodine receptor-mediated intracellular calcium signaling [PDF]
Nature Communications, 2020 TRIM proteins are known to play critical roles in the context of viral infection. Here the authors establish MG53 (TRIM72) suppresses IFN and inflammation by modulation of ryanodine receptor related intracellular calcium induction.
Matthew Sermersheim +11 more
doaj +2 more sources
MG53-induced IRS-1 ubiquitination negatively regulates skeletal myogenesis and insulin signalling [PDF]
, 2013 Mitsugumin 53 (MG53) negatively regulates skeletal myogenesis by targeting insulin receptor substrate 1 (IRS-1). Here, we show that MG53 is an ubiquitin E3 ligase that induces IRS-1 ubiquitination with the help of an E2-conjugating enzyme, UBE2H ...
Nguyễn, Thị Huỳnh Nga
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Cryo-EM structure of human MG53 homodimer
Biochemical Journal, 2022 MG53 is a tripartite motif (TRIM) family E3 ligase and plays important biological functions. Here we present the cryo-EM structure of human MG53, showing that MG53 is a homodimer consisting of a ‘body’ and two ‘wings’. Intermolecular interactions are mainly distributed in the ‘body’ which is relatively stable, while two ‘wings’ are more dynamic.
Yange Niu +5 more
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Molecular Cancer, 2021 Background Cancer cells develop resistance to chemotherapeutic intervention by excessive formation of stress granules (SGs), which are modulated by an oncogenic protein G3BP2.
Haichang Li +16 more
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MG53 as a Novel Therapeutic Protein to Treat Acute Lung Injury [PDF]
Military Medicine, 2021 ABSTRACT Introduction Lung injury has several inciting etiologies ranging from trauma (contusion and hemorrhage) to ischemia reperfusion injury. Reflective of the injury, tissue and cellular injury increases proportionally with the injury stress and is an area of potential intervention to mitigate the
Bryan A, Whitson +8 more
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Effect of metabolic syndrome on mitsugumin 53 expression and function. [PDF]
PLoS ONE, 2015 Metabolic syndrome is a cluster of risk factors, such as obesity, insulin resistance, and hyperlipidemia that increases the individual's likelihood of developing cardiovascular diseases. Patients inflicted with metabolic disorders also suffer from tissue
Hanley Ma +12 more
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MG53: Biological Function and Potential as a Therapeutic Target [PDF]
Molecular Pharmacology, 2017 MG53 (también conocido como motivo tripartito, TRIM72) es una proteína de la familia TRIM específica del músculo cardíaco y esquelético que exhibe múltiples funciones biológicas. Primero, MG53 participa en la reparación de la membrana plasmática del corazón, el músculo esquelético y otros tejidos.
Yan Zhang +3 more
openaire +2 more sources