Results 21 to 30 of about 1,176 (169)

MG53′s new identity [PDF]

Skeletal Muscle, 2013
Abstract Mitsugumin 53 (MG53) is a relatively newly identified tripartite motif-containing (TRIM) family muscle-specific E3 ubiquitin ligase that is expressed in skeletal muscle and the heart. It has been postulated to facilitate repair by targeting the site of an injury, and acting as a scaffold for assembly of a repair complex made up of ...
Levy, Jennifer R, Campbell, Kevin P, Glass, David J   +2 more
openaire   +4 more sources

Association of MG53 with presence of type 2 diabetes mellitus, glycemic control, and diabetic complications. [PDF]

PLoS ONE, 2023
ObjectivesMitsugumin 53 (MG53) is a myokine that acts as a membrane repair protein in tissues. Data on the effect of MG53 on insulin signaling and type 2 diabetes mellitus (T2 DM) are still unknown; most are from preclinical studies.
Burak Andaç, Eray Özgün, Buket Yılmaz Bülbül, Serpil Yanık Çolak, Mine Okur, Ali Cem Yekdeş, Eftal Öcal, Mehmet Emin Tapan, Mehmet Çelik   +8 more
doaj   +2 more sources

MG53 Constitutes a Primary Determinant of Cardiac Ischemic Preconditioning [PDF]

Circulation, 2010
Background— Ischemic heart disease is the greatest cause of death in Western countries. The deleterious effects of cardiac ischemia are ameliorated by ischemic preconditioning (IPC), in which transient ischemia protects against subsequent severe ischemia/reperfusion ...
Chun-Mei, Cao, Yan, Zhang, Noah, Weisleder, Christopher, Ferrante, Xianhua, Wang, Fengxiang, Lv, Yi, Zhang, Ruisheng, Song, Moonsun, Hwang, Li, Jin, Jiaojiao, Guo, Wei, Peng, Geng, Li, Miyuki, Nishi, Hiroshi, Takeshima, Jianjie, Ma, Rui-Ping, Xiao   +16 more
openaire   +4 more sources

Cardiac effects and clinical applications of MG53 [PDF]

Cell & Bioscience, 2021
Heart disease remains the leading cause of mortality globally, so further investigation is required to identify its underlying mechanisms and potential targets for treatment and prevention.
Weina Zhong, Dathe Z. Benissan-Messan, Jianjie Ma, Chuanxi Cai, Peter H. U. Lee   +4 more
doaj   +3 more sources

MG53 protects against septic cardiac dysfunction by ubiquitinating ATF2 [PDF]

Journal of Advanced Research
Septic cardiac dysfunction (SCD) is the most common complication of sepsis, which has become the primary cause of death in intensive care units. The muscle-specific protein mitsugumin-53 (MG53) has been identified to protect cell integrity as a "Molecular Band-Aid".The recombinant human MG53 (rhMG53) pretreatment has been reported to prevent cardiac ...
Hongmei Ren
exaly   +5 more sources

MG53 participates in ischaemic postconditioning through the RISK signalling pathway [PDF]

Cardiovascular Research, 2011
Recent studies show that ischaemic postconditioning (PostC), similar to the well-established ischaemic preconditioning (IPC), confers cardioprotection against ischaemia/reperfusion (IR) injury, and both IPC and PostC can activate the reperfusion injury salvage kinase (RISK) pathway and the survivor activating factor enhancement (SAFE) pathway. PostC is
Yan, Zhang, Fengxiang, Lv, Li, Jin, Wei, Peng, Ruisheng, Song, Jianjie, Ma, Chun-Mei, Cao, Rui-Ping, Xiao   +7 more
openaire   +4 more sources

N‐acetylcysteine prevents oxidized low‐density lipoprotein‐induced reduction of MG53 and enhances MG53 protective effect on bone marrow stem cells [PDF]

Journal of Cellular and Molecular Medicine, 2019
AbstractMG53 is an important membrane repair protein and partially protects bone marrow multipotent adult progenitor cells (MAPCs) against oxidized low‐density lipoprotein (ox‐LDL). The present study was to test the hypothesis that the limited protective effect of MG53 on MAPCs was due to ox‐LDL‐induced reduction of MG53.
Li, Xin, Jiang, Meng, Tan, Tao, Narasimhulu, Chandrakala A., Xiao, Yuan, Hao, Hong, Cui, Yuqi, Zhang, Jia, Liu, Lingjuan, Yang, Chunlin, Li, Yixi, Ma, Jianjie, Verfaillie, Catherine M., Parthasarathy, Sampath, Zhu, Hua, Liu, Zhenguo   +15 more
openaire   +5 more sources

MG53: A potential therapeutic target for kidney disease

Pharmacology Research & Perspectives, 2023
Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease.
Ben Ke, Wen Shen, Jianling Song, Xiangdong Fang   +3 more
doaj   +3 more sources

Recombinant TRIM72/MG53 protein enhances plasma membrane repair and reduces neurotoxicity in models of Alzheimer’s Disease [PDF]

Alzheimers Dement
Abstract Background Amyloid beta (Aβ) is one of the earliest hallmarks in Alzheimer’s Disease (AD) that has been shown to localize with the plasma membrane, decrease membrane integrity, elevate intracellular calcium concentrations, increase oxidative stress and directly induce membrane damage.
Bulgart H, Perez M, Giarrano G, Wold L, Scharre D, Weisleder N.   +5 more
europepmc   +2 more sources

Mitsugumin 53 drives stem cell differentiation easing intestinal injury and inflammation [PDF]

Signal Transduction and Targeted Therapy
Emerging evidence suggests that priming intestinal stem cells (ISCs) towards secretory progenitor cells is beneficial for maintaining gut homeostasis against inflammatory bowel disease (IBD).
Yumeng Pei, Meng Fang, Hong-Kun Wu, Qionghua Cui, Li Quan, Xiaochuan Li, Keyi Zhang, Peng Xie, Peng Jiang, Yuan Liu, Meimei Huang, Fengxiang Lv, Xiaomin Hu, Ye-Guang Chen, Xinli Hu, Rui-Ping Xiao   +15 more
doaj   +2 more sources