Advances in the Study of MG53 in Cardiovascular Disease [PDF]
International Journal of General Medicine, 2023 Shan-Mei Liu,1,* Qin Zhao,1,* Wen-Jun Li,2 Jian-Quan Zhao1 1Bayannur Hospital Department of Cardiology, Bayannur City, Inner Mongolia, 015000, People’s Republic of China; 2Tangshan Central Hospital, Tangshan, Hebei, 063008, People’s Republic of ...
Liu SM, Zhao Q, Li WJ, Zhao JQ
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MG53/TRIM72: multi-organ repair protein and beyond [PDF]
Frontiers in PhysiologyMG53, a member of the tripartite motif protein family, possesses multiple functionalities due to its classic membrane repair function, anti-inflammatory ability, and E3 ubiquitin ligase properties.
Yong-Fei Wang +9 more
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MG53 Mitigates Nitrogen Mustard-Induced Skin Injury [PDF]
Cells, 2023 Sulfur mustard (SM) and nitrogen mustard (NM) are vesicant agents that cause skin injury and blistering through complicated cellular events, involving DNA damage, free radical formation, and lipid peroxidation.
Haichang Li +9 more
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MG53 is not a critical regulator of insulin signaling pathway in skeletal muscle. [PDF]
PLoS ONE, 2021 In type 2 diabetes (T2D), both muscle and liver are severely resistant to insulin action. Muscle insulin resistance accounts for more than 80% of the impairment in total body glucose disposal in T2D patients and is often characterized by an impaired ...
Clothilde Philouze +7 more
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The Relationship Between Serum MG53 Levels and the Presence of Metabolic Syndrome and Its Components [PDF]
MedicinaBackground and Objectives: MG53 is a myokine/cardiokine involved in membrane repair. Some preclinical studies suggest that it is associated with insulin resistance.
Serpil Yanık Çolak +7 more
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MG53, A Tissue Repair Protein with Broad Applications in Regenerative Medicine [PDF]
Cells, 2021 Under natural conditions, injured cells can be repaired rapidly through inherent biological processes. However, in the case of diabetes, cardiovascular disease, muscular dystrophy, and other degenerative conditions, the natural repair process is impaired.
Zhongguang Li +6 more
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Prognostic Value of Circulating MG53 Levels in Acute Myocardial Infarction [PDF]
Frontiers in Cardiovascular Medicine, 2020 Background: Mitsugumin 53 (MG53), a muscle-specific protein belonging to the TRIM family, has been demonstrated to protect the heart against oxidative injury. Although previous studies indicated that ischemic hearts released MG53 into circulation in mice,
Hui Han, Zhu Jinzhou, Zhengbin Zhu
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Pulsed radiofrequency alleviates neuropathic pain by upregulating MG53 to inhibit microglial activation [PDF]
European Journal of Medical ResearchBackground Patients with neuropathic pain (NP) have significantly lower quality of life. Because the pathophysiology of NP is not fully understood, there is a lack of effective treatment for it in clinic.
Yuanxin Huang +8 more
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MG53 Preserves Neuromuscular Junction Integrity and Alleviates ALS Disease Progression [PDF]
Antioxidants, 2021 Respiratory failure from progressive respiratory muscle weakness is the most common cause of death in amyotrophic lateral sclerosis (ALS). Defects in neuromuscular junctions (NMJs) and progressive NMJ loss occur at early stages, thus stabilizing and ...
Jianxun Yi +11 more
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MG53 suppresses tumor growth via transcriptional inhibition of KIF11 in pancreatic cancer [PDF]
Translational OncologyPancreatic ductal adenocarcinoma (PDAC) poses a formidable challenge in oncology due to its limited treatment options and poor long-term survival rates. Our previous work identified MG53, a member of the tripartite motif family protein (TRIM72), as a key
Xiao-Liang Wang +7 more
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