Results 31 to 40 of about 470,592 (258)
Membrane repair and immunological danger [PDF]
EMBO reports, 2005 Antigens are able to elicit productive immune responses only when second signals are provided by adjuvant molecules. It is well established that exogenously acquired, pathogen‐associated molecular patterns fulfil this adjuvant role when recognized by specific receptors on antigen‐presenting cells.
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The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2018 Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash ...
Gernot Fruhmann +7 more
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Biology, 2020 Fer1L5 is a dysferlin and myoferlin related protein, which has been predicted to have a role in vesicle trafficking and muscle membrane fusion events. Mutations in dysferlin and otoferlin genes cause heredity diseases: muscular dystrophy and deafness in ...
R. Usha Kalyani +8 more
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Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells
Membranes, 2022 Defects in membrane repair contribute to the development of muscular dystrophies, such as Miyoshi muscular dystrophy 1, limb girdle muscular dystrophy (LGMD), type R2 or R12.
Coralie Croissant +4 more
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Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B
Cells, 2021 Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting.
Mary L. Vallecillo-Zúniga +14 more
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Membrane Repair: Mechanisms and Pathophysiology
Physiological Reviews, 2015 Eukaryotic cells have been confronted throughout their evolution with potentially lethal plasma membrane injuries, including those caused by osmotic stress, by infection from bacterial toxins and parasites, and by mechanical and ischemic stress. The wounded cell can survive if a rapid repair response is mounted that restores boundary integrity. Calcium
Sandra T, Cooper, Paul L, McNeil
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Eardrum regeneration: membrane repair [PDF]
Nature, 2017 Can tissue engineering provide a cheap and convenient alternative to surgery for eardrum repair?
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Toxins, 2018 The largest superfamily of bacterial virulence factors is pore-forming toxins (PFTs). PFTs are secreted by both pathogenic and non-pathogenic bacteria. PFTs sometimes kill or induce pro-pathogen signaling in mammalian cells, all primarily through plasma ...
Sucharit Ray +2 more
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Coping with the calcium overload caused by cell injury: ER to the rescue
Cell Stress, 2021 Cells maintain their cytosolic calcium (Ca2+) in nanomolar range and use controlled increase in Ca2+ for intracellular signaling. With the extracellular Ca2+ in the millimolar range, there is a steep Ca2+ gradient across the plasma membrane (PM).
Goutam Chandra +2 more
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Membrane fusion in muscle development and repair [PDF]
Seminars in Cell & Developmental Biology, 2015 Mature skeletal muscle forms from the fusion of skeletal muscle precursor cells, myoblasts. Myoblasts fuse to other myoblasts to generate multinucleate myotubes during myogenesis, and myoblasts also fuse to other myotubes during muscle growth and repair.
Alexis R, Demonbreun +2 more
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