Results 41 to 50 of about 747,654 (296)
The Impact of ESCRT on Aβ1-42 Induced Membrane Lesions in a Yeast Model for Alzheimer’s Disease
Frontiers in Molecular Neuroscience, 2018 Aβ metabolism plays a pivotal role in Alzheimer’s disease. Here, we used a yeast model to monitor Aβ42 toxicity when entering the secretory pathway and demonstrate that processing in, and exit from the endoplasmic reticulum (ER) is required to unleash ...
Gernot Fruhmann +7 more
doaj +1 more source
Biology, 2020 Fer1L5 is a dysferlin and myoferlin related protein, which has been predicted to have a role in vesicle trafficking and muscle membrane fusion events. Mutations in dysferlin and otoferlin genes cause heredity diseases: muscular dystrophy and deafness in ...
R. Usha Kalyani +8 more
doaj +1 more source
Trafficking of Annexins during Membrane Repair in Human Skeletal Muscle Cells
Membranes, 2022 Defects in membrane repair contribute to the development of muscular dystrophies, such as Miyoshi muscular dystrophy 1, limb girdle muscular dystrophy (LGMD), type R2 or R12.
Coralie Croissant +4 more
doaj +1 more source
Membrane repair and immunological danger [PDF]
EMBO reports, 2005 Antigens are able to elicit productive immune responses only when second signals are provided by adjuvant molecules. It is well established that exogenously acquired, pathogen‐associated molecular patterns fulfil this adjuvant role when recognized by specific receptors on antigen‐presenting cells.
openaire +2 more sources
Tissue engineering a fetal membrane [PDF]
, 2011 The aim of this study was to construct an artificial fetal membrane (FM) by combination of human amniotic epithelial stem cells (hAESCs) and a mechanically enhanced collagen scaffold containing encapsulated human amniotic stromal fibroblasts (hASFs ...
Adam M. Squires +11 more
core +1 more source
Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B
Cells, 2021 Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting.
Mary L. Vallecillo-Zúniga +14 more
doaj +1 more source
Toxins, 2018 The largest superfamily of bacterial virulence factors is pore-forming toxins (PFTs). PFTs are secreted by both pathogenic and non-pathogenic bacteria. PFTs sometimes kill or induce pro-pathogen signaling in mammalian cells, all primarily through plasma ...
Sucharit Ray +2 more
doaj +1 more source
Coping with the calcium overload caused by cell injury: ER to the rescue
Cell Stress, 2021 Cells maintain their cytosolic calcium (Ca2+) in nanomolar range and use controlled increase in Ca2+ for intracellular signaling. With the extracellular Ca2+ in the millimolar range, there is a steep Ca2+ gradient across the plasma membrane (PM).
Goutam Chandra +2 more
doaj +1 more source
Nuclear rupture at sites of high curvature compromises retention of DNA repair factors. [PDF]
, 2018 The nucleus is physically linked to the cytoskeleton, adhesions, and extracellular matrix-all of which sustain forces, but their relationships to DNA damage are obscure. We show that nuclear rupture with cytoplasmic mislocalization of multiple DNA repair
Alshareeda +64 more
core +2 more sources
Comparative genomics of Burkholderia multivorans, a ubiquitous pathogen with a highly conserved genomic structure [PDF]
, 2017 The natural environment serves as a reservoir of opportunistic pathogens. A well-established method for studying the epidemiology of such opportunists is multilocus sequence typing, which in many cases has defined strains predisposed to causing infection.
Peeters, Charlotte +5 more
core +3 more sources