Results 51 to 60 of about 483,797 (293)

Therapeutic Benefit of Galectin-1: Beyond Membrane Repair, a Multifaceted Approach to LGMD2B

Cells, 2021
Two of the main pathologies characterizing dysferlinopathies are disrupted muscle membrane repair and chronic inflammation, which lead to symptoms of muscle weakness and wasting.
Mary L. Vallecillo-Zúniga, Peter Daniel Poulson, Jacob S. Luddington, Christian J. Arnold, Matthew Rathgeber, Braden C. Kartchner, Spencer Hayes, Hailie Gill, Jonard C. Valdoz, Jonathan L. Spallino, Seth Garfield, Ethan L. Dodson, Connie M. Arthur, Sean R. Stowell, Pam M. Van Ry   +14 more
doaj   +1 more source

Membrane Repair: Mechanisms and Pathophysiology

Physiological Reviews, 2015
Eukaryotic cells have been confronted throughout their evolution with potentially lethal plasma membrane injuries, including those caused by osmotic stress, by infection from bacterial toxins and parasites, and by mechanical and ischemic stress. The wounded cell can survive if a rapid repair response is mounted that restores boundary integrity. Calcium
Sandra T, Cooper, Paul L, McNeil
openaire   +3 more sources

Differential cartilaginous tissue formation by human synovial membrane, fat pad, meniscus cells and articular chondrocytes [PDF]

, 2007
Objective: To identify an appropriate cell source for the generation of meniscus substitutes, among those which would be available by arthroscopy of injured knee joints.
A. Marsano, Jakob, M., I. Martin, E. Kon, Tognana, E., Nehrer, S., D.M. Salter, E. Tognana, Marsano, A., Adesida, A., Hardingham, T., Salter, D.M., S.J. Millward-Sadler, Salter, D. M., A. Adesida, S. Nehrer, T. Hardingham, Chiari-Grisar, C., Kon, E., Martin, I., Millward-Sadler, S. J., M. Jakob, C. Chiari-Grisar, Millward-Sadler, S.J.   +23 more
core   +1 more source

Eardrum regeneration: membrane repair [PDF]

Nature, 2017
Can tissue engineering provide a cheap and convenient alternative to surgery for eardrum repair?
openaire   +2 more sources

Crystal structures of the human Dysferlin inner DysF domain [PDF]

, 2014
Background: Mutations in dysferlin, the first protein linked with the cell membrane repair mechanism, causes a group of muscular dystrophies called dysferlinopathies.
Cole, Ambrose R., Nicholas H Keep, Keep, Nicholas H., Altin Sula, Sula, Altin, Orengo, C., Ambrose R Cole, Corin Yeats, Yeats, C., Christine Orengo   +9 more
core   +1 more source

Phobalysin: Fisheye View of Membrane Perforation, Repair, Chemotaxis and Adhesion

Toxins, 2019
Phobalysin P (PhlyP, for photobacterial lysin encoded on a plasmid) is a recently described small β-pore forming toxin of Photobacterium damselae subsp. damselae (Pdd).
Gisela von Hoven, Amable J. Rivas, Matthias Husmann   +2 more
doaj   +1 more source

Coping with the calcium overload caused by cell injury: ER to the rescue

Cell Stress, 2021
Cells maintain their cytosolic calcium (Ca2+) in nanomolar range and use controlled increase in Ca2+ for intracellular signaling. With the extracellular Ca2+ in the millimolar range, there is a steep Ca2+ gradient across the plasma membrane (PM).
Goutam Chandra, Davi A. G. Mázala, Jyoti K. Jaiswal   +2 more
doaj   +1 more source

Membrane Binding, Cellular Cholesterol Content and Resealing Capacity Contribute to Epithelial Cell Damage Induced by Suilysin of Streptococcus suis

Pathogens, 2019
Streptococcus (S.) suis is a major cause of economic losses in the pig industry worldwide and is an emerging zoonotic pathogen. One important virulence-associated factor is suilysin (SLY), a toxin that belongs to the family of cholesterol-dependent pore ...
Désirée Vötsch, Maren Willenborg, Walter M.R. Oelemann, Graham Brogden, Peter Valentin-Weigand   +4 more
doaj   +1 more source

Membrane repair: Ca2+-elicited lysosomal exocytosis [PDF]

, 2001
Cells in exposed positions are subject to injury and therefore need membrane repair mechanisms. Ca2+ entry inevitably follows membrane rupture and recent studies indicate that this elicits repair via Ca2+-activated exocytosis of lysosomes, regulated by ...
Gerasimenko, Oleg V, Ole H Petersen, Petersen, Ole Holger, Petersen, Ole H, Gerasimenko, Julia Vladimirovna, Gerasimenko, Julia V, Oleg V Gerasimenko, Julia V Gerasimenko, Gerasimenko, Oleg Vsevolodovich   +8 more
core   +1 more source

MG53: A potential therapeutic target for kidney disease

Pharmacology Research & Perspectives, 2023
Ensuring cell survival and tissue regeneration by maintaining cellular integrity is important to the pathophysiology of many human diseases, including kidney disease.
Ben Ke, Wen Shen, Jianling Song, Xiangdong Fang   +3 more
doaj   +1 more source