Results 201 to 210 of about 172,471 (314)

The profiling of extracellular vesicle subtypes in Huntington's disease brains identifies Alix as a novel marker of neuropathology. [PDF]

Acta Neuropathol Commun
Pérez-González R, Vázquez-Oliver A, Salvat-Rovira N, Martínez-Horta S, Rivas-Asensio E, Borràs E, Ortuño-Miquel S, Sánchez-Carcelén M, Garcia-Forn M, Sampedro F, Pérez-Pérez J, Sabidó E, Pérez-Navarro E, Kulisevsky J.   +13 more
europepmc   +1 more source

Thrombosis: Annexin V C/T-1 polymorphism and pregnancy complications

, 2006
Franca Franchi, Ylenia Viscardi, Irene Cetin, Paolo Bucciarelli, Ida Martinelli, Eugenia Biguzzi   +5 more
openalex   +1 more source

EDTA‐Functionalized Nanoscale Metal–Organic Framework for Onco‐Cardiology via Radiochemotherapy Synergy and Spatiotemporally Matched Iron Chelation

Advanced Science, EarlyView.
Doxorubicin (DOX)‐induced cardiotoxicity is a major limitation to its broader clinical application, while cardioprotective interventions often risk reducing the anticancer efficacy of DOX. To address these challenges, this work constructs an EDTA‐functionalized metal–organic framework that enhances tumor therapy and provides efficient cardioprotection ...
Daojing Yuan, Liyang Tian, Luwen Zhuang, Yongyu Liang, Lingfei Chen, Xuetao Wang, Yanli Li, Xiyong Yu, Teng Gong   +8 more
wiley   +1 more source

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

LIMK2 inactivation suppresses mechanical stimulation-induced dermal fibroblast differentiation and resistance to apoptosis. [PDF]

Sci Rep
Ishii M, Kuroda K, Otani N, Nakamura R, Oue T, Kawai K, Matsuzaki S, Kubo T.   +7 more
europepmc   +1 more source

Neutrophil‐Mimetic Nanoscavengers Target the Inflammatory Microenvironment to Eliminate NETs/ROS and Immunomodulate cGAS‐STING Signaling in Septic AKI

Advanced Science, EarlyView.
Sepsis‐associated acute kidney injury is driven by oxidative stress, NETs overproduction, and dysregulated innate immunity. Here, we develop neutrophil‐mimetic nanoscavengers that integrate ROS‐scavenging Mn3O4 nanozymes with DNase‐1‐mediated NETs degradation to suppress cGAS‐STING signaling, reprogram macrophage polarization, and effectively alleviate
Zening Zhang, Chenxi Zhang, Ranran Luo, Qiuchi Wu, Pengchen Ren, Xinyu Liu, Yingying Luo, Zhongsheng Xu, Xiaojing He, Yun Liu   +9 more
wiley   +1 more source

Annexin A5 Protects SH-SY5Y Cells against L-Glutamate-Induced Cytotoxicity. [PDF]

Iran J Med Sci
Abedini Z, Mehdieh M, Takhshid MA.
europepmc   +1 more source

PRELID1 and VDAC3 Coordinate a Senescence‐Like State in Germinal Center B Cells to Promote IL‐7–Driven Antitumor Immunity in Colorectal Cancer

Advanced Science, EarlyView.
Colorectal cancer is characterized by an immunosuppressive microenvironment that limits immunotherapy efficacy. We identify a senescence‐like state in germinal center B cells driven by the PRELID1–VDAC3 axis, which promotes IL‐7 secretion, alleviates CD8+ T‐cell exhaustion, and enhances antitumor immunity. Targeting this pathway improves responsiveness
Yuhan Liao, Huimeng Xu, Xinghua Zhuo, Shupeng Hu, Lanhui Huang, Zhe Hao, Jianxiong Chen, Yulu Wang, Jun Zhou   +8 more
wiley   +1 more source

miR-340 improves the efficiency of p53 gene therapy in metastatic prostate cancer cells through downregulation of MDM2. [PDF]

Sci Rep
Deyhimfar R, Kehtari M, Saadatpour F, Nikoofar A, Heshmat R, Arshadi H, Dialameh H, Arefian E, Aghamir SMK.   +8 more
europepmc   +1 more source

Multi-Omics Profiling Identifies Microglial Annexin A2 as a Key Mediator of NF-κB Pro-inflammatory Signaling in Ischemic Reperfusion Injury [PDF]

Xibin Tian, Wuyan Yang, Wei Jiang, Zhen Zhang, Junqiang Liu, Haijun Tu   +5 more
openalex   +1 more source