Results 1 to 10 of about 242,565 (165)

Annexin A2: the missing piece in the puzzle of pathogen-induced damage. [PDF]

Virulence, 2023
Annexin A2 is a Ca2+ regulated protein belonging to the Annexin family and is found in the cytoplasm and cell membrane. It can exist in a monomeric form or in a heterotetrameric form with the S100A10 dimer.
Li C, Yu J, Liao D, Su X, Yi X, Yang X, He J.   +6 more
europepmc   +3 more sources

Targeting Annexin A2 to reactivate tumor-associated antigens presentation and relieve immune tolerance in liver cancer. [PDF]

J Immunother Cancer
Background Tumor cells manipulate the tumor-associated antigens presentation to escape immune surveillance; however, the molecular mechanism is not exactly clear and the measure to intervene is missing.Methods Annexin A2 was knockout by the CRISPR-Cas9 ...
Tang Y, Yang J, Shen Q, Gao Z, Wu M, Wu C, Du J, Li M, Ling C, Lu F, Chai Y, Dong X, Qian J, Li C, Xie F, Guo Z, Shen H, Wang D.   +17 more
europepmc   +3 more sources

Annexin A2 and Kidney Diseases. [PDF]

Front Cell Dev Biol, 2022
Annexin A2 is a Ca2+- and phospholipid-binding protein which is widely expressed in various types of cells and tissues. As a multifunctional molecule, annexin A2 is found to be involved in diverse cell functions and processes, such as cell exocytosis ...
Lin L, Hu K.
europepmc   +3 more sources

Baicalin target protein, Annexin A2, is a target of new antitumor drugs. [PDF]

Sci Rep
Baicalin is a flavonoid extracted from Scutellaria baicalensis Georgi. As it has significant antitumor and apoptosis-inducing effects, baicalin may be useful as a lead compound in new antitumor drug development. However, as the pharmacological actions of
Kusakabe Y, Matsumoto K, Tsuyuki T, Hayashi Y, Watanabe H.   +4 more
europepmc   +3 more sources

Annexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice. [PDF]

Nat Commun
Proliferative vitreoretinopathy is a vision-threatening response to penetrating ocular injury, for which there is no satisfactory treatment. In this disorder, retinal pigment epithelial cells, abandon their attachment to Bruch’s membrane on the scleral ...
Luo M, Almeida D, Dallacasagrande V, Hedhli N, Gupta M, D'Amico DJ, Kiss S, Hajjar KA.   +7 more
europepmc   +3 more sources

Annexin A2: A Double-Edged Sword in Pathogen Infection. [PDF]

Pathogens
Annexin A2 (ANXA2) is a multifunctional calcium- and phospholipid-binding protein that plays an important role in various cells. During pathogen infections, ANXA2 modulates the nuclear factor kappa-B (NF-κB) and cell apoptosis signaling pathways and ...
Wang T, Zhao D, Zhang Y, Yu D, Liu G, Zhang K.   +5 more
europepmc   +3 more sources

Impact of Annexin A2 on virus life cycles. [PDF]

Virus Res
Due to the limited size of viral genomes, hijacking host machinery by the viruses taking place throughout the virus life cycle is inevitable for the survival and proliferation of the virus in the infected hosts.
Park IW, Fiadjoe HK, Chaudhary P.
europepmc   +3 more sources

Collagen-I influences the post-translational regulation, binding partners and role of Annexin A2 in breast cancer progression

Frontiers in Oncology, 2023
IntroductionThe extracellular matrix (ECM) has been heavily implicated in the development and progression of cancer. We have previously shown that Annexin A2 is integral in the migration and invasion of breast cancer cells and in the clinical progression
Amira F. Mahdi, Amira F. Mahdi, Joanne Nolan, Joanne Nolan, Ruth Í. O’Connor, Ruth Í. O’Connor, Aoife J. Lowery, Joanna M. Allardyce, Joanna M. Allardyce, Patrick A. Kiely, Patrick A. Kiely, Kieran McGourty, Kieran McGourty, Kieran McGourty   +13 more
doaj   +2 more sources

Translational implications of targeting annexin A2: From membrane repair to muscular dystrophy, cardiovascular disease and cancer

Clinical and Translational Discovery, 2023
Background Annexin A2 contributes to several key cellular functions and processes, including membrane repair. Effective repair prevents cell death and degeneration, especially in skeletal or cardiac muscle, epithelia, and endothelial cells.
Victor G. Kayejo, Hannah Fellner, Roshan Thapa, Peter A. Keyel   +3 more
doaj   +2 more sources

The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins

Biomolecules, 2021
Mutualistic symbiosis refers to the symbiotic relationship between individuals of different species in which both individuals benefit from the association.
Alamelu Bharadwaj, Emma Kempster, David Morton Waisman   +2 more
doaj   +2 more sources