Results 1 to 10 of about 15,017 (189)

Recent Advances in Molecular and Cellular Functions of S100A10

Biomolecules, 2023
S100A10 (p11, annexin II light chain, calpactin light chain) is a multifunctional protein with a wide range of physiological activity. S100A10 is unique among the S100 family members of proteins since it does not bind to Ca2+, despite its sequence and ...
Gillian C Okura, Alamelu G Bharadwaj, David M Waisman   +2 more
exaly   +6 more sources

Comparative analysis of S100A10 and S100A11 in MASLD and hepatic cancer development revealed a tumor suppressive role for S100A10. [PDF]

Cell Death Dis
S100 proteins are significantly deregulated in hepatocellular carcinoma (HCC) and metabolic dysfunction-associated steatotic liver disease (MASLD). Here, we investigated the impact of hepatocyte downregulation of two closely-related members of the S100 ...
Delangre E, Correia de Sousa M, Türkal M, Gjorgjieva M, Chartier S, Arnoux G, Sobolewski C, Fournier M, Maeder C, Rubbia-Brandt L, Maechler P, Foti M.   +11 more
europepmc   +5 more sources

Regulation of S100A10 Gene Expression [PDF]

Biomolecules, 2021
S100A10, a member of the S100 family of Ca2+-binding proteins, is a widely distributed protein involved in many cellular and extracellular processes. The best recognized role of S100A10 is the regulation, via interaction with annexin A2, of plasminogen ...
Pawel Bieganowski, Ewelina Jurewicz, Wiesława Leśniak   +2 more
exaly   +5 more sources

The Annexin A2/S100A10 Complex: The Mutualistic Symbiosis of Two Distinct Proteins

Biomolecules, 2021
Mutualistic symbiosis refers to the symbiotic relationship between individuals of different species in which both individuals benefit from the association.
David M Waisman
exaly   +3 more sources

S100A10 promotes HCC development and progression via transfer in extracellular vesicles and regulating their protein cargos [PDF]

Gut, 2023
Objective Growing evidence indicates that tumour cells exhibit characteristics similar to their lineage progenitor cells. We found that S100 calcium binding protein A10 (S100A10) exhibited an expression pattern similar to that of liver progenitor genes ...
Xia Wang, Hongyang Huang, K. Sze, Jin Wang, Lu Tian, J. Lu, Y. Tsui, H. Ma, Eva K. Lee, Ao Chen, J. Lee, Ying Wang, J. Yam, T. Cheung, Xinyuan Guan, I. Ng   +15 more
semanticscholar   +2 more sources

S100A10 knockdown exacerbates phenylephrine-induced cardiomyocyte hypertrophy via modulating mitochondrial oxidative phosphorylation. [PDF]

Front Genet
Background Mitochondrial dysfunction is a well-established hallmark of pathological cardiac hypertrophy, though its underlying mechanisms are not fully understood.
Xu F, Chen Y, Xu M, Li D, Lu Y, Zhang M, Li J, Li W, Guo Y.   +8 more
europepmc   +2 more sources

Hypoxia Upregulates RIPK1 via the HIF-1α-JAK-STAT Pathway Leading to Astrocyte Necroptosis to Promote Cavitation After Spinal Cord Injury. [PDF]

CNS Neurosci Ther
Abstract This study established a rat spinal cord injury (SCI) model and an in vitro hypoxic astrocyte model, confirming that hypoxia promotes the formation of the cavity of injury (COI) after SCI by activating the HIF‐1α/JAK/STAT pathway, which in turn induces astrocytic necroptosis and ultimately drives the pathological progression of SCI.
Bi H, Zhang W, Duan H, Wang C, Shen X, Jiang G, Xue H, Yan R, Xu Y, Zhang Y, Zhao H, He F, Wang Z.   +12 more
europepmc   +2 more sources

Low 5HT_1B and 5HT₄ Receptor Neurotransmission as a Potential Link Between Cholesterol Metabolism and Suicide Risk. [PDF]

J Neurochem
Stress and inflammatory signals (e.g., IL‐6, TNFα, cortisol) may disrupt cholesterol metabolism and membrane microdomains known as lipid rafts. This can impair the function of serotonin receptors (5‐HT1B and 5‐HT4) that regulate impulsive behavior.
Kalkman HO, Smigielski L.
europepmc   +2 more sources

Multi-omics analyses integration reveals a novel TRF2-miR-181a-5p-S100A10 regulatory axis in colon cancer. [PDF]

Cell Mol Biol Lett
The Telomeric repeat-binding factor 2 (TRF2) binds to TTAGGG repeats located at chromosomes ends and ensures telomere protection together with the other members of shelterin.
Dinami R, Petti E, Ostano P, Iachettini S, Rizzo A, Maresca C, Zizza P, Di Vito S, Porru M, D'Angelo C, Sibilio P, De Nicola F, Russo R, Di Benedetto A, Palange A, Fanciulli M, Chambery A, Gilson E, Biroccio A.   +18 more
europepmc   +2 more sources

The origins and dynamic changes of C3- and S100A10-positive reactive astrocytes after spinal cord injury

Frontiers in Cellular Neuroscience, 2023
Accaumulating studies focus on the effects of C3-positive A1-like phenotypes and S100A10-positive A2-like phenotypes of reactive astrocytes on spinal cord injury (SCI), however the origins and dynamic changes of C3- and S100A10-positive reactive ...
Liming Cheng, Ning Xie, Cheng Li-Ming
exaly   +2 more sources