The impact of C216T and hot spot mutations of the TERT promoter on the clinicopathologic characteristics and S100A10 expression in papillary thyroid carcinoma: a comparative study. [PDF]
Diagn PatholThe C216T mutation in the TERT promoter (TERTp) is a rarely reported genetic alteration in papillary thyroid carcinoma (PTC). Its clinical significance remains unclear. This study aimed to compare the impact of the C216T and hot spot mutations (C228T and
Li P, Huang C, Liu X, Gui H, Li J.
europepmc +2 more sources
S100A10 promotes cancer metastasis via recruitment of MDSCs within the lungs
OncoimmunologyTumor-derived exosomes bind to organ resident cells, activating S100 molecules during the remodeling of the local immune microenvironment. However, little is known regarding how organ resident cell S100A10 mediates cancer metastatic progression. Here, we
Juan Li +10 more
semanticscholar +2 more sources
The biochemistry and regulation of S100A10: a multifunctional plasminogen receptor involved in oncogenesis [PDF]
Journal of Biomedicine and Biotechnology, 2012 The plasminogen receptors mediate the production and localization to the cell surface of the broad spectrum proteinase, plasmin. S100A10 is a key regulator of cellular plasmin production and may account for as much as 50% of cellular plasmin generation ...
O'Connell, Paul A. +4 more
core +5 more sources
Differential expression of S100A10 in amyotrophic lateral sclerosis.
, 2022 Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2).
Shahan Mamoor
core +2 more sources
S100A10 and its binding partners in depression and antidepressant actions
Frontiers in Molecular Neuroscience, 2022 S100A10 (p11) is an emerging player in the neurobiology of depression and antidepressant actions. p11 was initially thought to be a modulator of serotonin receptor (5-HTR) trafficking and serotonergic transmission, though newly identified binding ...
Michelle Chen, Y. Oh, Yong Kim
semanticscholar +5 more sources
The clinical significance of S100A10 in pancreatic cancer.
Journal of Clinical Oncology, 2013 194 Background: S100A10 is a member of the S100 family of proteins containing two EF-hand calcium-binding motifs. They regulate a number of cellular processes such as cell cycle progression and differentiation. The objective of this study is to clarify
Takuo Watanabe +18 more
core +2 more sources
Regulation of S100A10 by the PML-RAR-α oncoprotein
Blood, 2011 Acute promyelocytic leukemia (APL) is a distinct subtype of acute myeloid leukemia that results from the expression of the promyelocytic leukemia–retinoic acid receptor α (PML-RAR-α) oncoprotein.
Patricia A. Madureira +4 more
core +3 more sources
The ANXA2/S100A10 Complex—Regulation of the Oncogenic Plasminogen Receptor [PDF]
Biomolecules, 2021 The generation of the serine protease plasmin is initiated by the binding of its zymogenic precursor, plasminogen, to cell surface receptors.
David M. Waisman +2 more
core +4 more sources
Involvement of Membranous S100A10 Expression in the Tumor Budding of Colorectal Cancer: An Immunohistochemical Study. [PDF]
J Gastrointest CancerArai K +6 more
europepmc +2 more sources
Identification of an AHNAK binding motif specific for the Annexin2/S100A10 tetramer. [PDF]
Journal of Biological Chemistry, 2006 International audienceThe Annexin2 tetramer (A2t), which consists of two Annexin2 molecules bound to a S100A10 dimer, is implicated in membrane-trafficking events.
Benaud, Christelle +6 more
core +5 more sources