Results 41 to 50 of about 243,891 (236)

Ginsenoside compound K inhibits nuclear factor-kappa B by targeting Annexin A2

Journal of Ginseng Research, 2019
Background: Ginsenoside compound K(C-K), a major metabolite of ginsenoside, exhibits anticancer activity in various cancer cells and animal models.
Yu-Shi Wang, Hongyan Zhu, He Li, Yang Li, Bing Zhao, Ying-Hua Jin   +5 more
doaj   +2 more sources

Revealing Annexin A2 and ARF-6 enrollment during Trypanosoma cruzi extracellular amastigote-host cell interaction

Parasites & Vectors, 2015
Background Invasion of host cells by Trypanosoma cruzi extracellular amastigotes is host actin polymerization-dependent. However, the role of proteins related to actin dynamics during invasion by amastigotes remains to be investigated.
Thaise Lara Teixeira, Lilian Cruz, Renato Arruda Mortara, Claudio Vieira Da Silva   +3 more
doaj   +2 more sources

Annexin A2 antibodies in post-treatment Lyme disease. [PDF]

Ther Adv Infect Dis
Background: Anti-annexin A2 (AA2) antibodies have been described in Lyme arthritis and erythema migrans, although they have not been described in post-treatment Lyme disease (PTLD).
Miller JB, Rebman AW, de Flores MDV, Wang H, Darrah E, Aucott JN.   +5 more
europepmc   +2 more sources

ANXA2 is a potential biomarker for cancer prognosis and immune infiltration: A systematic pan-cancer analysis

Frontiers in Genetics, 2023
Background: Annexin A2 (ANXA2) belongs to the Annexin A family and plays a role in epithelial-mesenchymal transition, fibrinolysis, and other physiological processes. Annexin A2 has been extensively implicated in tumorigenesis and development in previous
Yijie Ning, Yufei Li, Hongqin Wang
doaj   +1 more source

Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor – AKT/ERK pathways [PDF]

Neuroscience Letters, 2021
Abstract Promoting angiogenesis to restore circulation to the ischemic tissue is still an important therapeutic target in stroke. Here, we ask whether the Ca2+-regulated, phospholipid-and membrane-binding protein-Annexin A2 (ANXA2) may regulate angiogenesis after stroke.Compared with wild type (WT) mice, the density of microvessels in brain and
Wenlu Li, Haoran Lin, Zexu Shen, Yun Bei, Taofeng Wei, Zhanyang Yu, Yunjian Dai, Haibin Dai   +7 more
openaire   +2 more sources

Annexin A2: The diversity of pathological effects in tumorigenesis and immune response

International Journal of Cancer, 2022
Annexin A2 (ANXA2) is widely used as a marker in a variety of tumors. By regulating multiple signal pathways, ANXA2 promotes the epithelial‐mesenchymal transition, which can cause tumorigenesis and accelerate thymus degeneration.
Yanjie Huang, Mengzhen Jia, Xiaoqing Yang, Hongyan Han, Gailing Hou, Liangliang Bi, Yueli Yang, Ruoqi Zhang, Xueru Zhao, Chaoqun Peng, Xinshou Ouyang   +10 more
semanticscholar   +1 more source

The annexin A2 system and vascular homeostasis [PDF]

Vascular Pharmacology, 2011
Optimal fibrin balance requires precisely controlled plasmin generation on the surface of endothelial cells, which line the blood vessel wall. As a co-receptor for plasminogen and tissue plasminogen activator (tPA), which are key factors in plasmin generation, the annexin A2 (A2) complex promotes vascular fibrinolysis. The intracellular A2 complex is a
Elle C, Flood, Katherine A, Hajjar
openaire   +2 more sources

Proline/serine‐rich coiled‐coil protein 1 inhibits macrophage inflammation and delays atherosclerotic progression by binding to Annexin A2

Clinical and Translational Medicine, 2023
Background Atherosclerosis (AS), the main pathological basis of life‐threatening cardiovascular disease, is essentially caused by chronic macrophage inflammation.
Hangyu Pan, Zhongzhou Guo, Ping Lv, Kexin Hu, Tongwei Wu, Zixiang Lin, Yazhi Xue, Yanan Zhang, Zhigang Guo   +8 more
semanticscholar   +1 more source

LppA is a novel plasminogen receptor of Mycoplasma bovis that contributes to adhesion by binding the host extracellular matrix and Annexin A2

Veterinary Research, 2023
Mycoplasma bovis is responsible for various inflammatory diseases in cattle. The prevention and control of M. bovis are complicated by the absence of effective vaccines and the emergence of multidrug-resistant strains, resulting in substantial economic ...
Shuang Liu, Zhangcheng Li, Shimei Lan, Huafang Hao, Xiangrui Jin, Jinjia Liang, Ahmed Adel Baz, Xinmin Yan, Pengcheng Gao, Shengli Chen, Yuefeng Chu   +10 more
semanticscholar   +1 more source

Bridging of membrane surfaces by annexin A2 [PDF]

Scientific Reports, 2018
AbstractThe protein-mediated formation of membrane contacts is a crucial event in many cellular processes ranging from the establishment of organelle contacts to the docking of vesicles to a target membrane. Annexins are Ca2+ regulated membrane-binding proteins implicated in providing such membrane contacts; however, the molecular basis of membrane ...
David Grill, Anna L. L. Matos, Wilke C. de Vries, Sergej Kudruk, Milena Heflik, Wolfgang Dörner, Henning D. Mootz, Bart Jan Ravoo, Hans-Joachim Galla, Volker Gerke   +9 more
openaire   +2 more sources