Results 61 to 70 of about 243,891 (236)

Annexin A2 contributes to cisplatin resistance by activation of JNK-p53 pathway in non-small cell lung cancer cells

Journal of Experimental & Clinical Cancer Research, 2017
Background Development of resistance to therapy continues to be a serious clinical problem in lung cancer management. We previously identified that Annexin A2 is significantly up-regulated in cisplatin-resistant non-small cell lung cancer (NSCLC) A549 ...
Xiaomin Feng, Hao Liu, Zhijie Zhang, Yixue Gu, Huisi Qiu, Zhimin He   +5 more
doaj   +1 more source

Low expression of lncRNA-GAS5 is implicated in human primary varicose great saphenous veins. [PDF]

PLoS ONE, 2015
The cellular mechanisms of primary varicose great saphenous veins (GSVs) involve inflammation, apoptosis, and proliferation of local cells and extracellular matrix degradation.
Li Li, Xiang Li, Erlinda The, Li-Jie Wang, Tian-You Yuan, Shi-Yi Wang, Jing Feng, Jing Wang, Yuan Liu, Ya-Han Wu, Xiu-E Ma, Jin Ge, Ying-Yu Cui, Xiao-Yan Jiang   +13 more
doaj   +1 more source

Annexin A2 Regulates TRPA1-Dependent Nociception [PDF]

The Journal of Neuroscience, 2014
The transient receptor potential A1 (TRPA1) channel is essential for vertebrate pain. Even though TRPA1 activation by ligands has been studied extensively, the molecular machinery regulating TRPA1 is only poorly understood. Using an unbiased proteomics-based approach we uncovered the physical association of Annexin A2 (AnxA2) with native TRPA1 in mouse
Luca Avenali, Pratibha Narayanan, Tom Rouwette, Ilaria Cervellini, Michael Sereda, David Gomez-Varela, Manuela Schmidt   +6 more
openaire   +5 more sources

Ekspresi Annexin A2 pada Kanker Ginekologi

Obgynia, 2021
Objective: To determine the relationship between ANXA2 expression and various aspects of gynecological cancer. Method: A structured search for studies involving the relationship of ANXA2 and cervical cancer, endometrial cancer and ovarian cancer using ...
William Alexander Setiawan
doaj   +1 more source

Autoimmunity to annexin A2 predicts mortality among hospitalised COVID-19 patients

European Respiratory Journal, 2021
The pathophysiology of severe coronavirus disease 2019 (COVID-19) has largely been attributed to a hyper-inflammatory response without a clear indication of the underlying mechanism [1].
Marisol Zuniga, C. Gomes, S. Carsons, M. Bender, P. Cotzia, Q. Miao, David C. Lee, A. Rodríguez   +7 more
semanticscholar   +1 more source

Annexin A2 interferes with complement regulation within the glomerulus. [PDF]

J Biol Chem
The alternative pathway of complement is an important pathogenic driver of a variety of glomerular diseases. Factor H is a soluble complement regulatory protein, and it is known to play a critical role in protecting the kidney from alternative pathway-mediated injury.
Renner B, Laskowski J, Poppelaars F, Whelan R, Milliron K, Petr V, Blaine J, Ozekin Y, Ferreira VP, Pickering MC, Schmidt CQ, Hajjar K, Davidson A, Thurman JM.   +13 more
europepmc   +3 more sources

The important roles and molecular mechanisms of annexin A2 autoantibody in children with nephrotic syndrome

Annals of Translational Medicine, 2021
Background In recent years, B-cell dysfunction has been found to play an important role in the pathogenesis of primary nephrotic syndrome (PNS). B cells play a pathogenic role by secreting antibodies against their target antigens after transforming into ...
Qing Ye, Yingying Zhang, Jie-qiu Zhuang, Y. Bi, Hong Xu, Q. Shen, Jialu Liu, Haidong Fu, Jingjing Wang, Chunyue Feng, Xiaoxiao Tang, Fei Liu, W. Gu, Fei Zhao, Jianjiang Zhang, Yuanhan Qin, Shiqiang Shang, Hongqiang Shen, Xuejun Chen, Hui-jun Shen, Ai’min Liu, Yong-hui Xia, Zhihong Lu, Q. Shu, Jianhua Mao   +24 more
semanticscholar   +1 more source

Annexin A2-Mediated Plasminogen Activation in Endothelial Cells Contributes to the Proangiogenic Effect of Adenosine A2A Receptors

Frontiers in Pharmacology, 2021
Adenosine A2A receptor mediates the promotion of wound healing and revascularization of injured tissue, in healthy and animals with impaired wound healing, through a mechanism depending upon tissue plasminogen activator (tPA), a component of the ...
María D. Valls, María Soldado, Jorge Arasa, Jorge Arasa, Miguel Perez-Aso, Adrienne J. Williams, Bruce N. Cronstein, Bruce N. Cronstein, Bruce N. Cronstein, M. Antonia Noguera, M. Antonia Noguera, M. Carmen Terencio, M. Carmen Terencio, M. Carmen Montesinos, M. Carmen Montesinos   +14 more
doaj   +1 more source

Combination of Small Extracellular Vesicle-Derived Annexin A2 Protein and mRNA as a Potential Predictive Biomarker for Chemotherapy Responsiveness in Aggressive Triple-Negative Breast Cancer

Cancers, 2022
Simple Summary Triple-negative breast cancer (TNBC) is a highly aggressive disease. It is marked by a lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2).
Priyanka P. Desai, Kalyani Narra, Johanna D. James, H. Jones, A. Tripathi, J. Vishwanatha   +5 more
semanticscholar   +1 more source

Annexin A2 is required for the early steps of cytokinesis [PDF]

EMBO reports, 2015
Cytokinesis requires the formation of an actomyosin contractile ring between the two sets of sister chromatids. Annexin A2 is a calcium- and phospholipid-binding protein implicated in cortical actin remodeling. We report that annexin A2 accumulates at the equatorial cortex at the onset of cytokinesis and depletion of annexin A2 results in cytokinetic ...
Benaud, Christelle, Le Dez, Gaëlle, Mironov, Sevtlana, Galli, Federico, Reboutier, David, Prigent, Claude   +5 more
openaire   +2 more sources