Results 71 to 80 of about 243,891 (236)

Annexin A2 Is a Novel RNA-binding Protein [PDF]

Journal of Biological Chemistry, 2004
Annexin A2 (ANXA2) is a Ca(2+)-binding protein that is up-regulated in virally transformed cell lines and in human tumors. Here, we show that ANXA2 binds directly to both ribonucleotide homopolymers and human c-myc RNA. ANXA2 was shown to bind specifically to poly(G) with high affinity (K(d) = 60 nM) and not to poly(A), poly(C), or poly(U). The binding
Nolan R, Filipenko, Travis J, MacLeod, Chang-Soon, Yoon, David M, Waisman   +3 more
openaire   +2 more sources

The Annexin A2-Notch regulatory loop in hepatocytes promotes liver fibrosis in NAFLD by increasing osteopontin expression.

Biochimica et Biophysica Acta - Molecular Basis of Disease, 2022
BACKGROUND The mechanisms underlying the progression of liver disease from simple hepatic steatosis to advanced nonalcoholic steatohepatitis (NASH) and liver fibrosis warrant further investigation. Increased mRNA levels of Annexin A2 protein (Anxa2) have
Guangyan Wang, Jinjie Duan, Guangyin Pu, Chenji Ye, Yue Li, Wenjing Xiu, Jingwen Xu, Ben Liu, Yi Zhu, Chunjiong Wang   +9 more
semanticscholar   +1 more source

Annexin A2 plays a key role in protecting against cisplatin-induced AKI through β-catenin/TFEB pathway

Cell Death Discovery, 2022
Acute kidney injury (AKI) is in high prevalence in the world. However, the therapeutic strategies for AKI are still in mystery. Studies have shown to improve autophagy and lysosomal function could inhibit AKI.
Kunyu Shen, Jin-hua Miao, Qiongdan Gao, Xian Ling, Ye Liang, Qingyou Zhou, Qirong Song, Yuxin Luo, Qinyu Wu, Weiwei Shen, Xiaonan Wang, Xiaolong Li, Youhua Liu, Shan Zhou, Ying Tang, Lili Zhou   +15 more
semanticscholar   +1 more source

Cholesterol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembly, and function

, 2011
Cholesterol regulates plasma membrane (PM) association and functioning of syntaxin-4 and soluble N-ethylmaleimide-sensitive fusion protein 23 (SNAP23) in the secretory pathway.
Enrich Bastús, Carles, Tebar Ramon, Francesc, Reverter Martín, Meritxell, Rentero Alfonso, Carles, Meritxell Reverter, Mulay, Vishwaroop, Peta Wood, Vilà de Muga, Sandra, Álvarez-Guaita, Anna, Anna Alvarez-Guaita, Albert Pol, Francesc Tebar, Carlos Enrich, Cairns, Rose, Joan Blasi, Blasi Cabús, Joan, Carles Rentero, Vishwaroop Mulay, Rose Cairns, Wood, Peta, Katia Monastyrskaya, Grewal, Thomas, Pol i Sorolla, Albert, Thomas Grewal, Monastyrskaya, Katia, Sandra Vilà de Muga   +25 more
core   +1 more source

Serum exosomal-annexin A2 is associated with African-American triple-negative breast cancer and promotes angiogenesis

Breast Cancer Research, 2020
Limited information is available on biomarker(s) for triple-negative breast cancer (TNBC) that can address the higher incidence and aggressiveness of TNBC in African-American (AA) women.
P. Chaudhary, L. Gibbs, Sayantan Maji, C. Lewis, Sumihiro Suzuki, J. Vishwanatha   +5 more
semanticscholar   +1 more source

Modulation of Vascular Endothelial Growth Factor and Annexin A2 in Response to 4-(Methylnitrosamino)-1-(3-pyridyl)-1-Butanone -Induced Inflammation via Swimming Training

Iranian Journal of Allergy, Asthma and Immunology, 2018
The nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK; nicotine derived nitrosamine ketone) is one of the strongest carcinogens in tobacco which is involved in induction of lung cancer by changing the stimulation of vascular endothelial ...
Ali Barzegari, Shadmehr Mirdar, Mohammad Ranayi   +2 more
doaj   +1 more source

Selective Targeting of Immune Checkpoints HLA‐G and CD47 Using Novel Dual Signaling Protein DSP216 Promotes Innate Anticancer Immunity

Advanced Science, EarlyView.
The inhibitory immune checkpoints HLA‐G and CD47 are expressed on certain tumor types and inhibit immune cells in the tumor microenvironment. DSP216 binds specifically to cancer cells expressing both HLA‐G and CD47, and blocks their inhibitory signaling.
Lisa J. Jacob, Liat Tamir, Mufeed Abdeen, Ami Tamir, Alexandra Aronin, Itai Bloch, Roy Kahn, Iris Pecker, Mark Tykocinski, Gerwin Huls, Yaron Pereg, Ayelet Chajut, Edwin Bremer   +12 more
wiley   +1 more source

Coupling of Integrin α5 to Annexin A2 by Flow Drives Endothelial Activation

Circulation Research, 2020
Supplemental Digital Content is available in the text. Rationale: Atherosclerosis preferentially occurs at specific sites of the vasculature where endothelial cells (ECs) are exposed to disturbed blood flow.
Chenghu Zhang, Ting Zhou, Zhipeng Chen, Meng Yan, Bochuan Li, Huizhen Lv, Chunjiong Wang, Song Xiang, Lei Shi, Yi Zhu, Ding Ai   +10 more
semanticscholar   +1 more source

Molecular dissection of the membrane aggregation mechanisms induced by monomeric annexin A2

, 2018
Annexins are a multigene family of proteins involved in aggregation and fusion processes of biological membranes. One of its best-known members is annexin A2 (or p36), capable of binding to acidic phospholipids in a calcium-dependent manner, as occurs ...
Turnay Abad, Francisco Javier, Martínez-Carmona, Francisco, Rodríguez Crespo, José Ignacio, Lizarbe Iracheta, María Antonia, López Rodríguez, Juan Carlos   +4 more
core   +1 more source

Angiostrongylus cantonensis Galectin-1 interacts with Annexin A2 to impair the viability of macrophages via activating JNK pathway

Parasites & Vectors, 2020
Background Angiostrongylus cantonensis can cause severe symptoms of central nervous system infections. In the host, this parasite localizes in the blood and cerebrospinal fluid, and its secreted components can impact immune responses.
Xiaomeng Shi, Mengran Xiao, Zhiyue Xie, Qing Shi, Yuanjiao Zhang, Jianmei W. Leavenworth, Baolong Yan, Huicong Huang   +7 more
doaj   +1 more source