Results 81 to 90 of about 243,891 (236)

Endogenous Engineering Reprograms Extracellular Vesicles for Enhanced Therapeutic Function

Advanced Science, EarlyView.
This review explains how Extracellular vesicles‐producing cells can be endogenously engineered to load therapeutic proteins and nucleic acids. We summarize physiological and genetic strategies that harness native sorting pathways for selective cargo loading.
Jinghui Wang, Wenxuan Zhao, Xiaoming Hu, Yishu Wang, Peidong Yang, Diwei Zheng, Yugang Wang, Guanghui Ma, Min Shi, Wei Wei, Shuang Wang   +10 more
wiley   +1 more source

TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy

Cell Death and Disease, 2021
Osteosarcoma (OS) is the most common primary malignant bone tumor in children and adolescents, which is characterized by dysfunctional autophagy and poor differentiation.
Huan-Tian Zhang, Q. Zeng, Baomeng Wu, Junlei Lu, Kui-Leung Tong, Jiebin Lin, Qiuyu Liu, Lipei Xu, Jie Yang, Xiaohui Liu, Wanting Liu, Yunfang Zhang, Qionghua Lian, Langxia Liu, Xuejuan Gao   +14 more
semanticscholar   +1 more source

Cochlin induced TREK-1 co-expression and annexin A2 secretion: role in trabecular meshwork cell elongation and motility. [PDF]

PLoS ONE, 2011
Fluid flow through large interstitial spaces is sensed at the cellular level, and mechanistic responses to flow changes enables expansion or contraction of the cells modulating the surrounding area and brings about changes in fluid flow.
Manik Goel, Adam E Sienkiewicz, Renata Picciani, Richard K Lee, Sanjoy K Bhattacharya   +4 more
doaj   +1 more source

NET‐DNA Activates the ANXA2/TMEM215/BiP Axis to Promote Mitophagy‐Mediated Anoikis Resistance in Endometriosis

Advanced Science, EarlyView.
NET‐DNA is enriched during early endometriotic lesion establishment and drives anoikis resistance by promoting an ANXA2–TMEM215–BiP axis. This pathway strengthens ER–mitochondria contacts, enhances PINK1/Parkin‐associated mitophagy, preserves mitochondrial homeostasis, and supports ectopic stromal cell survival, thereby facilitating lesion persistence ...
Honglin Wang, Yanling Gou, Huiyan Zhang, Hongli Wang, Beidi Wang, Jinming Liu, Yingying Cao, Ruru Bai, Yuxin Zhao, Xu Han, Chao Feng, Xin Huang, Zongfeng Zhang   +12 more
wiley   +1 more source

Annexin A2/TLR2/MYD88 pathway induces arginase 1 expression in tumor-associated neutrophils

Journal of Clinical Investigation, 2022
Myeloid lineage cells suppress T cell viability through arginine depletion via arginase 1 (ARG1). Despite numerous studies exploring the mechanisms by which ARG1 perturbs lymphocyte function, the cellular populations responsible for its generation and ...
Huajia Zhang, Xiaodong Zhu, Travis J Friesen, Jeff W. Kwak, Tatyana Pisarenko, Surapat Mekvanich, Mark A. Velasco, T. Randolph, J. Kargl, A. M. Houghton   +9 more
semanticscholar   +1 more source

Annexin A2 is a soluble mediator of macrophage activation [PDF]

Journal of Leukocyte Biology, 2007
Abstract On the surface of the macrophage, annexin A2 tetramer (A2t) serves as a docking protein or recognition element for bacterial and viral pathogens. Plasma levels of free A2t have been reported to increase following infection, although the mechanistic significance of this observation is unclear. Although annexin A2 had generally
Jennifer F A, Swisher, Utsha, Khatri, Gerald M, Feldman   +2 more
openaire   +2 more sources

Supramolecular Assembly of Stepped‐Persistent ROS Nanogenerator for Sustained Tumor Immunotherapy

Advanced Science, EarlyView.
ROS catalytic systems often fail to achieve both effective tumor elimination and persistent immune activation due to their monotonous ROS production profiles. A stepped‐persistent ROS nanogenerator was developed by supramolecularly assembling multiple ROS generation modules within a nanofiber structure to simultaneously extend ROS generation duration ...
Zhenqiang Wang, Ming Qin, Wenjing Lai, Shiwen Chen, Fengling Wang, Dandan Xie, Maohua Chen, Changpeng Hu, Kui Wang, Rong Zhang, Guobing Li   +10 more
wiley   +1 more source

Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo.

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie, 2020
Chlorogenic acid, an important active component of coffee with anti-tumor activities, has been found for a hundred years. However, the lack of understanding about its target proteins greatly limits the exploration of its anti-tumor molecular mechanisms ...
Lei Wang, H. Du, Peng R. Chen
semanticscholar   +1 more source

Annexin A2 Improves the Osteogenic Differentiation of Mesenchymal Stem Cells Exposed to High-Glucose Conditions through Lessening the Senescence

International Journal of Molecular Sciences, 2022
Osteoporosis is frequently found in chronic diabetic patients, and it results in an increased risk of bone fractures occurring. The underlying mechanism of osteoporosis in diabetic patients is still largely unknown.
Parin Klabklai, Jitrada Phetfong, Rattanawan Tangporncharoen, Chartchalerm Isarankura-Na-Ayudhya, T. Tawonsawatruk, Aungkura Supokawej   +5 more
semanticscholar   +1 more source

MicroRNA-425-5p modulates osteoporosis by targeting annexin A2

Immunity & Ageing, 2021
Background Studies have shown that the decrease of osteogenic differentiation of bone marrow mesenchymal stem cells (MSC) is an important mechanism of osteoporosis.
Guanghua Chen, Guizhi Huang, Han Lin, Xinyou Wu, Xiaoyan Tan, Zhoutao Chen   +5 more
doaj   +1 more source