Results 91 to 100 of about 243,891 (236)
TDP‐43 Aggregation: The Healthy‐Toxic Balance of the Prion‐Like Domain
Advanced Science, EarlyView.TDP‐43 function relies on a delicate balance between reversible phase‐separated states and irreversible aggregation. Under physiological conditions, TDP‐43 forms dynamic droplets and oligomers that support normal cellular functions. In pathological contexts, this balance shifts toward aberrant aggregation, leading to toxic species.
Luca Zangrando +2 more
wiley +1 more source
BMC Genomics, 2022 Background Renal inflammation plays a crucial role during the progression of Chronic kidney disease (CKD), but there is limited research on hub genes involved in renal inflammation. Here, we aimed to explore the effects of Annexin A2 (ANXA2), a potential
Jing Chen +4 more
semanticscholar +1 more source
Annals of Neurology, EarlyView.Objectives The interleukin (IL)‐1, IL‐6, and C‐reactive protein (CRP) pathway is central to the immune response after intracerebral hemorrhage (ICH). We tested for associations between hematoma and plasma cytokine concentrations and patient outcomes in Minimally Invasive Surgery Plus Rt‐PA for ICH Evacuation Phase III (MISTIE III) participants ...
Adrian R. Parry‐Jones +54 more
wiley +1 more source
Frontiers in Oncology, 2022 Annexin A2 (ANXA2) has been found to be involved in cancer proliferation, metastasis and prognosis; however, its exact role in nasopharyngeal carcinoma (NPC) radioresistance remains unknown. We found that ANXA2 expression was correlated with prognosis in
Huocong He +8 more
semanticscholar +1 more source
Annexin A2: biology and relevance to the antiphospholipid syndrome [PDF]
Lupus, 2008 Antiphospholipid antibodies (aPL), the majority of which are directed against β 2 -glycoprotein I (β 2 GPI), are associated with an increased incidence of venous and arterial thrombosis. The pathogenesis of antiphospholipid/anti-β 2
E, Cockrell, R G, Espinola, K R, McCrae
openaire +2 more sources
RNA-binding is an ancient trait of the Annexin family
Frontiers in Cell and Developmental Biology, 2023 Introduction: The regulation of intracellular functions in mammalian cells involves close coordination of cellular processes. During recent years it has become evident that the sorting, trafficking and distribution of transport vesicles and mRNA granules/
Sudarshan S. Patil +7 more
doaj +1 more source
BMEMat, EarlyView.Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu +13 more
wiley +1 more source
Nucleic Acids Research, 2022 The introduction of phosphorothioate (PS) linkages to the backbone of therapeutic nucleic acids substantially increases their stability and potency. It also affects their interactions with cellular proteins, but the molecular mechanisms that underlie ...
M. Hyjek-Składanowska +8 more
semanticscholar +1 more source
Prognostic significance of annexin A2 and annexin A4 expression in patients with cervical cancer [PDF]
BMC Cancer, 2016 The annexins (ANXs) have diverse roles in tumor development and progression, however, their clinical significance in cervical cancer has not been elucidated. The present study was to investigate the clinical significance of annexin A2 (ANXA2) and annexin A4 (ANXA4) expression in cervical cancer.ANXA2 and ANXA4 immunohistochemical staining were ...
Choi, Chel Hun +6 more
openaire +3 more sources
The effects of lncRNA-GAS5 mediated by Annexin A2.
, 2015 A2 = Annexin A2; Mock = control group, only empty plasmid transfected; NC = Negative control group, only control siRNA transfected; A2 siRNA = Annexin A2 knockdown group transfected with silence siRNA; A2 over = Annexin A2 overexpression group ...
Jin Ge (517956) +13 more
core +1 more source