Results 101 to 110 of about 243,891 (236)

Annexins A2 and A5 are potential early biomarkers of hepatocarcinogenesis

Scientific Reports, 2023
Hepatocellular carcinoma (HCC) is a highly lethal liver cancer with late diagnosis; therefore, the identification of new early biomarkers could help reduce mortality.
Ema Elvira Herrera-López, Dafne Guerrero-Escalera, Isaac Aguirre-Maldonado, Arely López-Hernández, Hilda Montero, María Angélica Gutiérrez‐Nava, Luis del Pozo-Yauner, Jaime Arellanes-Robledo, Javier Camacho, Julio Isael Pérez-Carreón   +9 more
doaj   +1 more source

Proteomic signatures of equine dental tooth tissues in ageing and disease

Equine Veterinary Journal, EarlyView.
Abstract Background Ageing and dental disease in horses lead to structural and functional deterioration of dental tissues, yet their molecular signatures remain poorly characterised. Understanding how these processes alter the protein composition of enamel, dentin, cementum and pulp is essential for improving equine oral health and identifying ...
Anders Jensen, Danae Emilie Zambouli, Iris Gringel, Zoe Nugent, Kazuhiro Yamamoto, Lee Cooper, Andrew J. Peffers, Guido Rocchigiani, Mandy J. Peffers   +8 more
wiley   +1 more source

Advances in cancer treatment: a new therapeutic target, Annexin A2

Journal of Cancer, 2021
Annexin A2 (ANXA2) is a calcium regulated phospholipid-binding protein. It is expressed in some tumor cells, endothelial cells, macrophages, and mononuclear cells, affecting cell survival and mediating interactions between intercellular and extracellular
Zinan Li, Lifeng Yu, Baohui Hu, Lianze Chen, Ming-Liang Jv, Lin Wang, Chenyi Zhou, Minjie Wei, Lin Zhao   +8 more
semanticscholar   +1 more source

Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy.

, 2015
Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition,
Moreau, Kevin, Ghislat, Ghita, Puri, Claudia, Runwal, Gautam, Hochfeld, Warren, Ravikumar, Brinda, Lee, Shirley, Zavodszky, Eszter, Menzies, Fiona M., Siddiqi, Farah, Rubinsztein, David C., Renna, Maurizio   +11 more
core   +1 more source

Cordycepin mediates neuroprotection against apoptosis via ERK/CREB signaling activation in Aβ1–42‐induced neuronal cell models

Ibrain, Volume 11, Issue 1, Page 84-97, Spring 2025.
This study demonstrates cordycepin's neuroprotective effects against Aβ1–42‐induced apoptosis in neuronal cells, mediated through the activation of the extracellular signal‐regulated kinase/cyclic AMP‐responsive element‐binding protein (ERK/CREB) signaling pathway.
Wenshu Zhou, Cheng Wang, Yige Tan, Philip Lazarovici, Xiaoyan Wen, Shaoping Li, Wenhua Zheng   +6 more
wiley   +1 more source

Autoimmunity to the Lung Protective Phospholipid-Binding Protein Annexin A2 Predicts Mortality Among Hospitalized COVID-19 Patients

medRxiv, 2021
Background: Annexin A2 is a phospholipid-binding protein involved in fibrinolysis, cell membrane stabilization and repair, and ensuring the integrity of the pulmonary microvasculature.
M. Zuniga, C. Gomes, S. Carsons, M. Bender, P. Cotzia, Q. Miao, D. Lee, A. Rodriguez   +7 more
semanticscholar   +1 more source

Fat Mass and Obesity‐Associated Protein Contributes to Tumorigenesis and Drug Resistance of Diffuse Large B‐Cell Lymphoma by Suppressing N6‐Methyladenosine Methylation of Myc

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ibrutinib resistance remains a major obstacle in the treatment of diffuse large B‐cell lymphoma (DLBCL). Fat mass and obesity‐associated protein (FTO) has been implicated in drug resistance through its regulation of N6‐methyladenosine (m6A) modifications; however, whether FTO mediates ibrutinib resistance in DLBCL remains unclear.
Ting‐Ting Lu, Jin‐Hao Chen, Yan‐Fang Wang, Xiao Wu, Hui‐Yun Ni, Qiu‐Rong Zhang   +5 more
wiley   +1 more source

Bufalin induces mitochondrial dysfunction and promotes apoptosis of glioma cells by regulating Annexin A2 and DRP1 protein expression

Cancer Cell International, 2021
Background Glioma is a common primary central nervous system tumour, and therapeutic drugs that can effectively improve the survival rate of patients in the clinic are lacking.
Yao Li, Yan Zhang, Xu-fang Wang, Qian Yang, Xuanxuan Zhou, Junsheng Wu, Xu Yang, Yani Zhao, Rui Lin, Yanhua Xie, Jiani Yuan, Xiaohui Zheng, Siwang Wang   +12 more
semanticscholar   +1 more source

Annexin A2 is regulated by ovarian cancer-peritoneal cell interactions and promotes metastasis [PDF]

, 2013
Our recent research identified the protein annexin A2 to be regulated by ovarian cancer-peritoneal cell interactions. This study investigated the role of annexin A2 in ovarian cancer metastasis and its potential utility as a novel therapeutic target ...
Lokman, N., Pyragius, C., Oehler, M., Hoffmann, P., Ween, M., Elder, A., Ricciardelli, C.   +6 more
core   +1 more source

Increased resistance of annexin A2-depleted cells to G strain MT invasion.

, 2022
(A) HeLa cells were submitted to lentiviral transduction for annexin A2 knockdown (kd) and analyzed by western blotting. Note the depletion of annexin A2 in two independent cell lines. (B) HeLa cells depleted in annexin A2 and WT cells were incubated for
João Paulo Ferreira Rodrigues (6880928), Silene Macedo (130531), Thiago Souza Onofre (6880925), Leonardo Loch (11579137), Nobuko Yoshida (79221)   +4 more
core   +1 more source