Results 31 to 40 of about 243,891 (236)

Annexin A2: The Importance of Being Redox Sensitive [PDF]

International Journal of Molecular Sciences, 2013
Hydrogen peroxide (H2O2) is an important second messenger in cellular signal transduction. H2O2-dependent signalling regulates many cellular processes, such as proliferation, differentiation, migration and apoptosis. Nevertheless, H2O2 is an oxidant and a major contributor to DNA damage, protein oxidation and lipid peroxidation, which can ultimately ...
Madureira, Patricia, Waisman, David M.
openaire   +5 more sources

Annexin A1 and A2: roles in retrograde trafficking of Shiga toxin. [PDF]

PLoS ONE, 2012
Annexins constitute a family of calcium and membrane binding proteins. As annexin A1 and A2 have previously been linked to various membrane trafficking events, we initiated this study to investigate the role of these annexins in the uptake and ...
Lionel Tcatchoff, Sofia Andersson, Audrun Utskarpen, Tove Irene Klokk, Sigrid S Skånland, Sascha Pust, Volker Gerke, Kirsten Sandvig   +7 more
doaj   +2 more sources

Plasma and Peritoneal Fluid Annexin A2 Levels in Patients with Endometriosis. [PDF]

J Inflamm Res, 2023
Michal Zygarowicz,1,* Joanna Kacperczyk-Bartnik,2,3,* Janusz Sierdzinski,4 Cezary Wojtyla,5,6 Piotr Pierzynski,5,6 Grzegorz Manka,7 Mariusz Kiecka,7 Robert Z Spaczynski,8 Piotr Piekarski,9 Beata Banaszewska,10 Artur Jakimiuk,11,12 Tadeusz Issat ...
Zygarowicz M, Kacperczyk-Bartnik J, Sierdzinski J, Wojtyla C, Pierzynski P, Manka G, Kiecka M, Spaczynski RZ, Piekarski P, Banaszewska B, Jakimiuk A, Issat T, Rokita W, Mlodawski J, Szubert M, Sieroszewski P, Raba G, Szczupak K, Kluz T, Kluza M, Lipa M, Warzecha D, Wielgos M, Koc-Zorawska E, Zorawski M, Laudanski P.   +25 more
europepmc   +2 more sources

A study of annexin A2 and implantation

, 2015
Implantation is a critical step in reproduction. It is complicated and well-coordinated consisting of apposition, attachment and invasion of embryo into the endometrium. The mechanism of implantation is unclear. Our previous proteomic study showed an increase of annexin A2 in the endometrium during the implantation window of mice, consistent with the ...
Wang, Bing, 王冰
openaire   +3 more sources

Identification of natural compounds targeting Annexin A2 with an anti-cancer effect

Protein & Cell, 2018
Annexin A2, a multifunctional tumor associated protein, promotes nuclear factor-kappa B (NF-κB) activation by interacting with NF-κB p50 subunit and facilitating its nuclear translocation. Here we demonstrated that two ginsenosides Rg5 (G-Rg5) and Rk1 (G-
Yu-Shi Wang, He Li, Yang Li, Hongyan Zhu, Ying-Hua Jin   +4 more
doaj   +2 more sources

Membrane Binding Promotes Annexin A2 Oligomerization [PDF]

Cells, 2020
Annexin A2 (AnxA2) is a cytosolic Ca2+ regulated membrane binding protein that can induce lipid domain formation and plays a role in exocytosis and endocytosis.
Anna Lívia Linard Matos, Sergej Kudruk, Johanna Moratz, Milena Heflik, David Grill, Bart Jan Ravoo, Volker Gerke   +6 more
doaj   +3 more sources

The Role of Annexin A2 in Tumorigenesis and Cancer Progression [PDF]

Cancer Microenvironment, 2011
Annexin A2 is a calcium-dependent, phospholipid-binding protein found on various cell types. It is up-regulated in various tumor types and plays multiple roles in regulating cellular functions, including angiogenesis, proliferation, apoptosis, cell migration, invasion and adhesion.
Lokman, N., Ween, M., Oehler, M., Ricciardelli, C.   +3 more
openaire   +4 more sources

Annexin A2 antibodies but not inhibitors of the annexin A2 heterotetramer impair productive HIV-1 infection of macrophages in vitro [PDF]

Virology Journal, 2016
During sexual transmission of human immunodeficiency virus (HIV), macrophages are initial targets for HIV infection. Secretory leukocyte protease inhibitor (SLPI) has been shown to protect against HIV infection of macrophages through interactions with annexin A2 (A2), which is found on the macrophage cell surface as a heterotetramer (A2t) consisting of
Woodham, Andrew W., Sanna, Adriana M., Taylor, Julia R., Skeate, Joseph G., Da Silva, Diane M., Dekker, Lodewijk V., Kast, W. Martin   +6 more
openaire   +4 more sources

Lysyl oxidase-like 4 exerts an atypical role in breast cancer progression that is dependent on the enzymatic activity that targets the cell-surface annexin A2

Frontiers in Oncology, 2023
BackgroundLOX family members are reported to play pivotal roles in cancer. Unlike their enzymatic activities in collagen cross-linking, their precise cancer functions are unclear.
Ni Luh Gede Yoni Komalasari, Ni Luh Gede Yoni Komalasari, Nahoko Tomonobu, Rie Kinoshita, Youyi Chen, Yoshihiko Sakaguchi, Yuma Gohara, Fan Jiang, Ken-ich Yamamoto, Hitoshi Murata, I Made Winarsa Ruma, I Wayan Sumardika, Jin Zhou, Akira Yamauchi, Futoshi Kuribayashi, Yusuke Inoue, Shinichi Toyooka, Masakiyo Sakaguchi   +17 more
doaj   +2 more sources

Annexin A2 negatively regulates IFN-β production through targeting the RLR signaling pathway. [PDF]

J Virol
Annexin A2 (ANXA2) is known to promote the replication of diverse RNA viruses, often through interactions with specific viral proteins. However, whether it also employs a broad-spectrum, virus-independent strategy to facilitate viral replication remains ...
Liu H, Xue M, Feng C, Yu J, Ye G, Zhang K, Huang L, Weng C.   +7 more
europepmc   +2 more sources