Genotoxic agents promote the nuclear accumulation of annexin A2: role of annexin A2 in mitigating DNA damage. [PDF]
PLoS ONE, 2012 Annexin A2 is an abundant cellular protein that is mainly localized in the cytoplasm and plasma membrane, however a small population has been found in the nucleus, suggesting a nuclear function for the protein.
Patricia A Madureira +3 more
doaj +8 more sources
Annexin A2 in Inflammation and Host Defense [PDF]
Cells, 2020 Annexin A2 (AnxA2) is a multifunctional calcium2+ (Ca2+) and phospholipid-binding protein that is expressed in a wide spectrum of cells, including those participating in the inflammatory response.
Valentina Dallacasagrande +1 more
doaj +4 more sources
Annexin A2 in Fibrinolysis, Inflammation and Fibrosis [PDF]
International Journal of Molecular Sciences, 2021 As a cell surface tissue plasminogen activator (tPA)-plasminogen receptor, the annexin A2 (A2) complex facilitates plasmin generation on the endothelial cell surface, and is an established regulator of hemostasis.
Hana I Lim, K. Hajjar
semanticscholar +4 more sources
PLoS ONE, 2007 BackgroundAnnexin A2 is a peripheral membrane protein that belongs to the annexin family of Ca(2+) and phospholipid-binding proteins. This protein, which plays a role in membrane organization and dynamics in particular along the endocytic pathway, exists
Etienne Morel, Jean Gruenberg
doaj +6 more sources
The flavagline FL3 interferes with the association of Annexin A2 with the eIF4F initiation complex and transiently stimulates the translation of annexin A2 mRNA. [PDF]
Front Cell Dev Biol, 2023 Introduction: Annexin A2 (AnxA2) plays a critical role in cell transformation, immune response, and resistance to cancer therapy. Besides functioning as a calcium- and lipidbinding protein, AnxA2 also acts as an mRNA-binding protein, for instance, by ...
Grindheim AK +4 more
europepmc +9 more sources
Inhibition of the membrane repair protein annexin-A2 prevents tumor invasion and metastasis. [PDF]
Cell Mol Life Sci, 2023 Cancer cells are exposed to major compressive and shearing forces during invasion and metastasis, leading to extensive plasma membrane damage. To survive this mechanical stress, they need to repair membrane injury efficiently.
Gounou C +21 more
europepmc +2 more sources
Annexin A2 and cancer: A systematic review
International Journal of Oncology, 2017 Annexin A2 is a 36-kDa protein interfering with multiple cellular processes especially in cancer progression. The present review aimed to show the relations between Annexin A2 and cancer. A systematic search for studies investigating cancer and Annexin A2 expression was conducted using PubMed.
Maria Christensen +3 more
openaire +5 more sources
The intricate role of annexin A2 in kidney: a comprehensive review. [PDF]
Ren Fail, 2023 Annexin A2 (Anxa2) is a calcium (Ca2+)-regulated phospholipid binding protein composed of a variable N-terminus and a conserved core domain. This protein has been widely found in many tissues and fluids, including tubule cells, glomerular epithelial ...
Lei J +5 more
europepmc +2 more sources
Accumulation of annexin A2 and S100A10 prevents apoptosis of apically delaminated, transformed epithelial cells. [PDF]
Proc Natl Acad Sci U S A, 2023 Significance When epithelial cells detach from the basal substratum and are extruded into the apical lumen, they will be subjected to physical stresses including the increased reactive oxygen species (ROS) and eventually undergo apoptosis.
Ito S +18 more
europepmc +2 more sources
Unlocking tumor barrier: annexin A2-mediated transcytosis boosts drug delivery in pancreatic and breast tumors. [PDF]
Nat CommunThe efficacy of many cancer nanocarriers has traditionally been attributed to enlarged tumor vasculature fenestrations, giving rise to the concept of the enhanced permeability and retention (EPR) effect.
Liu Y +10 more
europepmc +2 more sources