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Annexin-A1 - A Blessing or a Curse in Cancer?
Trends in Molecular Medicine, 2019Annexin-A1 (ANXA1), a potent endogenous immunomodulatory protein has been implicated in multiple functions essential in cancer, including cell proliferation, apoptosis, chemosensitivity, metastasis, and invasion.
S. L. Foo +3 more
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The Crystal Structure of Annexin A8 is Similar to that of Annexin A3
Journal of Molecular Biology, 2005Annexin A8 is a relatively infrequent and poorly studied member of this large family of calcium-binding and membrane-binding proteins. It is, however, associated with a specific disease, acute promyelocytic leukemia. We have solved its three-dimensional structure, which includes a moderately long and intact N terminus.
Réty, Stéphane +9 more
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Science, 1992
The annexins are a group of homologous proteins that bind phospholipids in the presence of calcium. They may provide a major pathway for communication between cellular membranes and their cytoplasmic environment. Annexins have a characteristic "bivalent" activity in the sense that they can draw two membranes together when activated by calcium. This has
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The annexins are a group of homologous proteins that bind phospholipids in the presence of calcium. They may provide a major pathway for communication between cellular membranes and their cytoplasmic environment. Annexins have a characteristic "bivalent" activity in the sense that they can draw two membranes together when activated by calcium. This has
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Annexins in the secretory pathway
Cellular and Molecular Life Sciences (CMLS), 1997Among the multiplicity of roles suggested for proteins of the annexin family, those implicating these proteins in regulated exocytosis remain among the most convincing. Studies in this area of annexin biology have focused on annexin II, which because of its unusually low Ca(2+)-requirement for phospholipid-binding has many of the requisite properties ...
S R, Donnelly, S E, Moss
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Clinica Chimica Acta, 2015
Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis, and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemoresistance of colorectal cancer (CRC), esophageal squamous cell carcinoma ...
Bin, Wei +3 more
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Annexin A4 (Anxa4) is one of the Ca(2+)-regulated and phospholipid-binding annexin superfamily proteins. Anxa4 has a potential role in diagnosis, prognosis, and treatment of certain cancers. Studies indicate that Anxa4 up-regulation promotes the progression of tumor and chemoresistance of colorectal cancer (CRC), esophageal squamous cell carcinoma ...
Bin, Wei +3 more
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Calcium Signaling and Annexins
Cell Biochemistry and Biophysics, 2000The annexins, are a family of calcium ion (Ca2+)-binding proteins whose physiological functions are poorly understood. Although many diverse functions have been proposed for these proteins, such as in vesicle trafficking, this review focuses on their proposed roles as Ca2+ or other ion channels, or as intracellular ion channel regulators.
T E, Hawkins, C J, Merrifield, S E, Moss
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1999
Abstract The sequence organization of the family is highly conserved (Fig. 3). Annexins consist of a conserved core region composed of four repeated domains and a unique N-terminal tail. Annexin VI is unique in that it contains eight domains. Each core contains several calcium- and phospholipid-binding sites.
Marcia A Kaetzel, John R Dedman
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Abstract The sequence organization of the family is highly conserved (Fig. 3). Annexins consist of a conserved core region composed of four repeated domains and a unique N-terminal tail. Annexin VI is unique in that it contains eight domains. Each core contains several calcium- and phospholipid-binding sites.
Marcia A Kaetzel, John R Dedman
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The International Journal of Biochemistry & Cell Biology, 1997
Annexin II belongs to a family of calcium-dependent, phospholipid binding proteins. Annexin II was first identified as an intracellular protein and attributed intracellular functions. Although it lacks a signal peptide and its mechanism of secretion is unknown, extracellular annexin II has recently been found in several tissues as both soluble and ...
D A, Siever, H P, Erickson
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Annexin II belongs to a family of calcium-dependent, phospholipid binding proteins. Annexin II was first identified as an intracellular protein and attributed intracellular functions. Although it lacks a signal peptide and its mechanism of secretion is unknown, extracellular annexin II has recently been found in several tissues as both soluble and ...
D A, Siever, H P, Erickson
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Annexins and Endosomal Signaling
2014Cell signaling and endocytosis are intimately linked in eukaryotic cells. Signaling receptors at the cell surface enter the endocytic pathway and continue to activate downstream effectors in endosomal compartments. This spatiotemporal regulation of signal transduction provides opportunity for signal diversity and a cell-specific machinery of ...
Francesc, Tebar +7 more
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Trends in Cell Biology, 1993
Annexins have long been though to be involved in exocytosis, possibly by helping to create close interactions between membranes destined to undergo fusion. In this article, we examine recent observations that implicate annexins in three different steps of the endocytic pathway, suggesting that annexins may be universal modulators of membrane ...
Gruenberg, Jean, Emans, Neil
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Annexins have long been though to be involved in exocytosis, possibly by helping to create close interactions between membranes destined to undergo fusion. In this article, we examine recent observations that implicate annexins in three different steps of the endocytic pathway, suggesting that annexins may be universal modulators of membrane ...
Gruenberg, Jean, Emans, Neil
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