Results 51 to 60 of about 241,609 (354)
PharmaceuticalsDespite progress in the management of patients with retinal vascular and degenerative diseases, there is still an unmet clinical need for safe and effective therapeutic options with novel mechanisms of action.
Anna Frostegård, Anders Haegerstrand
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Frontiers in Neurology, 2018 Glaucoma is one of the leading causes of irreversible blindness in the world. It is characterized by the progressive loss of retinal ganglion cells (RGCs), mainly through the process of apoptosis.
Elizabeth Yang +8 more
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Trends in Cell Biology, 1997 Ten years after the discovery of annexins, we are just understanding the functions of these enigmatic proteins, been a frustrating decade for those in this field because appear capable of performing a multitude of function: to the sceptic apparently do nothing in vivo.
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Real-Time Imaging of Retinal Ganglion Cell Apoptosis
Cells, 2018 Monitoring real-time apoptosis in-vivo is an unmet need of neurodegeneration science, both in clinical and research settings. For patients, earlier diagnosis before the onset of symptoms provides a window of time in which to instigate treatment.
Timothy E. Yap +3 more
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Annexin A1: Uncovering the Many Talents of an Old Protein
International Journal of Molecular Sciences, 2018 Annexin A1 (ANXA1) has long been classed as an anti-inflammatory protein due to its control over leukocyte-mediated immune responses. However, it is now recognized that ANXA1 has widespread effects beyond the immune system with implications in ...
Madeeha H. Sheikh, E. Solito
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Oncology letters, 2021 Annexin A3 (ANXA3), an annexin family member, contains 36 kDa and 33 kDa isoforms. Similar to other annexin members, ANXA3 plays an important role in the development of human diseases. Recent studies have reported that abnormal ANXA3 expression is closely associated with the development, progression, metastasis, drug resistance and prognosis of several
Liu, Chao +3 more
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Plant Physiology, 1995 Ca2" plays a major role in stimulus-response coupling for many plant cell signaling pathways (Bush, 1995). A variety of stimuli, including light, touch, and orientation changes, can induce a sharp increase in the equilibrium level of free Ca2" in the cytoplasm of plant cells, from a concentration that is usually maintained at below 0.3 gM to often well
G B, Clark, S J, Roux
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Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
Annexin-A1: Therapeutic Potential in Microvascular Disease
Frontiers in Immunology, 2019 Annexin-A1 (ANXA1) was first discovered in the early 1980's as a protein, which mediates (some of the) anti-inflammatory effects of glucocorticoids. Subsequently, the role of ANXA1 in inflammation has been extensively studied.
G. Purvis, E. Solito, C. Thiemermann
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‘Annexins’ themed section [PDF]
British Journal of Pharmacology, 2015 Linked ArticlesThis article is part of a themed section on Annexins VII Programme.
R J, Flower, M, Perretti
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